Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Daniel, Hoffmann"'
Autor:
Simo Kitanovski, Yingying Cao, Dimitris Ttoouli, Farnoush Farahpour, Jun Wang, Daniel Hoffmann
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Visualization approaches transform high-dimensional data from single cell RNA sequencing (scRNA-seq) experiments into two-dimensional plots that are used for analysis of cell relationships, and as a means of reporting biological i
Externí odkaz:
https://doaj.org/article/685ce80f31a5476b80242a1eb9a592da
Autor:
Jun Wang, Qian Li, Yuanwang Qiu, Simo Kitanovski, Chen Wang, Chenxia Zhang, Fahong Li, Xiaoguang Li, Zhenfeng Zhang, Lihua Huang, Jiming Zhang, Daniel Hoffmann, Mengji Lu, Hongzhou Lu
Publikováno v:
iMeta, Vol 3, Iss 4, Pp n/a-n/a (2024)
Abstract Functional cure for chronic hepatitis B (CHB) remains challenging due to the lack of direct intervention methods for hepatic inflammation. Multi‐omics research offers a promising approach to understand hepatic inflammation mechanisms in CH
Externí odkaz:
https://doaj.org/article/7d2ca95ea4884409bfbf98c7c7b7d46b
Autor:
Zehra Karakoese, Vu-Thuy Khanh Le-Trilling, Jonas Schuhenn, Sandra Francois, Mengji Lu, Jia Liu, Mirko Trilling, Daniel Hoffmann, Ulf Dittmer, Kathrin Sutter
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTDuring viral infections, type I interferons (IFN) are induced and play a key role in counteracting initial viral spread. Twelve different human IFNα subtypes exist that bind the same receptor; however, they elicit unique host responses and d
Externí odkaz:
https://doaj.org/article/377a20afbe4547f6abdae03324ad4c6a
Autor:
Arthur T. Porfetye, Patricia Stege, Rocio Rebollido-Rios, Daniel Hoffmann, Thomas Schrader, Ingrid R. Vetter
Publikováno v:
Molecules, Vol 29, Iss 8, p 1764 (2024)
To understand the biological relevance and mode of action of artificial protein ligands, crystal structures with their protein targets are essential. Here, we describe and investigate all known crystal structures that contain a so-called “molecular
Externí odkaz:
https://doaj.org/article/64b2d97b96ff4a429781cd50dd2874b9
Autor:
Fabian Gude, Jurij Froese, Dominique Manikowski, Daniele Di Iorio, Jean-Noël Grad, Seraphine Wegner, Daniel Hoffmann, Melissa Kennedy, Ralf P. Richter, Georg Steffes, Kay Grobe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The Hedgehog morphogen creates gradients during development, but diffusion alone cannot explain its spatiotemporal dynamics. Hedgehog transport requires binding heparan sulfate sugar chains, and the authors now show that Hedgehogs can spread by inter
Externí odkaz:
https://doaj.org/article/716e902b0b7e4784b0dc71931f62a5e0
Autor:
Neda Rafieiolhosseini, Matthias Killa, Thorben Neumann, Niklas Tötsch, Jean-Noël Grad, Alexander Höing, Thies Dirksmeyer, Jochen Niemeyer, Christian Ottmann, Shirley K. Knauer, Michael Giese, Jens Voskuhl, Daniel Hoffmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1322-1331 (2022)
The 14-3-3 protein family, one of the first discovered phosphoserine/phosphothreonine binding proteins, has attracted interest not only because of its important role in the cell regulatory processes but also due to its enormous number of interactions
Externí odkaz:
https://doaj.org/article/d60fc9a2fd0f4a07b702ee811fd82535
Autor:
Battur Magvan, Anne Alina Kloeble, Johannes Ptok, Daniel Hoffmann, Daniel Habermann, Anuujin Gantumur, Martha Paluschinski, Gerelmaa Enebish, Vera Balz, Johannes C. Fischer, Battogtokh Chimeddorj, Andreas Walker, Jörg Timm
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionThe Hepatitis Delta Virus (HDV) is a defective, single-stranded RNA virusoid encoding for a single protein, the Hepatitis Delta Antigen (HDAg), which requires the hepatitis B virus (HBV) envelope protein (HBsAg) for its transmission. Curr
Externí odkaz:
https://doaj.org/article/d8369fd098da4b92ad5f636f417decf5
Autor:
Teresa Bertram, Daniel Hoffmann Ayala, Maria Huber, Felix Brandl, Georg Starke, Christian Sorg, Satja Mulej Bratec
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionThreat processing, enabled by threat circuits, is supported by a remarkably conserved neural architecture across mammals. Threatening stimuli relevant for most species include the threat of being attacked by a predator or an aggressive co
Externí odkaz:
https://doaj.org/article/7871c83ce603451d9dfe3b651aae8126
Autor:
Andreas Walker, Tatjana Schwarz, Janine Brinkmann-Paulukat, Karin Wisskirchen, Christopher Menne, Elahe Salimi Alizei, Helenie Kefalakes, Martin Theissen, Daniel Hoffmann, Julian Schulze zur Wiesch, Mala K. Maini, Markus Cornberg, Anke RM Kraft, Verena Keitel, Hans H. Bock, Peter A. Horn, Robert Thimme, Heiner Wedemeyer, Falko M. Heinemann, Tom Luedde, Christoph Neumann-Haefelin, Ulrike Protzer, Jörg Timm
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background and aimsThere is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on reco
Externí odkaz:
https://doaj.org/article/a835df343e524209b827b09b26d8af46
Autor:
Hendrik Streeck, Alvino Maestri, Daniel Habermann, Trevor A. Crowell, Allahna L. Esber, Gowoon Son, Leigh Anne Eller, Michael A. Eller, Ajay P. Parikh, Peter A. Horn, Lucas Maganga, Emmanuel Bahemana, Yakubu Adamu, Francis Kiweewa, Jonah Maswai, John Owuoth, Merlin L. Robb, Nelson L. Michael, Christina S. Polyak, Daniel Hoffmann, Julie A. Ake
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104182- (2022)
Summary: Background: Immune activation is a significant contributor to HIV pathogenesis and disease progression. In virally-suppressed individuals on ART, low-level immune activation has been linked to several non-infectious comorbid diseases. Howeve
Externí odkaz:
https://doaj.org/article/0e31252779244d96ac9ee4de37fb237b