Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists

Autor: Danica E. DeGroot, Mark E. Hahn, Junichi Tanaka, Diana G. Franks, Michael S. Denison, Tatsuo Higa

Publikováno v: DeGroot, DE; Franks, DG; Higa, T; Tanaka, J; Hahn, ME; & Denison, MS. (2015). Naturally Occurring Marine Brominated Indoles Are Aryl Hydrocarbon Receptor Ligands/Agonists. Chemical Research in Toxicology, 28(6), 1176-1185. doi: 10.1021/acs.chemrestox.5b00003. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/8396q1z2
Chemical research in toxicology, vol 28, iss 6

© 2015 American Chemical Society. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates the toxic and biological effects of structurally diverse chemicals, including the environmental contaminant 2,3,7,8-tetrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38d32dfee315ed79336ae041f37eacf
https://pubmed.ncbi.nlm.nih.gov/26001051

Nucleotide Specificity of DNA Binding of the Aryl Hydrocarbon Receptor:ARNT Complex Is Unaffected by Ligand Structure

Autor: Danica E. DeGroot, Michael S. Denison

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology, vol 137, iss 1

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and a wide variety of structurally diverse ligands through its ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f1e06a4ac81b8fb038545d2405d7c0
https://europepmc.org/articles/PMC3924043/

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

Autor: Bin Zhao, Michael S. Denison, Danica E. DeGroot, Anatoly A. Soshilov, Guochun He

The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range of biological and toxicological effects that result from exposure to a structurally diverse variety of synthetic and naturally occurring chemicals. Although t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40f1662f62f6d298b88ead8a5aaa8db
https://europepmc.org/articles/PMC3196658/

Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts

Autor: Shelley Brown, DuTeaux, Matt J, Hengel, Danica E, DeGroot, Karen A, Jelks, Marion G, Miller

Publikováno v: Biology of reproduction. 69(3)

Recent studies indicate that trichloroethylene (TCE) may be a male reproductive toxicant. It is metabolized by conjugation with glutathione and cytochrome p450-dependent oxidation. Reactive metabolites produced along both pathways are capable of form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d2bc52e8801237175c5504a9302b624
https://pubmed.ncbi.nlm.nih.gov/12724279