Interplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19

Autor: Ziad, Bakouny, Chris, Labaki, Punita, Grover, Joy, Awosika, Shuchi, Gulati, Chih-Yuan, Hsu, Saif I, Alimohamed, Babar, Bashir, Stephanie, Berg, Mehmet A, Bilen, Daniel, Bowles, Cecilia, Castellano, Aakash, Desai, Arielle, Elkrief, Omar E, Eton, Leslie A, Fecher, Daniel, Flora, Matthew D, Galsky, Margaret E, Gatti-Mays, Alicia, Gesenhues, Michael J, Glover, Dharmesh, Gopalakrishnan, Shilpa, Gupta, Thorvardur R, Halfdanarson, Brandon, Hayes-Lattin, Mohamed, Hendawi, Emily, Hsu, Clara, Hwang, Roman, Jandarov, Chinmay, Jani, Douglas B, Johnson, Monika, Joshi, Hina, Khan, Shaheer A, Khan, Natalie, Knox, Vadim S, Koshkin, Amit A, Kulkarni, Daniel H, Kwon, Sara, Matar, Rana R, McKay, Sanjay, Mishra, Feras A, Moria, Amanda, Nizam, Nora L, Nock, Taylor K, Nonato, Justin, Panasci, Lauren, Pomerantz, Andrew J, Portuguese, Destie, Provenzano, Matthew, Puc, Yuan J, Rao, Terence D, Rhodes, Gregory J, Riely, Jacob J, Ripp, Andrea V, Rivera, Erika, Ruiz-Garcia, Andrew L, Schmidt, Adam J, Schoenfeld, Gary K, Schwartz, Sumit A, Shah, Justin, Shaya, Suki, Subbiah, Lisa M, Tachiki, Matthew D, Tucker, Melissa, Valdez-Reyes, Lisa B, Weissmann, Michael T, Wotman, Elizabeth M, Wulff-Burchfield, Zhuoer, Xie, Yuanchu James, Yang, Michael A, Thompson, Dimpy P, Shah, Jeremy L, Warner, Yu, Shyr, Toni K, Choueiri, Trisha M, Wise-Draper, Catherine, Stratton

Publikováno v: JAMA oncology.

ImportanceCytokine storm due to COVID-19 can cause high morbidity and mortality and may be more common in patients with cancer treated with immunotherapy (IO) due to immune system activation.ObjectiveTo determine the association of baseline immunosup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065e94f84a466939ff80f5cd04b003ce
https://pubmed.ncbi.nlm.nih.gov/36326731

Abstract CT221: Phase II of frontline maintenance rucaparib in combination with nivolumab in ES SCLC

Autor: Aman Chauhan, Jill Kolesar, Donglin Yan, Zhonglin Hao, Ronald McGarry, John Villano, Ralph Zinner, Ashish Maskey, Jordan Miller, Timothy Mullett, Aman Khurana, Xitong Zhou, Garima Gupta, Daniel Flora, Colleen Darnell, Richard O'Neil, Charles Kunos, Mark B. Evers, Lowell Anthony, Susanne Arnold

Publikováno v: Cancer Research. 83:CT221-CT221

Purpose: Immune checkpoint inhibitor (ICI) maintenance therapy is standard of care for frontline management of extensive stage small cell lung cancer (ES SCLC). However, overall survival benefit of addition of ICI maintenance to frontline ES SCLC tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35b8543b29f48a807c2575a354336de9
https://doi.org/10.1158/1538-7445.am2023-ct221

Oxybutynin vs Placebo for Hot Flashes in Women With or Without Breast Cancer: A Randomized, Double-Blind Clinical Trial (ACCRU SC-1603)

Autor: Eric G. Wolfe, Charles L. Loprinzi, Daniel Flora, Mark L Graham, Roberto A. Leon-Ferre, Stephanie S. Faubion, Kathryn J. Ruddy, Christopher S R Dakhil, Kendrith M. Rowland, Nguyet A. Le-Lindqwister, Paul J. Novotny, Thomas J. Smith

Publikováno v: JNCI Cancer Spectrum

Background Hot flashes (HFs) negatively affect quality of life among perimenopausal and postmenopausal women. This study investigated the efficacy of oxybutynin vs placebo in decreasing HFs. Methods In this randomized, multicenter, double-blind study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58afbbf681dc920bde148a3ab777a896
https://pubmed.ncbi.nlm.nih.gov/32337497