Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Danièle Schaer"'
Autor:
Solange Kharoubi-Hess, Sophie Roy, Käthi Geering, Stéphanie Bibert, Jean-Daniel Horisberger, David Aebischer, Florian Desgranges, Danièle Schaer
Publikováno v:
Molecular Biology of the Cell. 20:1132-1140
FXYD3 (Mat-8) proteins are regulators of Na,K-ATPase. In normal tissue, FXYD3 is mainly expressed in stomach and colon, but it is also overexpressed in cancer cells, suggesting a role in tumorogenesis. We show that FXYD3 silencing has no effect on ce
Autor:
Tatiana V. Korneenko, Rossen Radkov, Danièle Schaer, Nikolai N. Modyanov, Stéphanie Bibert, Nikolay B. Pestov, Nisar Ahmad, Käthi Geering, Hao Zhao, Sophie Roy
Publikováno v:
Proceedings of the National Academy of Sciences. 104:11215-11220
Change in gene functions (gene cooption) is one of the key mechanisms of molecular evolution. Genes can acquire new functions via alteration in properties of encoded proteins and/or via changes in temporal or spatial regulation of expression. Here we
Autor:
Rossen Radkov, Solange Kharoubi-Hess, Danièle Schaer, Käthi Geering, Jean-Daniel Horisberger, Nikolai N. Modyanov
Publikováno v:
Biochemical and Biophysical Research Communications, vol. 356, no. 1, pp. 142-6
Cardiac steroids inhibit Na,K-ATPase and the related non-gastric H,K-ATPase, while they do not interact with gastric H,K-ATPase. Introducing an arginine, the residue present in the gastric H,K-ATPase, in the second extracellular loop at the correspon
Publikováno v:
Journal of Biological Chemistry. 281:39142-39151
Six of 7 FXYD proteins have been shown to be tissue-specific modulators of Na,K-ATPase. In this study, we have identified two splice variants of human FXYD3, or Mat-8, in CaCo-2 cells. Short human FXYD3 has 72% sequence identity with mouse FXYD3, whe
Role of the Transmembrane Domain of FXYD7 in Structural and Functional Interactions with Na,K-ATPase
Publikováno v:
Journal of Biological Chemistry. 280:42738-42743
Members of the FXYD family are tissue-specific regulators of the Na,K-ATPase. Here, we have investigated the contribution of amino acids in the transmembrane (TM) domain of FXYD7 to the interaction with Na,K-ATPase. Twenty amino acids of the TM domai
Publikováno v:
The Journal of Cell Biology
Subunit assembly plays an essential role in the maturation of oligomeric proteins. In this study, we have characterized the main structural and functional consequences of the assembly of alpha and beta subunits of Na,K-ATPase. Xenopus oocytes injecte
Publikováno v:
The Journal of biological chemistry. 283(1)
Phospholemman (FXYD1), mainly expressed in heart and skeletal muscle, is a member of the FXYD protein family, which has been shown to decrease the apparent K(+) and Na(+) affinity of Na,K-ATPase ( Crambert, G., Fuzesi, M., Garty, H., Karlish, S., and
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (10), pp.7450-6. ⟨10.1074/jbc.M609872200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (10), pp.7450-6. ⟨10.1074/jbc.M609872200⟩
International audience; The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endolymph ionic composition and the endocochlear potential. A key protein in the maintenance of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b429f64b87fae35a1e6a445999cd4c73
https://www.hal.inserm.fr/inserm-00173536/document
https://www.hal.inserm.fr/inserm-00173536/document
Publikováno v:
Molecular pharmacology. 65(2)
Inhibition of Na,K-ATPase alpha2 isoforms in the human heart is supposed to be involved in the inotropic effect of cardiac glycosides, whereas inhibition of alpha1 isoforms may be responsible for their toxic effects. Human Na,K-ATPase alpha1 and alph