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pro vyhledávání: '"Danhua Zheng"'
Autor:
Huiqun Dong, Jia You, Yu Zhao, Danhua Zheng, Yi Zhong, Gaozheng Li, Zuquan Weng, Heng Luo, Shan Jiang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background and Aim: More than half of the small-molecule kinase inhibitors (KIs) induced liver injury clinically. Meanwhile, studies have shown a close relationship between mitochondrial damage and drug-induced liver injury (DILI). We aimed to study
Externí odkaz:
https://doaj.org/article/3ca35110cc5641349826759a9e9959f9
Publikováno v:
BioMed Research International, Vol 2020 (2020)
BioMed Research International
BioMed Research International
Drug discovery is a costly process which usually takes more than 10 years and billions of dollars for one successful drug to enter the market. Despite all the safety tests, drugs may still cause adverse reactions and be restricted in use or even with
BACKGROUND Preventing Drug-induced liver injury (DILI) in advance is an important task to improve drug safety and protect patient health. It was reported that more than half of small-molecule kinase inhibitors (KIs) induced DILI clinically. Meanwhile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a515c2492b5f92a377d4e254f1fd424
https://doi.org/10.2196/preprints.33257
https://doi.org/10.2196/preprints.33257
Publikováno v:
Biochemical and Biophysical Research Communications. 386:739-743
Telomerase is almost universally required for cellular immortality and is permissive for tumorigenesis. Accumulating evidence suggests that telomerase may have roles in cellular processes independent of its role in telomere maintenance. However, the
Publikováno v:
Journal of cellular biochemistry. 105(5)
Telomerase is reactivated in over 90% of tumors and plays critical roles in tumor progression. The mechanisms by which telomerase is up-regulated in cancer cells are poorly understood. Here we showed that a bioactive lipid, lysophophatidic acid (LPA)