Zobrazeno 1 - 10
of 1 730
pro vyhledávání: '"Danhof, M."'
Publikováno v:
In Drug Discovery Today: Technologies September 2013 10(3):e373-e383
Autor:
Ackaert, O.W., De Graan, J., Capancioni, R., Della Pasqua, O.E., Dijkstra, D., Westerink, B.H., Danhof, M., Bouwstra, J.A.
Publikováno v:
In Journal of Controlled Release 2010 144(3):296-305
Publikováno v:
The AAPS Journal. 19:1249-1252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502eb762492f5ca3d7c68f9b3178d61d
https://doi.org/10.1208/s12248-017-0080-x
https://doi.org/10.1208/s12248-017-0080-x
Autor:
Wite, W.E.A. de, Versfelt, J.W., Kuzikov, M., Rolland, S., Georgi, V., Gribbon, P., Gul, S., Huntjens, D., Graaf, P.H. van der, Danhof, M., Fernández-Montalván, A., Witt, G., Lange, E.C.M. de
Publikováno v:
British Journal of Pharmacology, 175(21), 4121-4136
Background and Purpose: Target binding kinetics influence the time course of the drug effect (pharmacodynamics) both (i) directly, by affecting the time course of target occupancy, driven by the pharmacokinetics of the drug, competition with endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1dda80f5c4cea245e53f69f5c0b80679
https://doi.org/10.1111/bph.14456
https://doi.org/10.1111/bph.14456
Autor:
Witte, W.E.A. de, Rottschäfer, V., Danhof, M., Graaf, P.H. van der, Peletier, L.A., Lange, E.C.M. de
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics, 45(5), 763
The original version of this article was published open access. Unfortunately, due to a technical issue, the copyright holder name in the online version (HTML and XML) is incorrectly published as "Springer Science+Business Media, LLC, part of Springe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28926dc8d69bc7c3b3bb77e0d4a72a7
https://doi.org/10.1007/s10928-018-9604-y
https://doi.org/10.1007/s10928-018-9604-y
Autor:
Calvier, E.A.M., Krekels, E.H.J., Yu, H., Välitalo, P.A.J., Johnson, T.N., Rostami-Hodjegan, A., Tibboel, D., Graaf, P.H. van der, Danhof, M., Knibbe, C.A.J.
Publikováno v:
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(3), 175-185
CPT: Pharmacometrics & Systems Pharmacology, 7(3), 175-185. Wiley-Blackwell
Calvier, E AM, Krekels, E HJ, Yu, H, Valitalo, P AJ, Johnson, T N, Rostami-Hodjegan, A, Tibboel, D, van der Graaf, P H, Danhof, M & Knibbe, C AJ 2018, ' Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments ', CPT: Pharmacometrics and Systems Pharmacology, vol. 7, no. 3, PSP412273, pp. 175-185 . https://doi.org/10.1002/psp4.12273
CPT: Pharmacometrics & Systems Pharmacology, 7(3), 175-185. Wiley-Blackwell
Calvier, E AM, Krekels, E HJ, Yu, H, Valitalo, P AJ, Johnson, T N, Rostami-Hodjegan, A, Tibboel, D, van der Graaf, P H, Danhof, M & Knibbe, C AJ 2018, ' Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments ', CPT: Pharmacometrics and Systems Pharmacology, vol. 7, no. 3, PSP412273, pp. 175-185 . https://doi.org/10.1002/psp4.12273
For scaling drug plasma clearance (CLp) from adults to children, extrapolations of population pharmacokinetic (PopPK) covariate models between drugs sharing an elimination pathway have enabled accelerated development of pediatric models and dosing re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ff64263ceda4fc73c4283b82caa166c
https://doi.org/10.1002/psp4.12273
https://doi.org/10.1002/psp4.12273
Autor:
Yamamoto, Y., Valitalo, P.A.J., Huntjens, D.R., Proost, J.H., Vermeulen, A., Krauwinkel, W., Beukers, M.W., Berg, D.J. van den, Hartman, R.J., Wong, Y.C., Danhof, M., Hasselt, J.G.C. van, Lange, E.C.M. de
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, 6(11), 765–777
Drug development targeting the central nervous system (CNS) is challenging due to poor predictability of drug concentrations in various CNS compartments. We developed a generic physiologically based pharmacokinetic (PBPK) model for prediction of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::10a828f8ed78f3ffab87d95756e51463
https://hdl.handle.net/1887/59075
https://hdl.handle.net/1887/59075
Autor:
Duong, Janna, de Winter, W, Choy, S, Plock, N, Naik, H, Krauwinkel, W, Visser, SAG, Verhamme, Katia, Sturkenboom, MCJM, Stricker, Bruno, Danhof, M
Publikováno v:
British Journal of Clinical Pharmacology, 83(3), 487-497. Wiley-Blackwell Publishing Ltd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::2191a258b194a6326128a4c5e1a3e9b9
https://pure.eur.nl/en/publications/9e5a8f7c-7758-4a06-a0c5-c41caf353421
https://pure.eur.nl/en/publications/9e5a8f7c-7758-4a06-a0c5-c41caf353421
Autor:
Musuamba, F.T., Teutonico, D., Maas, H.J., Facius, A., Yang, S., Danhof, M., Della Pasqua, O.
Publikováno v:
Pharmaceutical Research
Purpose Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::adfe76735eaa2d04e84f73ea9362d201
http://europepmc.org/articles/PMC4300418
http://europepmc.org/articles/PMC4300418
Publikováno v:
Cephalalgia. Jul2009, Vol. 29 Issue 7, p772-780. 9p. 1 Diagram, 3 Charts, 3 Graphs.