Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐ l‐ Arabinofuranosidase Inhibitor

Autor: Daniël Linzel, Gideon J. Davies, Joan Coines, Shinya Fushinobu, Takatoshi Arakawa, Chihaya Yamada, Marta Artola, Akihiro Ishiwata, Nicholas McGregor, Gijsbert A. van der Marel, Herman S. Overkleeft, Satoko Amaki, Valentina Borlandelli, Yukishige Ito, Alba Nin-Hill, Carme Rovira, Jeroen D. C. Codée

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 60(11), 5754-5758. WILEY-V C H VERLAG GMBH

The recent discovery of zinc-dependent retaining glycoside hydrolases (GHs), with active sites built around a Zn(Cys)(3)(Glu) coordination complex, has presented unresolved mechanistic questions. In particular, the proposed mechanism, depending on a

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