Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Danièle, Demarquay"'
Autor:
Gregoire Prevost, Pierre Roubert, Daniel W. Zaharevitz, Marie Odile Lonchampt, Samir Attoub, Sophie Chaumeron, Mike Alley, Erik Bruyneel, Hélène Coulomb, Ann Savola, Philip G. Kasprzyk, Susan Holbeck, John Wright, Quang-Dé Nguyen, Patricia Forgez, Christian Gespach, Marie C. Brezak, Mark Bracke, Eric Ferrandis, Marion Huchet, Danièle Demarquay
Publikováno v:
Cancer Research. 66:9227-9234
A large number of hormones and local agonists activating guanine-binding protein-coupled receptors (GPCR) play a major role in cancer progression. Here, we characterize the new imidazo-pyrazine derivative BIM-46174, which acts as a selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e35e09855de720491c38a3f5fd371a5
https://doi.org/10.1158/0008-5472.can-05-4205
https://doi.org/10.1158/0008-5472.can-05-4205
Autor:
Dennis Bigg, José Camara, Laurence Lesueur-Ginot, Hélène Coulomb, Philip G. Kasprzyk, Danièle Demarquay, Marion Huchet, Olivier Lavergne, Gregoire Prevost
Publikováno v:
Cancer Research. 64:4942-4949
BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered β-hydroxylactone ring. Preclinical data reported here show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503adab5a27c3987410b3a0e91a21700
https://doi.org/10.1158/0008-5472.can-03-3872
https://doi.org/10.1158/0008-5472.can-03-3872
Autor:
José Camara, Laurence Lesueur-Ginot, Christian Bailly, Hélène Coulomb, Marion Huchet, Danièle Demarquay, Dennis Bigg, Olivier Lavergne, Philip G. Kasprzyk
Publikováno v:
Anti-Cancer Drugs. 12:9-19
BN 80915, a lead compound of the homocamptothecin (hCPT) family, has entered clinical trials. BN 80915 is a difluoro-hCPT where the six-membered a-hydroxylactone ring of camptothecin (CPT) is replaced by a seven-membered b-hydroxylactone ring. Precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a91118914428641bbd02e097e292545
https://doi.org/10.1097/00001813-200101000-00003
https://doi.org/10.1097/00001813-200101000-00003
Autor:
Olivier Lavergne, Alain Rolland, Christophe Lanco, Laurence Lesueur-Ginot, Marion Huchet, Dennis Bigg, Danièle Demarquay, Hélène Coulomb, Jeremiah Harnett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2599-2602
BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509d0222579727f64bca61d8645c5fc3
https://doi.org/10.1016/s0960-894x(99)00428-x
https://doi.org/10.1016/s0960-894x(99)00428-x
Autor:
Alain Rolland, Christophe Lanco, Olivier Lavergne, Marion Huchet, Hélène Coulomb, Dennis Bigg, Laurence Lesueur-Ginot, Danièle Demarquay, Jeremiah Harnett
Publikováno v:
ChemInform. 30
BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ac45dad2ceaf2e3351f53a6082eae9
https://doi.org/10.1002/chin.199949194
https://doi.org/10.1002/chin.199949194
Autor:
Grégoire P, Prévost, Marie O, Lonchampt, Susan, Holbeck, Samir, Attoub, Daniel, Zaharevitz, Mike, Alley, John, Wright, Marie C, Brezak, Hélène, Coulomb, Ann, Savola, Marion, Huchet, Sophie, Chaumeron, Quang-Dé, Nguyen, Patricia, Forgez, Erik, Bruyneel, Mark, Bracke, Eric, Ferrandis, Pierre, Roubert, Danièle, Demarquay, Christian, Gespach, Philip G, Kasprzyk
Publikováno v:
Cancer research. 66(18)
A large number of hormones and local agonists activating guanine-binding protein-coupled receptors (GPCR) play a major role in cancer progression. Here, we characterize the new imidazo-pyrazine derivative BIM-46174, which acts as a selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0d5e541f3696ee2548f42b26dff91bb
https://pubmed.ncbi.nlm.nih.gov/16982767
https://pubmed.ncbi.nlm.nih.gov/16982767
Autor:
Danièle, Demarquay, Marion, Huchet, Helène, Coulomb, Laurence, Lesueur-Ginot, Olivier, Lavergne, José, Camara, Philip G, Kasprzyk, Grégoire, Prévost, Dennis C H, Bigg
Publikováno v:
Cancer research. 64(14)
BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62a098ada186a8b6157c1bdda2bf5c07
https://pubmed.ncbi.nlm.nih.gov/15256467
https://pubmed.ncbi.nlm.nih.gov/15256467
Autor:
José Camara, Laurence Lesueur-Ginot, Marion Huchet, Danièle Demarquay, Hélène Coulomb, Dennis Bigg, Olivier Lavergne
Publikováno v:
Europe PubMed Central
Homocamptothecins (hCPTs, FIG. 1) represent a new family of camptothecin (CPT) analogues in which insertion of a methylene (-CH2-) spacer between the alcohol moiety and carbonyl group of the classical six-membered α-hydroxylactone ring results in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8ee3be736fea4e21005f66365feb3d
https://pubmed.ncbi.nlm.nih.gov/11193906
https://pubmed.ncbi.nlm.nih.gov/11193906
Autor:
Manginot Eric, Olivier Lavergne, D. C. H. Bigg, N. Baroggi, Marion Huchet, N. Muller, Hélène Coulomb, C. Lanco, J.-B. Cazaux, Christian Bailly, J. Camara, Danièle Demarquay, A. Rolland, C. Le Breton
Publikováno v:
Journal of medicinal chemistry. 43(11)
Homocamptothecin (hCPT) is an E-ring modified camptothecin (CPT) analogue bearing a methylene spacer between the alcohol and carboxyl functions of the CPT lactone. Combining pronounced inhibitory activity of topoisomerase I (Topo I) with enhanced pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9b03698c12b6848b3c3e6b7d92c2c5
https://pubmed.ncbi.nlm.nih.gov/10841808
https://pubmed.ncbi.nlm.nih.gov/10841808
Autor:
D. C. H. Bigg, Marion Huchet, Laurent Dassonneville, Hélène Coulomb, Olivier Lavergne, Danièle Demarquay, Christian Bailly, Amélie Lansiaux
Publikováno v:
Biochemistry. 38(47)
Homocamptothecin (hCPT) contains a seven-membered beta-hydroxylactone in place of the conventional six-membered alpha-hydroxylactone ring found in camptothecin and its tumor active analogues, including topotecan and irinotecan. The homologation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407a961414cc0ed6da245950fd9851be
https://pubmed.ncbi.nlm.nih.gov/10569939
https://pubmed.ncbi.nlm.nih.gov/10569939