Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Danelle Eto"'
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Akademický článek
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
Autor: Danelle Eto, Christopher Lao, Daniel DiToro, Burton Barnett, Tania C Escobar, Robin Kageyama, Isharat Yusuf, Shane Crotty
Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17739 (2011)
Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation, and directly act on B cells. Here we investigated the absence of IL-6 alone, IL-21 alone, or
Externí odkaz: https://doaj.org/article/f2e640a8f19c40a2ab24380f4d2b1dfb
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3
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells
Autor: Yun-Cai Liu, Guiying Peng, Danelle Eto, Nengming Xiao, Chris Elly, Shane Crotty
Publikováno v: Nature Immunology. 15:657-666
Follicular helper T cells (T(FH) cells) are responsible for effective B cell-mediated immunity, and Bcl-6 is a central factor for the differentiation of T(FH) cells. However, the molecular mechanisms that regulate the induction of T(FH) cells remain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b9a189d11b3144fb4532982be889fc
https://doi.org/10.1038/ni.2912
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4
Cutting Edge: STAT1 Is Required for IL-6–Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation
Autor: Jessica A. Yang, Christopher Lao, Shane Crotty, Youn Soo Choi, Danelle Eto
Publikováno v: The Journal of Immunology. 190:3049-3053
Bcl6 is required for CD4 T cell differentiation into T follicular helper cells (Tfh). In this study, we examined the role of IL-6 in early processes of in vivo Tfh differentiation, because the timing and mechanism of action of IL-6 in Tfh differentia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a66cab284212c8171e44a1740736737
https://doi.org/10.4049/jimmunol.1203032
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5
Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation
Autor: Mark A. Kroenke, Michael Cho, Michela Locci, Terence M. Davidson, Danelle Eto, Shane Crotty, Elias K. Haddad
Publikováno v: The Journal of Immunology. 188:3734-3744
Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for the generation of high-affinity Abs and immunological memory and, therefore, are critical for the protective immunity elicited by most human vaccines. Transcripti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989c929c62426a099a42132e6bcb2814
https://doi.org/10.4049/jimmunol.1103246
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6
ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6
Autor: Danelle Eto, Tania C. Escobar, Robert J. Johnston, Christopher Lao, Laurel A. Monticelli, Robin Kageyama, Shane Crotty, Youn Soo Choi
Publikováno v: Immunity. 34(6):932-946
Summary The nature of follicular helper CD4 + T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation and the time at which Tfh cell differentiation occurs. Here we determine that Tfh ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59151c1d2c04857f10a04227f939c92a
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7
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
Autor: Tania C. Escobar, Christopher Lao, Danelle Eto, Isharat Yusuf, Burton E. Barnett, Robin Kageyama, Shane Crotty, Daniel DiToro
Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 3, p e17739 (2011)
Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation, and directly act on B cells. Here we investigated the absence of IL-6 alone, IL-21 alone, or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ae0eb96b3b731b732a3c455db58855
http://europepmc.org/articles/PMC3056724
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8
In vivo regulation of Bcl6 and T follicular helper cell development
Autor: Danelle Eto, Kyle Hansen, Joe Craft, Anmol Chandele, Xuemei Dong, Sairy Hernandez, Alexander L. Dent, Shane Crotty, Amanda C. Poholek, Susan M. Kaech, Jason S. Weinstein, Jared M. Odegard
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 185(1)
Follicular helper T (TFH) cells, defined by expression of the surface markers CXCR5 and programmed death receptor-1 (PD-1) and synthesis of IL-21, require upregulation of the transcriptional repressor Bcl6 for their development and function in B cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d70ac2a64c1ac31d6afec87d6b710e7
https://pubmed.ncbi.nlm.nih.gov/20519643
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9
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
Autor: Alexander L. Dent, Daniel DiToro, Robert J. Johnston, Isharat Yusuf, Joe Craft, Burton E. Barnett, Danelle Eto, Amanda C. Poholek, Shane Crotty
Publikováno v: Science (New York, N.Y.). 325(5943)
T Follicular Helper Cell Differentiation When B cells respond to an infection, they often require help from CD4 + T cells to mount a proper response. It is thought that a subset of CD4 + effector T cells, called T follicular helper cells (T FH ), per
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef492590045741dc0e1510896d1d081
https://pubmed.ncbi.nlm.nih.gov/19696339
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