Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel, Doheny"'
Autor:
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Publikováno v:
Cancer Lett
Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d1602303d3b2100122e04793288c7
https://doi.org/10.1016/j.canlet.2022.01.029
https://doi.org/10.1016/j.canlet.2022.01.029
Publikováno v:
Cells, Vol 9, Iss 9, p 2114 (2020)
The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a consequence of improper control, aberrant HH signaling results in tumorigenesis and supports aggressive phenotypes of human cancers, such as neoplastic transfo
Externí odkaz:
https://doaj.org/article/93aa582e76204237a4d62b80584a8fb4
Publikováno v:
Cancer Lett
Transgenic breast cancer mouse models are critical tools for preclinical studies of human breast cancer. Genetic editing of the murine mammary gland allows for modeling of abnormal genetic events frequently found in human breast cancers. Genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb59c25746d200d82030ae8dbf2f838
https://doi.org/10.1016/j.canlet.2021.05.027
https://doi.org/10.1016/j.canlet.2021.05.027
Autor:
Daniel Doheny, Sara Manore, Sherona R. Sirkisoon, Dongqin Zhu, Noah R. Aguayo, Alexandria Harrison, Mariana Najjar, Marlyn Anguelov, Anderson O’Brien Cox, Cristina M. Furdui, Kounosuke Watabe, Thomas Hollis, Alexandra Thomas, Roy Strowd, Hui-Wen Lo
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4256
The goal of this study is to identify pharmacological inhibitors that target a recently identified novel mediator of breast cancer brain metastasis (BCBM), truncated glioma-associated oncogene homolog 1 (tGLI1). Inhibitors of tGLI1 are not yet availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0cfbebb491e653607578294e7940f2
https://doi.org/10.3390/cancers14174256
https://doi.org/10.3390/cancers14174256
Autor:
Angelina T. Regua, Grace L. Wong, Austin Arrigo, Sara Abu Jalboush, Jiayuh Lin, Alexandra Thomas, Jimmy Ruiz, Roy E. Strowd, Sara G. Manore, Daniel Doheny, Yang Yu, Noah R. Aguayo, Dongqin Zhu, Calvin J. Wagner, Guangxu Jin, Peiqing Sun, Michael D. Chan, Hui-Wen Lo
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2340, p 2340 (2021)
Volume 13
Issue 10
Cancers, Vol 13, Iss 2340, p 2340 (2021)
Volume 13
Issue 10
JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers
however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first
however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca55504ccc6cefa2f5d7909c922d017
https://pubmed.ncbi.nlm.nih.gov/34066153
https://pubmed.ncbi.nlm.nih.gov/34066153
Autor:
Daniel Doheny, Sara Manore, Grace L. Wong, Dongqin Zhu, Sherona Sirkisoon, Marlyn Anguelov, Noah R. Augayo, Angelina T. Regua, Anderson Cox, Cristina Furdui, Terrence Smalley, Alexandra Thomas, Adrianna Masters, Roy E. Strowd, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:2433-2433
Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months after diagnosis. Novel agents that act on targetable driver mutations (EGFR, PI3K, etc.) and penetrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8517d981289dbc699cc1614dbc6ff842
https://doi.org/10.1158/1538-7445.am2022-2433
https://doi.org/10.1158/1538-7445.am2022-2433
Publikováno v:
Cells
Cells, Vol 9, Iss 2114, p 2114 (2020)
Cells, Vol 9, Iss 2114, p 2114 (2020)
The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a consequence of improper control, aberrant HH signaling results in tumorigenesis and supports aggressive phenotypes of human cancers, such as neoplastic transfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2200bd7da3579b0c3ec0beda3ee6a0c2
http://europepmc.org/articles/PMC7565963
http://europepmc.org/articles/PMC7565963
Publikováno v:
Discovery medicine. 28(154)
Tropomyosin receptor kinases (TRKs) were first identified in 1986 when NTRK1 was discovered as part of an oncogenic fusion gene in colorectal cancer and the discovery of NTRK2 and NTRK3 followed shortly after. In the decades since their discovery, TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a41e35ecf7d485d964097bb4a4aa11f2
https://pubmed.ncbi.nlm.nih.gov/31928627
https://pubmed.ncbi.nlm.nih.gov/31928627
Autor:
Gina Song, Briana Foley, Tyler Beames, Daniel Doheny, Jessica K. Hartman, Patrick D. McMullen, Bethany Parks, Miyoung Yoon, Chad Deisenroth, Rebecca A. Clewell, Alina Efremenko
Publikováno v:
Toxicology and Applied Pharmacology. 355:112-126
Rising obesity rates worldwide have socio-economic ramifications. While genetics, diet, and lack of exercise are major contributors to obesity, environmental factors may enhance susceptibility through disruption of hormone homeostasis and metabolic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbf52c6aa441ef5df5e920265a0f0dd
https://doi.org/10.1016/j.taap.2018.05.016
https://doi.org/10.1016/j.taap.2018.05.016
Autor:
Hui-Wen Lo, Kounosuke Watabe, Dongqin Zhu, Alexandra Thomas, Adrianna H. Masters, Fei Xing, Marlyn Anguelov, Noah R. Aguayo, Tadas Rimkus, Daniel Doheny, Linda J. Metheny-Barlow, Sherona Sirkisoon, Roy E. Strowd, Sara G. Manore
Publikováno v:
Cancer Research. 81:2866-2866
Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months following diagnosis. Current standard of care options for BCBM include stereotactic radiosurgery, who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79430d0291bc3b5c23c58dca3d2633b7
https://doi.org/10.1158/1538-7445.am2021-2866
https://doi.org/10.1158/1538-7445.am2021-2866