Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux

Autor: Werner J.H. Koopman, Frans G. M. Russel, Dania C. Liemburg-Apers, Peter H.G.M. Willems, Tom J.J. Schirris

Publikováno v: Biophysical Journal, 109, 1372-86
Biophysical Journal, 109, 7, pp. 1372-86

Contains fulltext : 152488.pdf (Publisher’s version ) (Closed access) ATP can be produced in the cytosol by glycolytic conversion of glucose (GLC) into pyruvate. The latter can be metabolized into lactate, which is released by the cell, or taken up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd573a230d3fcd0c0c0eb357c6a12e81
https://doi.org/10.1016/j.bpj.2015.08.002

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-alpha

Autor: Annette Seibt, Richard J. Rodenburg, Felix Distelmaier, Katharina Danhauser, Mariusz R. Wieckowski, Peter H.G.M. Willems, Werner J.H. Koopman, Jack A.M. Fransen, Magdalena Lebiedzinska, Jaap Keijer, Dania C. Liemburg-Apers, Jan A.M. Smeitink, Sandra G. Heil, Frank N. Gellerich, Benoit Viollet, Hiromi Imamura, Federica Valsecchi

Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease, 1852, 529-40
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1852, 3, pp. 529-40
Biochimica et Biophysica Acta. Molecular Basis of Disease 1852 (2015) 3
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1852(3), 529-540

Contains fulltext : 153406.pdf (Publisher’s version ) (Closed access) Dysfunction of complex I (CI) of the mitochondrial electron transport chain (ETC) features prominently in human pathology. Cell models of ETC dysfunction display adaptive surviva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b699cb6828bd4be03b1ad3c5de3193b1
http://hdl.handle.net/2066/153406

Quantitative glucose and ATP sensing in mammalian cells

Autor: Marco Nooteboom, Werner J.H. Koopman, Marleen Forkink, Dania C. Liemburg-Apers, Herman G.P. Swarts, Jan A.M. Smeitink, Peter H.G.M. Willems, Roland Brock, Hiromi Imamura

Publikováno v: Pharmaceutical Research, 28, 2745-57
Pharmaceutical Research, 28, 11, pp. 2745-57

Contains fulltext : 98278.pdf (Publisher’s version ) (Closed access) The functioning and survival of mammalian cells requires an active energy metabolism. Metabolic dysfunction plays an important role in many human diseases, including diabetes, can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0128a755e9f6b1820e92c4a69c38a5
http://hdl.handle.net/2066/98278