Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniël A. Lionarons"'
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1535-1542 (2012)
The apical Na+-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile s
Externí odkaz:
https://doaj.org/article/c9fa9b270f5043428af019f19cbb6abd
Autor:
Daniël A. Lionarons, Davide Zecchin, Jeffrey R. MacDonald, Wei-Li Di, Hui Chen, Miriam Molina, Stuart Horswell, Gemma Tell, Véronique Bataille, Dale Bryant, Julia Newton-Bishop, Philip Stanier, Gudrun E. Moore, Kiran Parmar, Josep Malvehy, Catherine A. Harwood, Satyamaanasa Polubothu, Cristina Carrera, Jérémie Nsengimana, Veronica A. Kinsler, Julian Downward, Nathan Wlodarchak, Alan Pittman, Susana Puig, Yongna Xing, Neil J. Sebire, Anna C. Thomas, Mark Harland, L. Al-Olabi, Mehdi Zarrei, Michael Howell, Sarah Brand, Paulina Stadnik, Stephen W. Scherer, Lilian Hunt, Eugene Healy, Dale Moulding, Paula Aguilera, J.A. Puig-Butillé, Deborah Morrogh, Vanessa Martins da Silva, Sam Loughlin, Regula Waelchli, Sara Martin Barberan, Greg Elgar, Lionel Larue
Publikováno v:
Genetics in medicine, 23(9), 1636-1647. Lippincott Williams and Wilkins
Genetics in Medicine
Genetics in Medicine
Purpose\ud Much of the heredity of melanoma remains unexplained. We sought predisposing germline copy-number variants using a rare disease approach.\ud \ud Methods\ud Whole-genome copy-number findings in patients with melanoma predisposition syndrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf020b972091ef0da9c25d686d2a0a5
https://pure.amc.nl/en/publications/inherited-duplications-of-ppp2r3b-predispose-to-nevi-and-melanoma-via-a-c21orf91driven-proliferative-phenotype(c7c1481a-d0e0-4090-8d51-8c03bd58e817).html
https://pure.amc.nl/en/publications/inherited-duplications-of-ppp2r3b-predispose-to-nevi-and-melanoma-via-a-c21orf91driven-proliferative-phenotype(c7c1481a-d0e0-4090-8d51-8c03bd58e817).html
Autor:
Michal Heger, Lindy K. Alles, Dirk R. de Waart, Megan J. Reiniers, Bulent Ergin, Adrie Maas, Thomas M. van Gulik, Pim B. Olthof, Steven W.M. Olde Damink, Frank G. Schaap, Joanne Verheij, Rowan F. van Golen, Lianne R. de Haan, Daniël A. Lionarons, Peter L.M. Jansen, Zehra Uz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific reports, 8(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 8:16529. Nature Publishing Group
Scientific reports, 8(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 8:16529. Nature Publishing Group
Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f8655a8dbd2aac3b05e4c83453dc90
http://link.springer.com/article/10.1038/s41598-018-33070-1
http://link.springer.com/article/10.1038/s41598-018-33070-1
Autor:
Gemma Tell, Michael Howell, L. Al-Olabi, Julia Newton-Bishop, Josep Malvehy, Susana Puig, Mark Harland, Lilian Hunt, Yongna Xing, Sam Loughlin, Jérémie Nsengimana, Gudrun E. Moore, Regula Waelchli, Lionel Larue, Veronica A. Kinsler, Wei-Li Di, Julian Downward, Anna C. Thomas, Dale Bryant, Catherine A. Harwood, Daniël A. Lionarons, Dale Moulding, Paula Aguilera, Satyamaanasa Polubothu, Greg Elgar, Sarah Brand, Eugene Healy, Cristina Carrera, Philip L. Beales, Paulina Stadnik, Davide Zecchin, Vanessa Martins da Silva, Mehdi Zarrei, Dagan Jenkins, Neil J. Sebire, Véronique Bataille, Stephen W. Scherer, Alan Pittman, Sara Martin Barberan, Juan-Anton Puig-Butillé, Deborah Morrogh, Nathan Wlodarchak, Philip Stanier, Miriam Molina, Jeffrey R. MacDonald, Stuart Horswell, Hui Chen, Kiran Parmar
The majority of the heredity of melanoma remains unexplained, however inherited copy number changes have not yet been systematically studied. The genetic environment is highly relevant to treatment stratification, and new gene discovery is therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09f513bc2b8b1d8046d1663a4b98ebd
https://doi.org/10.1101/672576
https://doi.org/10.1101/672576
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology, 312(4), R477-R484. American Physiological Society
The Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) is a hepatocyte-specific solute carrier, which plays an important role in maintaining bile salt homeostasis in mammals. The absence of a hepatic Na+-dependent bile salt transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998c70c0f1592fe4c613f6261a9f96c5
https://europepmc.org/articles/PMC5407083/
https://europepmc.org/articles/PMC5407083/
Autor:
Ralph Fritsch, Miguel M. Murillo, Sareena Rana, David C. Hancock, Christopher I. Moore, Ian Rosewell, Eleanor Herbert, Dinis Pedro Calado, Joana Carvalho, Bradley Spencer-Dene, Philip East, Richard R. Neubig, Gordon Stamp, Djamil Damry, Daniël A. Lionarons, Miriam Molina-Arcas, Julian Downward
Publikováno v:
Cancer Cell
Cancer cell, 36(1), 68-83.e9. Cell Press
Cancer cell, 36(1), 68-83.e9. Cell Press
Summary RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1P29S in melanoma development and reveal that RAC1P29S activates PAK, AKT, and a gene expression progra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c66c04112d457e7f5d2d275d4630be
https://doi.org/10.1016/j.ccell.2019.05.015
https://doi.org/10.1016/j.ccell.2019.05.015
Autor:
Coen C. Paulusma, Henny Rusch, Lindy K. Alles, Hendrik A. Marsman, Thomas M. van Gulik, Vincent A. van der Mark, Rowan F. van Golen, Joanne Verheij, Jaap J. Kloek, Daniël A. Lionarons, Dirk R. de Waart, Michal Heger, Ulrich Beuers
Publikováno v:
Scientific Reports
Scientific reports, 6. Nature Publishing Group
Scientific reports, 6. Nature Publishing Group
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. It is uncertain if simple steatosis, the initial and prevailing form of NAFLD, sensitizes the liver to cholestasis. Here, we compared the effects of obstructive chole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4070a4feb01538cffc3ba96840eff3a1
https://pubmed.ncbi.nlm.nih.gov/27535001
https://pubmed.ncbi.nlm.nih.gov/27535001
Autor:
Shi-Ying Cai, Lee R. Hagey, Daniël A. Lionarons, James L. Boyer, Albert Mennone, Carol J. Soroka
Publikováno v:
Hepatology, 57(6). John Wiley and Sons Ltd
The sea lamprey (Petromyzon marinus) is a genetically programmed animal model for biliary atresia, as it loses its bile ducts and gallbladder during metamorphosis. However, in contrast to patients with biliary atresia or other forms of cholestasis wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a533e9820e5f6d15ff40f3c571cd366c
https://pure.amc.nl/en/publications/adult-sea-lamprey-tolerates-biliary-atresia-by-altering-bile-salt-composition-and-renal-excretion(ba8d1521-234f-4228-80c3-897ab815f135).html
https://pure.amc.nl/en/publications/adult-sea-lamprey-tolerates-biliary-atresia-by-altering-bile-salt-composition-and-renal-excretion(ba8d1521-234f-4228-80c3-897ab815f135).html
Autor:
Thomas M. van Gulik, Michal Heger, Ulrich Beuers, Dirk R. de Waart, Daniël A. Lionarons, Hendrik A. Marsman, Coen C. Paulusma, Jaap J. Kloek, Joanne Verheij
Publikováno v:
Gastroenterology. 144:S-1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6470585a014c32966948a0f2137cf717
https://doi.org/10.1016/s0016-5085(13)63784-1
https://doi.org/10.1016/s0016-5085(13)63784-1