Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Daniel, Abankwa"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Tumour suppressors are inhibited in cancers and their reactivation could provide novel therapy opportunities. Here, the authors study the structural mechanism by which human tumour suppressor Protein Phosphatase 2A is inhibited in breast cancer cells
Externí odkaz:
https://doaj.org/article/a40d0289287e4365ac202e20daf82ec2
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151314- (2023)
The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane. We now know that Ras is non-randomly organi
Externí odkaz:
https://doaj.org/article/ffd7ea454cd94434b1090fcb4a1ab995
Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells.
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268635 (2022)
Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors, notably dopamine receptors. Because of this activity they have been used for decades as antipsychotic drugs. In addition, they possess significant anti-cancer
Externí odkaz:
https://doaj.org/article/ad1b7d24cf334e32b3c3f829e685e807
Autor:
Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemn
Externí odkaz:
https://doaj.org/article/9ea10ad1355044e0be26a3d195bb37dc
Autor:
Farid A. Siddiqui, Catharina Alam, Petja Rosenqvist, Mikko Ora, Ahmed Sabt, Ganesh babu Manoharan, Lakshman Bindu, Sunday Okutachi, Marie Catillon, Troy Taylor, Omaima M. Abdelhafez, Harri Lönnberg, Andrew G. Stephen, Anastassios C. Papageorgiou, Pasi Virta, Daniel Abankwa
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
Externí odkaz:
https://doaj.org/article/3c425549098741d9ab67574c49453cfb
Publikováno v:
Biochemical Society Transactions. 51:447-456
RAS drug development has made enormous strides in the past ten years, with the first direct KRAS inhibitor being approved in 2021. However, despite the clinical success of covalent KRAS-G12C inhibitors, we are immediately confronted with resistances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24f9df84b6601766900c8063de8aa8d
https://doi.org/10.1042/bst20221343
https://doi.org/10.1042/bst20221343
Autor:
Claudia Cipriani, Maria Pires Pacheco, Ali Kishk, Maryem Wachich, Daniel Abankwa, Elisabeth Schaffner-Reckinger, Thomas Sauter
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 179 (2022)
The multi-target effects of natural products allow us to fight complex diseases like cancer on multiple fronts. Unlike docking techniques, network-based approaches such as genome-scale metabolic modelling can capture multi-target effects. However, th
Externí odkaz:
https://doaj.org/article/67c98c6895404caeb2d4ae57a13ec53e
Autor:
Itziar M. D. Posada, Benoit Lectez, Farid A. Siddiqui, Christina Oetken-Lindholm, Mukund Sharma, Daniel Abankwa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract As a major growth factor transducer, Ras is an upstream activator of mTORC1, which further integrates nutrient and energy inputs. To ensure a contextual coupling of cell division via Ras/MAPK-signalling and growth via mTORC1-signalling, feed
Externí odkaz:
https://doaj.org/article/37bdb60d533147c484ba87879ea57fcb
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 836 (2021)
The natural product elaiophylin is a macrodiolide with a broad range of biological activities. However, no direct target of elaiophylin in eukaryotes has been described so far, which hinders a systematic explanation of its astonishing activity range.
Externí odkaz:
https://doaj.org/article/2d8c2092bd934ab7affd11bf13ec7ff1