Zobrazeno 1 - 10
of 609
pro vyhledávání: '"Daniel, Catovsky"'
Autor:
Tomasz K. Wojdacz, Harindra E. Amarasinghe, Latha Kadalayil, Alice Beattie, Jade Forster, Stuart J. Blakemore, Helen Parker, Dean Bryant, Marta Larrayoz, Ruth Clifford, Pauline Robbe, Zadie A. Davis, Monica Else, Dena R. Howard, Basile Stamatopoulos, Andrew J. Steele, Richard Rosenquist, Andrew Collins, Andrew R. Pettitt, Peter Hillmen, Christoph Plass, Anna Schuh, Daniel Catovsky, David G. Oscier, Matthew J.J. Rose-Zerilli, Christopher C. Oakes, Jonathan C. Strefford
Publikováno v:
Blood Advances, Vol 3, Iss 16, Pp 2474-2481 (2019)
Abstract: Chronic lymphocytic leukemia patients with mutated immunoglobulin heavy-chain genes (IGHV-M), particularly those lacking poor-risk genomic lesions, often respond well to chemoimmunotherapy (CIT). DNA methylation profiling can subdivide earl
Externí odkaz:
https://doaj.org/article/cd01b8a978aa4041a72a417cc4cb4fcc
Autor:
Helen E. Speedy, Renée Beekman, Vicente Chapaprieta, Giulia Orlando, Philip J. Law, David Martín-García, Jesús Gutiérrez-Abril, Daniel Catovsky, Sílvia Beà, Guillem Clot, Montserrat Puiggròs, David Torrents, Xose S. Puente, James M. Allan, Carlos López-Otín, Elias Campo, Richard S. Houlston, José I. Martín-Subero
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show ac
Externí odkaz:
https://doaj.org/article/9b5b6327af3c440e9c59830da14206ad
Autor:
Philip J. Law, Sonja I. Berndt, Helen E. Speedy, Nicola J. Camp, Georgina P. Sava, Christine F. Skibola, Amy Holroyd, Vijai Joseph, Nicola J. Sunter, Alexandra Nieters, Silvia Bea, Alain Monnereau, David Martin-Garcia, Lynn R. Goldin, Guillem Clot, Lauren R. Teras, Inés Quintela, Brenda M. Birmann, Sandrine Jayne, Wendy Cozen, Aneela Majid, Karin E. Smedby, Qing Lan, Claire Dearden, Angela R. Brooks-Wilson, Andrew G. Hall, Mark P. Purdue, Tryfonia Mainou-Fowler, Claire M. Vajdic, Graham H. Jackson, Pierluigi Cocco, Helen Marr, Yawei Zhang, Tongzhang Zheng, Graham G. Giles, Charles Lawrence, Timothy G. Call, Mark Liebow, Mads Melbye, Bengt Glimelius, Larry Mansouri, Martha Glenn, Karen Curtin, W Ryan Diver, Brian K. Link, Lucia Conde, Paige M. Bracci, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Demetrius Albanes, Stephanie Weinstein, Zhaoming Wang, Neil E. Caporaso, Lindsay M. Morton, Richard K. Severson, Elio Riboli, Paolo Vineis, Roel C. H. Vermeulen, Melissa C. Southey, Roger L. Milne, Jacqueline Clavel, Sabine Topka, John J. Spinelli, Peter Kraft, Maria Grazia Ennas, Geoffrey Summerfield, Giovanni M. Ferri, Robert J. Harris, Lucia Miligi, Andrew R. Pettitt, Kari E. North, David J. Allsup, Joseph F. Fraumeni, James R. Bailey, Kenneth Offit, Guy Pratt, Henrik Hjalgrim, Chris Pepper, Stephen J. Chanock, Chris Fegan, Richard Rosenquist, Silvia de Sanjose, Angel Carracedo, Martin J. S. Dyer, Daniel Catovsky, Elias Campo, James R. Cerhan, James M. Allan, Nathanial Rothman, Richard Houlston, Susan Slager
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune fun
Externí odkaz:
https://doaj.org/article/7260f008ee8e4abd981c7eed2433bb15
Autor:
Alessandro Broccoli, Lisa Argnani, Matthew Cross, Agnieszka Janus, Elsa Maitre, Xavier Troussard, Tadeusz Robak, Claire Dearden, Monica Else, Daniel Catovsky, Pier Luigi Zinzani
Publikováno v:
Blood Advances. 6:4224-4227
Key Points Cladribine is regarded as the first treatment of choice for symptomatic hairy cell leukemia. This large international study reports a complete response in 72% of cases and a continuous complete response in 20% of patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44706199d3d4fdd0a2167fa02821c6a6
https://doi.org/10.1182/bloodadvances.2022007854
https://doi.org/10.1182/bloodadvances.2022007854
Autor:
Radhika Kandaswamy, Georgina P. Sava, Helen E. Speedy, Sílvia Beà, José I. Martín-Subero, James B. Studd, Gabriele Migliorini, Philip J. Law, Xose S. Puente, David Martín-García, Itziar Salaverria, Jesús Gutiérrez-Abril, Carlos López-Otín, Daniel Catovsky, James M. Allan, Elías Campo, Richard S. Houlston
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2061-2067 (2016)
Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which it influences tumorigenesis.
Externí odkaz:
https://doaj.org/article/e91cfff18d49416982e8980133481082
Autor:
Andrew R. Pettitt, Daniel Catovsky, David G. Oscier, Claire Dearden, Estella Matutes, David Gonzalez, Sue Richards, Rachel Wade, Melanie Oates, Anthony Carter, Gillian G. Johnson, Janet Adamson, Ke Lin
Purpose: This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f40a111844ca7e09b6f94cf5f72ac22
https://doi.org/10.1158/1078-0432.c.6519972
https://doi.org/10.1158/1078-0432.c.6519972
Autor:
Andrew R. Pettitt, Daniel Catovsky, David G. Oscier, Claire Dearden, Estella Matutes, David Gonzalez, Sue Richards, Rachel Wade, Melanie Oates, Anthony Carter, Gillian G. Johnson, Janet Adamson, Ke Lin
PDF file - 442K, Functional Analysis of the ATM-p53-p21 pathway in CLL4 trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4fc477fef7018fc868097ea41154ad
https://doi.org/10.1158/1078-0432.22443819.v1
https://doi.org/10.1158/1078-0432.22443819.v1
Publikováno v:
Leukemia
Causes of death, in particular deaths due to infection, have not been widely studied in randomised trials in chronic lymphocytic leukaemia. With long-term follow-up (median 13 years) we examined the cause of death in 600/777 patients in the LRF CLL4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d715be446a00d3c84655cffbadd4121
https://doi.org/10.1038/s41375-021-01165-w
https://doi.org/10.1038/s41375-021-01165-w
Autor:
Riccardo Bomben, Chris Pepper, Zarni Soe, Kevin Norris, David Allsup, Jerry Polesel, Christopher Fegan, Pei Loo Ow, Andy C. Rawstron, Daniel Catovsky, Anna Hockaday, Antonella Zucchetto, Andrea Pepper, Peter Hillmen, Pietro Bulian, Erika Tissino, Duncan M. Baird, Valter Gattei
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef924c15eb918bddabc57a7425d7c7e
http://sro.sussex.ac.uk/id/eprint/100090/1/s41375-021-01322-1.pdf
http://sro.sussex.ac.uk/id/eprint/100090/1/s41375-021-01322-1.pdf
Publikováno v:
Haematologica, Vol 99, Iss 6 (2014)
We examined the prognostic influence of gender in chronic lymphocytic leukemia. Data from four randomized trials (involving 1821 patients) and three registration studies of stage-A disease (involving 1299 patients) were analyzed. Overall survival at
Externí odkaz:
https://doaj.org/article/a4574636a5eb447cb028ba2086581edd