Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Daniel, Falush"'
Autor:
Aidan J. Taylor, Koji Yahara, Ben Pascoe, Seungwon Ko, Leonardos Mageiros, Evangelos Mourkas, Jessica K. Calland, Santeri Puranen, Matthew D. Hitchings, Keith A. Jolley, Carolin M. Kobras, Sion Bayliss, Nicola J. Williams, Arnoud H. M. van Vliet, Julian Parkhill, Martin C. J. Maiden, Jukka Corander, Laurence D. Hurst, Daniel Falush, Paul Keim, Xavier Didelot, David J. Kelly, Samuel K. Sheppard
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (a
Externí odkaz:
https://doaj.org/article/b01240a0b60f44418e276da053e1f0fe
Autor:
Kaisa Thorell, Zilia Y. Muñoz-Ramírez, Difei Wang, Santiago Sandoval-Motta, Rajiv Boscolo Agostini, Silvia Ghirotto, Roberto C. Torres, HpGP Research Network, Daniel Falush, M. Constanza Camargo, Charles S. Rabkin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host
Externí odkaz:
https://doaj.org/article/ae6c181692004c09bbdb55bf0bf8559f
Autor:
Harry A. Thorpe, Elise Tourrette, Koji Yahara, Filipa F. Vale, Siqi Liu, Mónica Oleastro, Teresa Alarcon, Tsachi-Tsadok Perets, Saeid Latifi-Navid, Yoshio Yamaoka, Beatriz Martinez-Gonzalez, Ioannis Karayiannis, Timokratis Karamitros, Dionyssios N. Sgouras, Wael Elamin, Ben Pascoe, Samuel K. Sheppard, Jukka Ronkainen, Pertti Aro, Lars Engstrand, Lars Agreus, Sebastian Suerbaum, Kaisa Thorell, Daniel Falush
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Helicobacter pylori is a major human pathogen whose population structure is similar to that of its host. Here, the authors show that H. pylori has repeatedly spread out of Africa recently, replacing deleterious variants that accumulated during the or
Externí odkaz:
https://doaj.org/article/54287d44e6a344f886d3d297e6a9f657
Autor:
Daniel Falush
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud,
Externí odkaz:
https://doaj.org/article/4aa6ae1d51614dfb9279ca22caa588bb
Autor:
Harry A. Thorpe, Elise Tourrette, Koji Yahara, Filipa F. Vale, Siqi Liu, Mónica Oleastro, Teresa Alarcon, Tsachi-Tsadok Perets, Saeid Latifi-Navid, Yoshio Yamaoka, Beatriz Martinez-Gonzalez, Ioannis Karayiannis, Timokratis Karamitros, Dionyssios N. Sgouras, Wael Elamin, Ben Pascoe, Samuel K. Sheppard, Jukka Ronkainen, Pertti Aro, Lars Engstrand, Lars Agreus, Sebastian Suerbaum, Kaisa Thorell, Daniel Falush
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/25c6cc6f8bd84742943ca0a3a9ed13a5
Autor:
Nicolai Karcher, Edoardo Pasolli, Francesco Asnicar, Kun D. Huang, Adrian Tett, Serena Manara, Federica Armanini, Debbie Bain, Sylvia H. Duncan, Petra Louis, Moreno Zolfo, Paolo Manghi, Mireia Valles-Colomer, Roberta Raffaetà, Omar Rota-Stabelli, Maria Carmen Collado, Georg Zeller, Daniel Falush, Frank Maixner, Alan W. Walker, Curtis Huttenhower, Nicola Segata
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract Background Eubacterium rectale is one of the most prevalent human gut bacteria, but its diversity and population genetics are not well understood because large-scale whole-genome investigations of this microbe have not been carried out. Resu
Externí odkaz:
https://doaj.org/article/f32fcb210c9e4d5b862390f89e7cb781
Autor:
Jessica K Calland, Ben Pascoe, Sion C Bayliss, Evangelos Mourkas, Elvire Berthenet, Harry A Thorpe, Matthew D Hitchings, Edward J Feil, Jukka Corander, Martin J Blaser, Daniel Falush, Samuel K Sheppard
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009829 (2021)
Measuring molecular evolution in bacteria typically requires estimation of the rate at which nucleotide changes accumulate in strains sampled at different times that share a common ancestor. This approach has been useful for dating ecological and evo
Externí odkaz:
https://doaj.org/article/41191db470e540458ae06371ac449ca4
Publikováno v:
eLife, Vol 9 (2020)
Investigating fitness interactions in natural populations remains a considerable challenge. We take advantage of the unique population structure of Vibrio parahaemolyticus, a bacterial pathogen of humans and shrimp, to perform a genome-wide screen fo
Externí odkaz:
https://doaj.org/article/04bdde78192847209a1abee58baf4bc0
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Clustering methods such as STRUCTURE and ADMIXTURE are widely used in population genetic studies to investigate ancestry. Here, the authors provide a tutorial on how to interpret results of these analyses and a tool to test the goodness of fit of the
Externí odkaz:
https://doaj.org/article/9f866be649da4366be19ab5ea0fe6159
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
Autor:
Elvire Berthenet, Koji Yahara, Kaisa Thorell, Ben Pascoe, Guillaume Meric, Jane M. Mikhail, Lars Engstrand, Helena Enroth, Alain Burette, Francis Megraud, Christine Varon, John C Atherton, Sinead Smith, Thomas S. Wilkinson, Matthew D. Hitchings, Daniel Falush, Samuel K. Sheppard
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epide
Externí odkaz:
https://doaj.org/article/abcb3e36555b4a2083954b07384bc0f7