Karyotype evolution in response to chemoradiotherapy and upon recurrence of esophageal adenocarcinomas

Autor: Karen van der Sluis, Johanna W. van Sandick, Willem J. Koemans, Tom van den Bosch, Annegien Broeks, Dennis Peters, Iris M. Seignette, Christian R. Rausch, Erik van Dijk, Petur Snaebjornsson, José G. van den Berg, Nicole C.T. van Grieken, Bauke Ylstra, Beatriz Carvalho, Daniël M. Miedema, Liudmila L. Kodach

Publikováno v: Cell Reports, Vol 43, Iss 11, Pp 114981- (2024)

Summary: The genome of esophageal adenocarcinoma (EAC) is highly unstable and might evolve over time. Here, we track karyotype evolution in EACs in response to treatment and upon recurrence through multi-region and longitudinal analysis. To this end,

Externí odkaz: https://doaj.org/article/27c918559ce54d819ad7fc6fb11a4b9a

Predicting survival of cancer patients by chromosomal copy number heterogeneity

Autor: Tom Van Den Bosch, Erik van Dijk, Louis Vermeulen, Daniël M. Miedema

Publikováno v: Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)

We recently introduced a method to derive intra-tumor heterogeneity (ITH) from a single copy number measurement. This method stratifies patients for survival and could potentially help to identify low and high-risk patients with clinical relevance.

Externí odkaz: https://doaj.org/article/6565d7e6ce88476081f21f138217e72c

Copy number heterogeneity identifies ER+ breast cancer patients that do not benefit from adjuvant endocrine therapy

Autor: Tom van den Bosch, Oscar M. Rueda, Carlos Caldas, Louis Vermeulen, Daniël M. Miedema

Publikováno v: British journal of cancer, 127(7), 1332-1339. Nature Publishing Group

Background: Endocrine therapy forms the backbone of adjuvant treatment for oestrogen-receptor-positive (ER+) breast cancer. However, it remains unclear whether adjuvant treatment improves survival rates in low-risk patients. Low intra-tumour heteroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d666583b6baf6ee099088af33ead11a
https://pure.amc.nl/en/publications/copy-number-heterogeneity-identifies-er-breast-cancer-patients-that-do-not-benefit-from-adjuvant-endocrine-therapy(8608236a-4bb3-4f3f-bc50-30d2e7a79164).html

Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer

Autor: Sophie C. Lodestijn, Khalid El Makrini, Tom van den Bosch, Daniël M. Miedema, Louis Vermeulen, Maria C. Lecca, Cynthia Waasdorp, Lisanne E. Nijman, Maarten F. Bijlsma, Saskia C. Belt, Kristiaan J. Lenos

Publikováno v: Cell reports, 37(3):109852. Cell Press
Cell Reports, Vol 37, Iss 3, Pp 109852-(2021)

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies. Effective treatment options are currently lacking, and targeted agents have so far demonstrated limited efficacy. It has been speculated that a rare population of can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21c6fc7b8bc97e10e675986807439d0
https://pure.amc.nl/en/publications/markerfree-lineage-tracing-reveals-an-environmentinstructed-clonogenic-hierarchy-in-pancreatic-cancer(195114a1-284e-4cd7-95f3-36856210ec0d).html

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Autor: Erik van Dijk, Jan Paul Medema, Bauke Ylstra, Daniël M. Miedema, Kristiaan J. Lenos, Veronique L. Veenstra, Lisanne E. Nijman, Maartje van der Heijden, Sanne M. van Neerven, Nina E. de Groot, Martin A. Nowak, Douglas J. Winton, Andrea Arricibita Varea, Bartlomiej Waclaw, Edward Morrissey, Maarten F. Bijlsma, Maria C. Lecca, Pramudita R. Prasetyanti, Sophie C. Lodestijn, Louis Vermeulen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 116(13), 6140-6145. National Academy of Sciences
van der Heijden, M, Miedema, D, Waclaw, B, Veenstra, V, Lecca, M, Nijman, L, Dijk, E, van Neerven, S, Lodestijn, S, Lenos, K, de Groot, N, Prasetyanti, P, Arricibita Varea, A, Winton, D, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M, Bijlsma, M & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
van der Heijden, M, Miedema, D M, Waclaw, B, Veenstra, V L, Lecca, M C, Nijman, L E, van Dijk, E, van Neerven, S M, Lodestijn, S C, Lenos, K J, de Groot, N E, Prasetyanti, P R, Varea, A A, Winton, D J, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M A, Bijlsma, M F & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116

Significance Colorectal cancer (CRC) is a heterogeneous disease, with significant variation in genotype and phenotype within each individual tumor. This intratumor heterogeneity emerges during tumor development due to clonal evolution and in part can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3067c66ea779680d543b2321a5015fc
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