The immunosuppressant FTY720 (Fingolimod) induces nuclear exit of the proto-oncogene SET/I2PP2A

Autor: Daniël Lam, B., Anthony, Eloise C., Hordijk, Peter L.

Publikováno v: Molecular and Cellular Pharmacology, 5(3), 95-107. Lumitext Publishing
Daniël Lam, B, Anthony, E C & Hordijk, P L 2013, ' The immunosuppressant FTY720 (Fingolimod) induces nuclear exit of the proto-oncogene SET/I2PP2A ', Molecular and Cellular Pharmacology, vol. 5, no. 3, pp. 95-107 . https://doi.org/10.4255/mcpharmacol.13.10

The proto-oncogene SET/I2PP2A, an inhibitor of the phosphatase PP2A and a potential therapeutic target for cancer, interacts with the RhoGTPase Rac1 and regulates cell motility. SET is primarily nuclear but can readily translocate to the cytoplasm. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::24530fb166ec99641dff86e243716f2c
https://research.vumc.nl/en/publications/ef99e3a9-650e-4ebd-9e34-e8a03e9f88a4