Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Daniel, Durocher"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Mara De Marco Zompit, Mònica Torres Esteban, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.
Externí odkaz:
https://doaj.org/article/6bb76f98748d456bb28f51f91a387637
Autor:
Daniel Durocher, MD, Imane El-Hajjaji, MBBS, Syed O. Gilani, MD, Peter Leong-Sit, MD, MSc, Ryan A. Davey, MD, Sabe K. De, MD
Publikováno v:
CJC Open, Vol 3, Iss 12, Pp 1509-1512 (2021)
Differentiating between sarcoidosis and giant cell myocarditis (GCM) based on clinical presentation is difficult. We present the case of a 57-year-old woman who was initially diagnosed with GCM based on endomyocardial biopsy. The patient was refracto
Externí odkaz:
https://doaj.org/article/a3265e9886c340baa140307d615dc9ff
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su
Externí odkaz:
https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
Autor:
Johnny M Tkach, Reuben Philip, Amit Sharma, Jonathan Strecker, Daniel Durocher, Laurence Pelletier
Publikováno v:
eLife, Vol 11 (2022)
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the r
Externí odkaz:
https://doaj.org/article/fc695c50222a47249da3873639dc6225
Autor:
Jonah Beenstock, Samara Mishelle Ona, Jennifer Porat, Stephen Orlicky, Leo C. K. Wan, Derek F. Ceccarelli, Pierre Maisonneuve, Rachel K. Szilard, Zhe Yin, Dheva Setiaputra, Daniel Y. L. Mao, Morgan Khan, Shaunak Raval, David C. Schriemer, Mark A. Bayfield, Daniel Durocher, Frank Sicheri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
KEOPS is an evolutionary conserved complex with a core of four core subunits—Pcc1, Kae1, Bud32 and Cgi121—that catalyzes the universal and essential tRNA modification N6-threonylcarbamoyl adenosine (t6A). Here the authors describe a Cgi121-tRNA c
Externí odkaz:
https://doaj.org/article/7cf78e57b0794aac8b3b0de7021b5c2b
Autor:
Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistan
Externí odkaz:
https://doaj.org/article/0660691297e4473f951c2f4ee9ed5f00
Autor:
Michele Olivieri, Daniel Durocher
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100321- (2021)
Summary: CRISPR-based genetic screens revolutionized our ability to genetically probe cell biology. We present a protocol to conduct genome-scale chemogenomic dropout CRISPR screens in the human RPE1-hTERT p53−/− cell line. We use the TKOv3 libra
Externí odkaz:
https://doaj.org/article/6f61fec1e3884144b21c9e3290443455
Autor:
J Javier Díaz‐Mejía, Albi Celaj, Joseph C Mellor, Atina Coté, Attila Balint, Brandon Ho, Pritpal Bansal, Fatemeh Shaeri, Marinella Gebbia, Jochen Weile, Marta Verby, Anna Karkhanina, YiFan Zhang, Cassandra Wong, Justin Rich, D'Arcy Prendergast, Gaurav Gupta, Sedide Öztürk, Daniel Durocher, Grant W Brown, Frederick P Roth
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 5, Pp 1-17 (2018)
Abstract Condition‐dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions. State‐of‐the‐art yeast genetic interaction mapping, which relies on robotic manipulati
Externí odkaz:
https://doaj.org/article/2cc42bd94f72421daa7d032148d66de4
Autor:
Nicole L. Batenburg, John R. Walker, Sylvie M. Noordermeer, Nathalie Moatti, Daniel Durocher, Xu-Dong Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Cockayne syndrome group B protein (CSB) is a multifunctional chromatin remodeler involved in double-strand break repair. Here the authors investigate the molecular post-translational signals regulating CSB activity.
Externí odkaz:
https://doaj.org/article/e4816a9ac34e4a8cb9e3e31109884db4