Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dange Vijay Kumar"'
Autor:
Huiyong Hu, Barry Patrick Hart, Roopa Rai, Michael J. Green, Ravi Rajagopalan, Yu M. Xia, Joseph D. Ho, John R. Somoza, Isabelle Lehoux, Dange Vijay Kumar, Jennifer Riggs, Ken A. Brameld, James W. Janc, Tony Ton, Wendy B. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:300-304
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3593c853fb618014eb009af3250b00b8
https://doi.org/10.1016/j.bmcl.2011.11.013
https://doi.org/10.1016/j.bmcl.2011.11.013
Autor:
Rena McKinnon, In Chul Kim, Vijay Baichwal, Harry Austin, Esther Arranz-Plaza, Kraig M. Yager, David Gerrish, Dange Vijay Kumar, Mark B. Anderson, Jennifer E. Garrus, Robert O. Carlson, Michael Saunders
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6377-6380
Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cdc69898aa6a2bf095e6e1f80061f1
https://doi.org/10.1016/j.bmcl.2008.10.098
https://doi.org/10.1016/j.bmcl.2008.10.098
Autor:
Huiyong Hu, Tony Ton, Dange Vijay Kumar, Roopa Rai, Michael J. Green, Isabelle Lehoux, Ravi Rajagopalan, Ken A. Brameld, John R. Somoza, Michael B. Shaghafi, James W. Janc, Nhat To, Yu M. Xia, Wendy B. Young
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Hepatitis C virus (HCV) infection is treated with a combination of peginterferon alfa-2a/b and ribavirin. To address the limitations of this therapy, numerous small molecule agents are in development, which act by directly affecting key steps in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270e14ccf3b91a31d99f784e601b38bf
https://pubmed.ncbi.nlm.nih.gov/21145235
https://pubmed.ncbi.nlm.nih.gov/21145235