Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells

Autor: Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Ming Li, Mark R. Chance, John C. Tilton

Publikováno v: Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)

Abstract Background Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascade is initiated that r

Externí odkaz: https://doaj.org/article/6084940092b8472e83a9ecc95a8d5774

Expression-Based Cell Lineage Analysis inDrosophilaThrough a Course-Based Research Experience for Early Undergraduates

Autor: Daniel Chang, Earl Yoon, David Loppato, Justin N. Maghen, Silverio D. Alvarez, Kristy Ou, Katherine E. Peterson, Manjeet Bhamra, Helen H.-L. Chan, Lilit Gevorgyan, Clifton Lee, Peter Trinh, David M. Li, Elizabeth Kim, Garrick Iwamoto, Yue Zhao, Victor W. Yee, Kimberly Gon, Lisa M. Scully, Akram V. Uraizee, Sangita Datta, Sae Ho Song, Lisa Han, Andrew C. J. Huang, PhuongThao Tran, George K. Yeh, John M. Olson, Shawn J. Kim, Lili Sadri, Hannah G. Ahn, Grace E. Lee, Cindy L. Trang, Arezou Babaesfahani, Stephanie Wang, Saif Ansari, Hanwool Kim, Rakesh Bhatia, Brandon Lung, Victoria Ragland, Noemi E. Lee, Casey Shapiro, Van Thanh Mai, Sean H. K. Lee, Holly Dickinson, Joseph Park, Rona Law, Carrou Lee, Cameron M. Rice, Kirandeep Sumra, Alexandra L. Pourzia, Raj Dhaliwal, Vijay A. Patel, Michael Guillermo Daniel, Elaine L. Hsia, Hiu Wai Lam, Yujin Park, Jason H. Melehani, Annie Tigranyan, Xin Zheng, Nasser Heyrani, Jennifer Chang, Neda Asem, Joseph Duy Nguyen, Hanh H. Nguyen, Ted T. Uotani, Harnek Singh, Riley Guerin, Han-Ching H. Tseng, Kevin K. T. Vu, Max Mittelman, Gregory E. Tong, Cynthia Yeh, Jonathan Tran, Steven V. Pham, Bryan Lau, Kenny Lee, Tulika Ghosh, Roger K. Lau, An Huynh Pham, Christopher M. From, Elizabeth B. Johnson, Bobby Asem, Abhik Banerjee, Utpal Banerjee, Derek J. Cheung, Kambria Nguyen, Zainab Saifee, Carmel M. Moazez, Hung G. Trinh, Hannah Kim, Sonja Darwish, Lu Chen, Sondra L. Snyder, Pei-Yun Kao, Kevin Chen, Youngho Cho, Joseph Hargan Calvopina, Neil D. Poria, Vanessa Shih, Danica D. Wiredja, Shuo Wang, Zunera Ghaznavi, Jenny Dinh, Andrew J. Kim, Simran Kahlon, Awais M. Khan, Yuyu Chen, Julie Ko, Elise M. Calonico, Joseph N. Dickan, Huy D. Le, Leslie Jaworski, Xingfu Liang, Brooke Scruggs, Marc Levis-Fitzgerald, Susie Moon, Sara K. Taylor, An An Jiang, Nicholas Bumacod, Siddharth Sukumar, Matthew G. Keehn, Aleksandar Kitich, Cheng-An Tony Chien, Alexander N. Patananan, Jesse J. Cheung, Ragini Bhargava, Michael J. Jang, Alana M. Chin, Nikki Villarasa, Carman Chan, Ami Patel, Stacy Hu, Chiaen Chang, Solomon Rojhani, Michelle J. Kim, Shivani K. Thaker, Daisuke Furukawa, Arunit Singh Chugh, Volker Hartenstein, Hao Li, Akash Bhakta, Khoa T. Truong-N, Mark Sy, Daniel Rothberg, Melinda Feng, Kristine Kim, Nicole A. Azarian, David J. Groves, Sravya Mallam, Man Ting Chou, Katelyn F. Sobotka, Kathy T. Ngo, Justin Hsueh, Jasmine Y. Chen, Jessica Chew, Ira E. Clark, Zhong Ye, Mark R. Cubberly, Komal Wadhwani, Sumedha Singh, Jonathan J. Caine, Tamir Sholklapper, Jane Kuon, Nicholas G. Kouzelos, Emmylou Dowling, Francie Diep, Carolyn Chu, Kalkidan K. Gurara, Isabella Niu, Yaelim A. Park, Yong Jun Lee, Ali R. Haghighi, Nauman Charania, Nitish Mittal, Chee Jia Chin, Ben Sprung-Keyser, Naseem Moridzadeh, Donald N. Allen, Virginia Chu, Cory J. Evans, Luke Berry, Ahmad Bahrami, Justin J. Houman, Jesse M. Zaretsky, Kimberly A. Passmore, Chris Iwuchukwu, Rebecca S. Wang, Christina Lee, David Roh, Hee Jong Kim, Szuyao Lee, Rameen S. Moridzadeh, Randi K. Oyama, Amy A. Patel, Regina Lee, Serena S. Luong, Manpreet Kaur, Dhruv Patel, Xi Xue, Johnny He, Seo-Kyung Oh, Sabrena M. Ahmadi, Angela W. Nieh, Anke Ziegenbalg, Thien Nguyen, Jacinda N. Tran, John Y. Yu, Brian S. Kim, Eric Lin, Omair Khan, Ross G. Kelley, Sung Kyu Lee, Jessica S. Ma, Tanya Hioe, Nicole B. Chew, Kayla G. H. Gurley, Mark R Murata, Jiwon Lee, Hande Tan, Andrew L. Wong, Michael Koenig, Sung-Ling D. Lee, In Young Choi, Daniel Sitz, Paluk K. Walia, Maggie K. Chu, Ke-Huan K. Chow, Jessica R. Ong, Michelle J. Lee, Jenny Huynh, Rachael Le, Riki D. Ranat, Griselda Yanez, Yung-Hsuan Yang, Molly Howland, Ross A. Kornberg, Agafe Saguros, Peter Lin, Jessie C. Wu, Rahul Kumar Ghosh, Anand D. Gandhi, Jaskaran Gill, Edward Kuoy, Tulsi Thakore, Ritika Dutta, Himaja Gaddipati, Truc Ta, Melissa E. Phuphanich, Stacey Lu, Suji Kim, Letty Liang, Megan J. Leong, Derrick M. Chu, Michelle M. Lin, Alejandro LaRiviere, Alexandra L. Havard, Subir Bhatia, Minh-Tu Do, Sarah Kang, Jon Alkali, Kent K. T. Vu, Brian A. Shin, Samira J. Akhave, Kirim Hong, Thomas A. Caldwell, Jonathan Hofman, Vivi Tran, Katherine Chuang, Paul D. Picard, Jay Wang, Nicole A. Calica, Tiffany Y. Lin, Ryan C. Miller, Ida Azizkhanian, Manjot Sandhu, Dhaval Dixit, Kaley Ngo, Daniel Wu, Halley C. Sullivan, Jasmine C. Huynh, Tirth Patel, Vivian Yip, Manish M. Padhiar, Li Ma, Ryen Castillo, Shivtaj Mann, Tuan D. Tran, Albert J. Chang, Kunal Thaker

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3791-3800 (2019)

A variety of genetic techniques have been devised to determine cell lineage relationships during tissue development. Some of these systems monitor cell lineages spatially and/or temporally without regard to gene expression by the cells, whereas other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c849eeea00632b032d1c96689c11a9
https://doi.org/10.1534/g3.119.400541

Performance evaluation and optimized reporting workflow for HIV diagnostic screening and confirmatory tests in a low prevalence setting.

Autor: Wiredja D; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States of America., Ritchie TA; Laboratory Information System, Stanford Health Care, Stanford, CA, United States of America., Tam G; Stanford Clinical Virology Laboratory, Stanford Health Care, Stanford, CA, United States of America., Hogan CA; British Columbia Centre for Disease Control, Vancouver, BC, Canada., Pinsky B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States of America; Stanford Clinical Virology Laboratory, Stanford Health Care, Stanford, CA, United States of America; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America., Shi RZ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States of America. Electronic address: rzshi@stanford.edu.

Publikováno v: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2021 Dec; Vol. 145, pp. 105020. Date of Electronic Publication: 2021 Oct 28.

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors.

Autor: O'Connor CM; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA., Leonard D; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Wiredja D; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA., Avelar RA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Wang Z; Department of Biological Structure, University of Washington, Seattle, WA, USA., Schlatzer D; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA., Bryson B; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Tokala E; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Taylor SE; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Upadhyay A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Sangodkar J; Department of Internal Medicine: Genetic Medicine, University of Michigan, Ann Arbor, MI, USA., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Westermarck J; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland., Xu W; Department of Biological Structure, University of Washington, Seattle, WA, USA., DiFeo A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA., Brautigan DL; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Haider S; Department of Pharmaceutical and Biological Chemistry, University College London, London, UK., Jackson M; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Narla G; Department of Internal Medicine: Genetic Medicine, University of Michigan, Ann Arbor, MI, USA. gnarla@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. gnarla@med.umich.edu.

Publikováno v: Oncogene [Oncogene] 2020 Jan; Vol. 39 (3), pp. 703-717. Date of Electronic Publication: 2019 Sep 20.

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.

Autor: McClinch K; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Avelar RA; Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, Ohio., Callejas D; Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, Ohio., Izadmehr S; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Wiredja D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Perl A; Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, Ohio., Sangodkar J; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Kastrinsky DB; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio., Schlatzer D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Cooper M; Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, Ohio., Kiselar J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Stachnik A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Yao S; Department of Medicine, Division of Endocrine, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York., Hoon D; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., McQuaid D; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Zaware N; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio., Gong Y; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Brautigan DL; Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia., Plymate SR; Department of Medicine, University of Washington School of Medicine, Seattle, Washington., Sprenger CCT; Department of Medicine, University of Washington School of Medicine, Seattle, Washington., Oh WK; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Levine AC; Department of Medicine, Division of Endocrine, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York., Kirschenbaum A; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York., Sfakianos JP; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York., Sears R; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon., DiFeo A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio., Ioannou Y; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Ohlmeyer M; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio., Narla G; Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, Ohio. matthew.galsky@mssm.edu goutham.narla@case.edu.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio., Galsky MD; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. matthew.galsky@mssm.edu goutham.narla@case.edu.

Publikováno v: Cancer research [Cancer Res] 2018 Apr 15; Vol. 78 (8), pp. 2065-2080. Date of Electronic Publication: 2018 Jan 22.