Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniel, Farny"'
Autor:
Henrick Riemenschneider, Francesca Simonetti, Udit Sheth, Eszter Katona, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K. Schmidt, Andrew Flatley, Aloys Schepers, Lara A. Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz, Thomas Arzberger, Jochen Herms, Regina Feederle, Tania F. Gendron, Dorothee Dormann, Dieter Edbauer
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-26 (2023)
Abstract Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar degeneration, but no disease-modi
Externí odkaz:
https://doaj.org/article/d7d0c5c3d184474fbef7b702542a9df6
Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model
Autor:
Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Abstract The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical translation of the expanded repeat results in abundant poly‐GA inclusion pathology t
Externí odkaz:
https://doaj.org/article/94311c357d894315a7a860a7ca6f1ed6
Autor:
Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F. Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Felix Meissner, Rubén Fernández‐Busnadiego, Dieter Edbauer
Publikováno v:
Embo Reports, 23(6):e53890. Wiley
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
International audience; Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f47f8b65554198f2de3cc8266a570e
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
Autor:
Mareike, Czuppa, Ashutosh, Dhingra, Qihui, Zhou, Carina, Schludi, Laura, König, Elisabeth, Scharf, Daniel, Farny, Anupriya, Dalmia, Joachim, Täger, Melissa, Castillo-Lizardo, Eszter, Katona, Kohji, Mori, Tina, Aumer, Florian, Schelter, Markus, Müller, Thomas, Carell, Tuomo, Kalliokoski, Josef, Messinger, Patrizia, Rizzu, Peter, Heutink, Dieter, Edbauer
Publikováno v:
Cell reports. 39(10)
An intronic (G
Autor:
Mareike Czuppa, Ashutosh Dhingra, Qihui Zhou, Carina Schludi, Laura König, Elisabeth Scharf, Daniel Farny, Anupriya Dalmia, Joachim Täger, Melissa Castillo-Lizardo, Eszter Katona, Kohji Mori, Tina Aumer, Florian Schelter, Markus Müller, Thomas Carell, Tuomo Kalliokoski, Josef Messinger, Patrizia Rizzu, Peter Heutink, Dieter Edbauer
Publikováno v:
Cell reports 39(10), 110913 (2022). doi:10.1016/j.celrep.2022.110913
An intronic (G4C2)n expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia primarily through gain-of-function mechanisms: the accumulation of sense and antisense repeat RNA foci and dipeptide repeat (DPR) proteins (poly
Autor:
Frédéric Frottin, Franz-Ulrich Hartl, Rubén Fernández-Busnadiego, Dieter Edbauer, Qiang Guo, Felix Meissner, Wolfgang Baumeister, Mark S. Hipp, H. Riemenschneider, Christian Haass, Matthias Mann, Jakob M. Bader, Daniel Farny, Gernot Kleinberger
TDP-43 inclusions enriched in C-terminal fragments of ~25kDa (“TDP-25”) are associated with neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we analyzed gain-of-function mechanisms of TDP-25 combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050facd517d2b6c32825bcf6a2f6876d
https://doi.org/10.1101/2021.03.15.435268
https://doi.org/10.1101/2021.03.15.435268
Autor:
Mareike Czuppa, Meike Michaelsen, Nikola Mareljic, Hannelore Hartmann, Henrick Riemenschneider, F. Ulrich Hartl, Mark S. Hipp, Frédéric Frottin, Bahram Khosravi, Qihui Zhou, Daniel Farny, Dieter Edbauer, Thomas Arzberger, Kathrine D LaClair
Publikováno v:
The EMBO Journal, 39:e102811. Wiley
EMBO JOURNAL
The EMBO journal 39(8), e102811 (2020). doi:10.15252/embj.2019102811
The EMBO Journal
EMBO JOURNAL
The EMBO journal 39(8), e102811 (2020). doi:10.15252/embj.2019102811
The EMBO Journal
The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72‐specific pathology and TDP‐43 pathology linked to neurodegeneration hinders targeted therapeutic development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43e4f1bd9cfbc715390319e28d66b75
https://research.rug.nl/en/publications/dba56011-e77e-4ed5-8c61-5a2007e2749e
https://research.rug.nl/en/publications/dba56011-e77e-4ed5-8c61-5a2007e2749e
Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model
Autor:
Regina Feederle, Dieter Edbauer, Christian Haass, Qihui Zhou, Stefan Roth, Carina Schludi, Helmut Blum, Meike Michaelsen, Mareike Czuppa, Alexander Graf, Stefan Krebs, Samira Parhizkar, Thomas Arzberger, Arthur Liesz, Brigitte Nuscher, Steffanie Heindl, Daniel Farny, Nikola Mareljic
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
EMBO Mol. Med. 12:e10919 (2020)
EMBO molecular medicine 12(2), e10919 (2020). doi:10.15252/emmm.201910919
EMBO Molecular Medicine
EMBO Mol. Med. 12:e10919 (2020)
EMBO molecular medicine 12(2), e10919 (2020). doi:10.15252/emmm.201910919
EMBO Molecular Medicine
The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical translation of the expanded repeat results in abundant poly‐GA inclusion pathology throughout
Autor:
Martin Hrabé de Angelis, Thomas Misgeld, Katherine D. LaClair, Monika S. Brill, Manuela Neumann, Qihui Zhou, Meike Michaelsen, Aleksandar Janjic, Wolfgang Enard, Wolfgang Wurst, Daniel Farny, Benedikt Wefers, Birgit Rathkolb, Mikolaj Cygan, Dieter Edbauer, Thomas Arzberger
Publikováno v:
Acta Neuropathol. 140, 121–142 (2020)
Acta neuropathologica 140(2), 121-142 (2020). doi:10.1007/s00401-020-02176-0
Acta Neuropathologica
Acta neuropathologica 140(2), 121-142 (2020). doi:10.1007/s00401-020-02176-0
Acta Neuropathologica
Expansion of a (G4C2)n repeat in C9orf72 causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the link of the five repeat-encoded dipeptide repeat (DPR) proteins to neuroinflammation, TDP-43 pathology, and neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49fb2804712e9500696e36c93f162a1
https://mediatum.ub.tum.de/1578105
https://mediatum.ub.tum.de/1578105
Autor:
Hannelore, Hartmann, Daniel, Hornburg, Mareike, Czuppa, Jakob, Bader, Meike, Michaelsen, Daniel, Farny, Thomas, Arzberger, Matthias, Mann, Felix, Meissner, Dieter, Edbauer
Publikováno v:
Life Science Alliance
Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show