Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Danette Pascarella"'
Autor:
Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf
https://eprints.gla.ac.uk/146530/1/146530.pdf
Autor:
Cyrille Sur, Danette Pascarella, Constantine Kreatsoulas, Marlene A. Jacobson, Julie A. O'Brien
Publikováno v:
Molecular Pharmacology. 78:648-657
Activation of M1 muscarinic receptors occurs through orthosteric and allosteric binding sites. To identify critical residues, site-directed mutagenesis and chimeric receptors were evaluated in functional calcium mobilization assays to compare orthost
Autor:
Marlene A. Jacobson, P. Jeffrey Conn, Douglas J. Pettibone, Cyrille Sur, Jacinta B. Williams, Danette Pascarella, Marion Wittmann, Philip E. Brandish, Edward M. Scolnick, Pierre Mallorga
Publikováno v:
Proceedings of the National Academy of Sciences. 100:13674-13679
The molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia remain elusive. The interaction of clozapine with many G protein-coupled receptors is well documented but less is known a
Autor:
Pierre Mallorga, Douglas J. Pettibone, E V Lis, Marlene A. Jacobson, Michael Leviten, J. Fred Hess, Melissa A. Snyder, Patricia J. Hey, Danette Pascarella, Jacinta B. Williams, Zhizhen Zeng
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:305-313
Mice deficient in the neurotensin (NT)-1 receptor (NTR1) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT. F2 generation (C57BL6/Sv129J) NTR1 knockout (-/-) mice were viable, and showed normal growt
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Autor:
Denise J. Bickel, Lone Veng, Marlene A. Jacobson, William J. Ray, K. H. Jones, Cyrille Sur, Danette Pascarella, Marion Wittmann, Rose Flick, Michelle Pearson, Constantine Kreatsoulas, Paul J. Shughrue, Scott M. Doran, Craig W. Lindsley, Gene G. Kinney, Matthew A. Seager, Guy R. Seabrook, Alexander McCampbell, Maryann Burno, William D. Shipe, Valerie Kuzmick Graufelds, Andrew Danziger, Lei Ma, Christopher P. Regan, Scott D. Kuduk, Guangping Xu, Susan L. Garson, Renee C. Gaspar
The forebrain cholinergic system promotes higher brain function in part by signaling through the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d52a829eb7f4a1dfa08990154309a
https://europepmc.org/articles/PMC2732705/
https://europepmc.org/articles/PMC2732705/
Autor:
Nathan O. Surles, Nancy A. Sachs, Jason M. Uslaner, Tim Sparey, Monika Kandebo, Mary Beth Young, Richard M. Hinchliffe, Caitlyn H. McNaughton, Brian A. Jones, Shankar Venkatraman, Marlene A. Jacobson, Peter H. Hutson, Lihang Yao, Sean M. Smith, Sarah L. Huszar, Danette Pascarella, Nicholas J. Brandon, Chadwick M. Mullins
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 328(3)
Multiple studies indicate that N-methyl-D-aspartate (NMDA) receptor hypofunction underlies some of the deficits associated with schizophrenia. One approach for improving NMDA receptor function is to enhance occupancy of the glycine modulatory site on
Autor:
Marlene A. Jacobson, Shankar Venkatraman, Pete H. Hutson, Nicholas J. Brandon, G. Sridhar Prasad, Pravien Abeywickrema, V V Sardana, Sanjeev Munshi, Melanie Zea Sakatis, Danette Pascarella, Noel Byrne, Alister Campbell, Sarah Almond, Tim Sparey, Nancy A. Sachs, Brian A. Jones, Mary Beth Young, Andrew Pike
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid
Autor:
Denise J. Bickel, Gene G. Kinney, Matthew A. Seager, Adam J. Simon, Marlene A. Jacobson, Keith Jones, Lone Veng, William J. Ray, Craig W. Lindsley, Valerie Kuzmick Graufields, Scott D. Kuduk, William D. Shipe, Guy R. Seabrook, Guoxin Wu, Marion Wittmann, Lei Ma, Maryann Burno, Diane Posavec, Krista Getty, Jacquelynn J. Cook, Danette Pascarella, Cyrille Sur, Ming-Chih Crouthamel, Sethu Sankaranarayananan, Michael W. Marlatt
Publikováno v:
Alzheimer's & Dementia. 4:T761-T761