Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Daniel, Emerling"'
Autor:
Gregory M. Martin, Jonathan L. Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re’em Moskovitz, Nathan Beutler, Diana D. Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S. MacGill, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The generation of high-quality antibody responses to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is paramount to the development of an effective malaria vaccine. Here we present
Externí odkaz:
https://doaj.org/article/9852dbd3db8d470488cfc46ea2bb7db5
Autor:
Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Gonzalo Gonzalez-Paez, Zhen Han, Katherine L. Williams, Wayne Volkmuth, Daniel Emerling, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to un
Externí odkaz:
https://doaj.org/article/f69e762087b34c9ba0a1c8a3d1c005e9
Autor:
Nathan Beutler, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Randall S MacGill, Elijah Garcia, Jaeson Calla, Mara Parren, Linlin Yang, Wayne Volkmuth, Emily Locke, Jason A Regules, Sheetij Dutta, Daniel Emerling, Angela M Early, Daniel E Neafsey, Elizabeth A Winzeler, C Richter King, Fidel Zavala, Dennis R Burton, Ian A Wilson, Thomas F Rogers
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010409 (2022)
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in en
Externí odkaz:
https://doaj.org/article/466c773f347b462fb6e06036904736dc
Autor:
Brandon McLeod, Kazutoyo Miura, Stephen W. Scally, Alexandre Bosch, Ngan Nguyen, Hanjun Shin, Dongkyoon Kim, Wayne Volkmuth, Sebastian Rämisch, Jessica A. Chichester, Stephen Streatfield, Colleen Woods, William R. Schief, Daniel Emerling, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Pfs25 is a transmission-blocking vaccine candidate for Plasmodium. Here, McLeod et al. analyze the antibody response to Pfs25 in sera from a clinical trial evaluating a Pfs25 vaccine candidate, identify a potent transmission-blocking antibody and det
Externí odkaz:
https://doaj.org/article/67758bcac9e4447fab4577c5f6b5c7a0
Autor:
Marta Casal, Moura, Gwen E, Thompson, Darlene R, Nelson, Lynn A, Fussner, Amber M, Hummel, Dieter E, Jenne, Daniel, Emerling, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, W Joseph, McCune, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, E William, St Clair, Steven R, Ytterberg, John H, Stone, William H, Robinson, Ulrich, Specks
Publikováno v:
Arthritis & Rheumatology. 75:748-759
Proteinase 3 (PR3) is the major antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) in the systemic autoimmune vasculitis, granulomatosis with polyangiitis (GPA). PR3 anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) recognize different epito
Autor:
Felix Chu, Michael Harbell, Amy Manning-Bog, Alexander Scholz, Ngan Nguyen, Norman Greenberg, William Robinson, Daniel Emerling, Tito Serafini, Wei Cao, Yvonne Leung, Nikhil Vad, Anne Ye, Daniel Santos, Cathrin Czupalla, John Vivian, Carlene Williams, Judevin Sapugay, Shaun Lippow, Chantia Carroll, Lance Kates, Benjamin Haugen, Gary Bolton, Mark Armanini, Iraz Aydin, Mark Whidden, Mauricio Velasco-Delgado, Erin Wechsler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/d68b61ac36ac49e5b4d60c03de821131
Autor:
David Oyen, Jonathan L Torres, Phillip C Aoto, Yevel Flores-Garcia, Špela Binter, Tossapol Pholcharee, Sean Carroll, Sini Reponen, Rachael Wash, Qi Liang, Franck Lemiale, Emily Locke, Allan Bradley, C Richter King, Daniel Emerling, Paul Kellam, Fidel Zavala, Andrew B Ward, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies s
Externí odkaz:
https://doaj.org/article/2b45fbb0cb2843a2913970e92e8e5bed
Autor:
Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura, Qi Liang, Sean Carroll, Sini Reponen, Ngan Nguyen, Eldar Giladi, Sebastian Rämisch, Vidadi Yusibov, Allan Bradley, Franck Lemiale, William R. Schief, Daniel Emerling, Paul Kellam, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicit
Externí odkaz:
https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d
Autor:
Yuan-Ping Pang, Marta Casal Moura, Gwen E. Thompson, Darlene R. Nelson, Amber M. Hummel, Dieter E. Jenne, Daniel Emerling, Wayne Volkmuth, William H. Robinson, Ulrich Specks
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in
Externí odkaz:
https://doaj.org/article/315a254bfbd1410fbcbda94f11de70d8
Autor:
Katherine Williams, Steve Guerrero, Yevel Flores-Garcia, Kayla Andrews, Dongkyoon Kim, Kevin Williamson, Christine Siska, Pauline Smidt, Sofia Jepson, Hong Liu, Kan Li, S Dennison, Shamika Mathis-Torres, Xiaomu Chen, Ulrike Wille-Reece, Randall MacGill, Michael Walker, Erik Jongert, C King, Christian Ockenhouse, Jacob Glanville, James Moon, Jason Regules, Yann Chong Tan, Guy Cavet, Shaun Lippow, William Robinson, Sheetij Dutta, Georgia Tomaras, Fidel Zavala, Randal Ketchem, Daniel Emerling
Over 80% of malaria-attributable deaths are in children under five. However, the only malaria vaccine recommended by the World Health Organization (WHO) for paediatric use, Mosquirix™, has limited efficacy. Complementary strategies, like monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f9980d309fc1b7d1fee26175f1b3f6
https://doi.org/10.21203/rs.3.rs-2678519/v1
https://doi.org/10.21203/rs.3.rs-2678519/v1