Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Daniel, Farran"'
1
Slight structural modulation around a pivotal bond: high impact on enantiomeric stability
Autor: Giulia Bossa, Marion Jean, Christian Roussel, Daniel Farran, Vincent Belot, Muriel Albalat, Nicolas Vanthuyne
Publikováno v: New Journal of Chemistry
New Journal of Chemistry, 2021, 45 (35), pp.16039-16047. ⟨10.1039/d1nj03178c⟩
International audience; Based on a N-arylthiazoline scaffold, 22 structures with a N-Caryl chiral axis were synthesized exhibiting a huge molecular diversity for the four flanking substituents around the pivotal bond. The determination of their corre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a43dbc8556098d71e31d79e78b9aa3
https://doi.org/10.1039/d1nj03178c
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2
Relayed Proton Brake in N-Pyridyl-2-iso-propylaniline Derivative: Two Brakes with One Proton
Autor: Osamu Kitagawa, Yuki Homma, Gaku Furukawa, Nicolas Vanthuyne, Daniel Farran, Takeshi Shirai, Christian Roussel, Elsa Caytan
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2020, 85 (7), pp.5109-5113. ⟨10.1021/acs.joc.0c00284⟩
Journal of Organic Chemistry, 2020, 85 (7), pp.5109-5113. ⟨10.1021/acs.joc.0c00284⟩
International audience; The addition of methanesulfonic acid to N-(2,6-dimethylpyridin-4-yl)-N-methyl-2-iso-propylaniline led to the selective protonation of the pyridine nitrogen atom, resulting in a significant deceleration of the rotation rates ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b67a0b1498b742ca32d74198f67acc
https://doi.org/10.1021/acs.joc.0c00284
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4
N-C Axially Chiral Compounds with an ortho-Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction
Autor: Christian Roussel, Daniel Farran, Asumi Iida, Mizuki Matsuoka, Nicolas Vanthuyne, Hiroshi Hasegawa, Osamu Kitagawa
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (6), pp.3169-3175. ⟨10.1021/acs.joc.8b03043⟩
Journal of Organic Chemistry, 2019, 84 (6), pp.3169-3175. ⟨10.1021/acs.joc.8b03043⟩
International audience; The fluorine atom is the second smallest atom; nevertheless, the ortho-fluoro group may lead to stable N-aryl atropisomers when the steric demand of the flanking substituents is large enough. 2-Alkyl-3-(2-fluorophenyl)quinazol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4d38e065619ddc35072a9ae2acb5db
https://pubmed.ncbi.nlm.nih.gov/30735620
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5
Atropisomerism in a 10-Membered Ring with Multiple Chirality Axes: (3 Z ,9 Z )-1,2,5,8-Dithiadiazecine-6,7(5 H ,8 H )-dione Series
Autor: Christian Roussel, Dominique Lorcy, Guilhem Javierre, Nicolas Vanthuyne, Patrick Piras, Roberta Fruttero, Marion Jean, Michel Giorgi, Vesna Risso, Daniel Farran, Jean-Valère Naubron
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, 2018, 83 (15), pp.7566-7573. ⟨10.1021/acs.joc.8b01009⟩
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (15), pp.7566-7573. ⟨10.1021/acs.joc.8b01009⟩
International audience; For the first time, chirality in (3 Z,9 Z)-1,2,5,8-dithiadiazecine-6,7(5 H,8 H)-dione series was recognized. Enantiomers of the 4,9-dimethyl-5,8-diphenyl analogue were isolated at room temperature, and their thermal stability
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46c75a1d9591ca36c33341534f4fcf8
https://hal.science/hal-01817538/document
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6
A Forgotten Chiral Spiro Compound Revisited: 3,3'-Dimethyl-3H,3'H-2,2'-spirobi[[1,3]benzothiazole]
Autor: Marion Jean, Daniel Farran, Jean-Valère Naubron, Valérie Monnier, Christian Roussel, Angélique Lindamulage De Silva, Michel Giorgi, Vesna Risso, Nicolas Vanthuyne
Publikováno v: Chirality. 27:716-721
The title compound was obtained as a side product during dimerization-oxidation steps of the carbene generated from N-methylbenzothiazolium iodide. Chromatography on (S,S)-Whelk O1 column showed on cooling a typical plateau shape chromatogram indicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95db9327edc8d1fb00276d18b6a747bd
https://doi.org/10.1002/chir.22492
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7
Steric Scale of Common Substituents from Rotational Barriers of N -( o -Substituted aryl)thiazoline-2-thione Atropisomers
Autor: Nicolas Vanthuyne, Christian Roussel, Vincent Belot, Daniel Farran, Marion Jean, Muriel Albalat
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2017, 82 (19), pp.10188-10200. ⟨10.1021/acs.joc.7b01698⟩
Journal of Organic Chemistry, 2017, 82 (19), pp.10188-10200. ⟨10.1021/acs.joc.7b01698⟩
International audience; A steric scale of 20 recurrent groups was established from comparison of rotational barriers on N-(o-substituted aryl)thiazoline-2-thione atropisomers. The resulting energy of activation ΔG ⧧ rot reflects the spatial requir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9a92d4550ec51ef590631e8b1c55fd
https://hal.archives-ouvertes.fr/hal-01682730/file/2017-farran-et-al.pdf
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8
Fast Pd- and Pd/Cu-Catalyzed Direct C–H Arylation of Cyclic Nitrones. Application to the Synthesis of Enantiopure Quaternary α-Amino Esters
Autor: Emilien Demory, Benoit Baptiste, Pierre Y. Chavant, Véronique Blandin, Daniel Farran
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2012, 77 (18), pp.7901-12. ⟨10.1021/jo301114k⟩
International audience; Cocatalysis by pivalic acid or copper bromide allows a very fast, clean, and high-yielding palladium-catalyzed coupling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO. The study of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae7a5cfdc9131c36c4e2782714bbb54
https://doi.org/10.1021/jo301114k
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9
Regioselective and sequential reactivity of activated 2,5-diketopiperazines
Autor: Georges Dewynter, Jean Martinez, Daniel Farran, Delphine Echalier
Publikováno v: Journal of Peptide Science. 15:474-478
The electrophilic reactivity of Boc-DKPs has been studied. Thanks to Boc activation, the opening ability of carbonyl lactam groups is enhanced. According to experimental conditions, this enabled the synthesis of Boc-amino acid derivatives or original
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d26e94f9d1c5676851b097f4db5c93
https://doi.org/10.1002/psc.1139
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10
[15N]-Isotopic labeling: a suitable tool to study the reactivity of bis lactams
Autor: Jean Martinez, Georges Dewynter, Thibault Coursindel, Daniel Farran
Publikováno v: Tetrahedron Letters. 49:906-909
The unexpected reactivity of 2,5-diketopiperazines under basic conditions, thanks to N -Boc activation, allows access to valuable pharmacological scaffolds, such as original statine derivatives. Toward this transannular rearrangement of activated lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a1e46075b828d02a026d12abd62ffed
https://doi.org/10.1016/j.tetlet.2007.11.159
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