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pro vyhledávání: '"Daneli Lopez-Perez"'
Autor:
Sucharita Bose, C. Nicklaus Steussy, Daneli López-Pérez, Tim Schmidt, Samadhi C. Kulathunga, Mohamed N. Seleem, Mark Lipton, Andrew D. Mesecar, Victor W. Rodwell, Cynthia V. Stauffacher
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
High-throughput in vitro screening and crystal structures identify a non-statin inhibitor of HMG-CoA reductase for novel antibacterial drug design.
Externí odkaz:
https://doaj.org/article/ff33f7666d8d44099aa084b1ad4f545f
Publikováno v:
AMB Express
Manual and automated methods were compared for routine screening of compounds for antimicrobial activity. Automation generally accelerated assays and required less user intervention while producing comparable results. Automated protocols were validat
Publikováno v:
Chemical Biology & Drug Design. 79:260-269
Two molecular scaffolds were designed using the CAVEAT molecular design package to inhibit the oligomerization of protective antigen (PA63), a key protein component of anthrax toxin. The inhibitors were designed to prevent heptamerization of PA63 by