Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dane Van Domelen"'
Autor:
Darrell White, Muhamed Baljevic, Gary Schiller, Suzanne Lentzsch, Evgeni Chubar, Noa Lavi, Dane Van Domelen, Ohad Bentur, Sumit Madan
Publikováno v:
HemaSphere, Vol 7, p e899038f (2023)
Externí odkaz:
https://doaj.org/article/b8ad9ccb9a8741008a6b591a95cc73d4
Publikováno v:
HemaSphere, Vol 7, p e24332f1 (2023)
Externí odkaz:
https://doaj.org/article/d1313f1f10f24e5e99171b261463c886
Autor:
Cristina Gasparetto, Suzanne Lentzsch, Gary Schiller, Natalie Callander, Sascha Tuchman, Christine Chen, Darrell White, Rami Kotb, Heather Sutherland, Michael Sebag, Muhamed Baljevic, William Bensinger, Richard LeBlanc, Chris Venner, Nizar Bahlis, Adriana Rossi, Noa Biran, Heidi Sheehan, Jean‐Richard Saint‐Martin, Dane Van Domelen, Kazuharu Kai, Jatin Shah, Sharon Shacham, Michael Kauffman, Brea Lipe
Publikováno v:
eJHaem, Vol 2, Iss 1, Pp 56-65 (2021)
Abstract We assessed the safety, efficacy, maximum tolerated dose (MTD), and the recommended phase 2 dose (RP2D) of selinexor, a first in class oral selective inhibitor of nuclear export (100 mg once weekly [QW] or 60 mg twice weekly), in combination
Externí odkaz:
https://doaj.org/article/69e08a3b96d24bf1a3690cc152ca6a6b
Autor:
Brea Lipe, Sascha A. Tuchman, Noa Biran, Michael Sebag, Jatin J. Shah, Sumit Madan, Michael Kauffman, Heather J. Sutherland, William I. Bensinger, Nizar J. Bahlis, Jorge Monge, Ohad S. Bentur, Rami Kotb, Cristina Gasparetto, Richard Leblanc, Muhamed Baljevic, Christopher P. Venner, Darrell White, Gary J. Schiller, Andrew DeCastro, Dane Van Domelen, Chris Zhiyi Zhang, Natalie S. Callander, Suzanne Lentzsch, Sharon Shacham, Christine Chen
Publikováno v:
eJHaem. 3:1270-1276
Background Multiple myeloma (MM) is considered an incurable hematologic malignancy despite a plethora of standard and novel agents. There is no consensus on the optimal sequencing of available therapies in relapsed/refractory MM (RRMM), even in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f0c9b7649a2245a2c47b66758fd533
https://doi.org/10.1002/jha2.572
https://doi.org/10.1002/jha2.572
Autor:
Praneeth Reddy Sudalagunta, Rafael Canevarolo, Mark Meads, Ariosto Silva, Xiaohong zhao, Christopher Cubitt, Gabriel DeAvila, Raghunandan Reddy Alugubelli, Constantine Logothetis, Alexandre Tungesvik, Qi Zhang, Oliver Hampton, Jamie Teer, Eric Welsh, Sean Yoder, Bijal Shah, Lori Hazlehurst, Robert Gatenby, Dane Van Domelen, Yi Chai, Feng Wang, Andrew DeCastro, Amanda Bloomer, Erin Seigel, Daniel Sullivan, Melissa Alsina, Taiga Nishihori, Jason Brayer, John L. Cleveland, William Dalton, Robert Gillies, Christopher Walker, Yosef Landesman, Rachid Baz, Ariosto Siqueira Silva, Kenneth Shain
We present a unique database of tumor samples from 399 multiple myeloma (MM) patients, whose functional genomic landscape was assessed by integrating ex vivo drug sensitivity to 138 drugs, clinical variables, cytogenetics, mutational profiles and tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5572d3585db54b135e0ec4d00f6401
https://doi.org/10.21203/rs.3.rs-1723993/v1
https://doi.org/10.21203/rs.3.rs-1723993/v1
Autor:
Brea Lipe, Kazuharu Kai, Muhamed Baljevic, Rami Kotb, Suzanne Lentzsch, Cristina Gasparetto, Chris Venner, Nizar J. Bahlis, Natalie S. Callander, Jatin P. Shah, Heather J. Sutherland, Noa Biran, Dane Van Domelen, Darrell White, Jean-Richard Saint-Martin, Gary J. Schiller, Michael Sebag, Sharon Shacham, Richard Leblanc, Adriana C Rossi, William I. Bensinger, Sascha A. Tuchman, Michael Kauffman, Heidi Sheehan, Christine Chen
Publikováno v:
eJHaem. 2:56-65
We assessed the safety, efficacy, maximum tolerated dose (MTD), and the recommended phase 2 dose (RP2D) of selinexor, a first in class oral selective inhibitor of nuclear export (100 mg once weekly [QW] or 60 mg twice weekly), in combination with dar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fe77a82ee00049795efdb680fe1411
https://doi.org/10.1002/jha2.122
https://doi.org/10.1002/jha2.122
Autor:
William I. Bensinger, Nizar J. Bahlis, Jatin P. Shah, Heather J. Sutherland, Sonia Ammu, Cristina Gasparetto, Michael Kauffman, Sumit Madan, Richard Leblanc, Muhamed Baljevic, Christopher P. Venner, Ohad S. Bentur, Suzanne Lentzsch, Darrell White, Sascha A. Tuchman, Rami Kotb, Noa Biran, Chris Zhiyi Zhang, Christine Chen, Michael Sebag, Sharon Shacham, Adriana C Rossi, Brea Lipe, Gary J. Schiller, Natalie S. Callander, Dane Van Domelen, Andrew DeCastro, Osnat Ben-Shahar, Tianjun Zhou
Publikováno v:
British Journal of Cancer
British journal of cancer, vol 126, iss 5
British journal of cancer, vol 126, iss 5
Background Proteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor of nuclear export (SINE) compound, in preclinical models of multiple myeloma (MM). Methods The safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb51c167cd70da25a86b1eb4fcbb800f
https://pubmed.ncbi.nlm.nih.gov/34802051
https://pubmed.ncbi.nlm.nih.gov/34802051
Autor:
Sharon Shacham, William I. Bensinger, Jatin J. Shah, Richard Leblanc, Sumit Madan, Suzanne Lentzsch, Muhamed Baljevic, Noa Biran, Nizar J. Bahlis, Dane Van Domelen, Michael Sebag, Gary J. Schiller, Brea Lipe, Ohad S. Bentur, Rami Kotb, Natalie S. Callander, Heather J. Sutherland, Christine Chen, Andrew DeCastro, Jorge Monge, Cristina Gasparetto, Michael Kauffman, Christopher P. Venner, Sascha A. Tuchman, Darrell White
Publikováno v:
Blood. 138:1651-1651
Background: Once multiple myeloma (MM) becomes refractory to αCD38 mAb, pts have limited effective treatment options and poor prognoses. With standard therapies, overall response rate (ORR) to the first regimen after refractoriness to an αCD38 mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05c676e6f9648a66d492934076593b8f
https://doi.org/10.1182/blood-2021-150232
https://doi.org/10.1182/blood-2021-150232
Autor:
Brea Lipe, Jorge Monge, Chris Zhang, Jatin J. Shah, Gary J. Schiller, Dane Van Domelen, Sharon Shacham, Rami Kotb, Muhamed Baljevic, Sumit Madan, William I. Bensinger, Darrell White, Merav Leiba, Michael Kauffman, Ohad S. Bentur, Sascha A. Tuchman, Moran Mishal, Andrew DeCastro, Heather J. Sutherland, Noa Biran, Michael Sebag, Noa Lavi, Cristina Gasparetto, Richard Leblanc, Christopher P. Venner, Suzanne Lentzsch, Tamar Tadmor, Natalie S. Callander, Evgeni Chubar, Christine Chen, Nizar J. Bahlis
Publikováno v:
Blood. 138:2748-2748
Background: Overexpression of the nuclear export protein exportin 1 (XPO1) mediates the functional inactivation of tumor suppressor proteins (TSPs), facilitates the export of oncogene mRNA thus facilitating oncoprotein expression, is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76747bb1286702656d461fb8038c7216
https://doi.org/10.1182/blood-2021-148759
https://doi.org/10.1182/blood-2021-148759
Autor:
Xavier Leleu, Sundar Jagannath, Reuben Benjamin, Dinesh Kumar Sinha, Jatin P. Shah, Tuphan Kanti Dolai, Veselina S Goranova Marinova, Tadeusz Robak, Monica Galli, Hang Quach, Supratik Basu, Ashraf Z. Badros, Paul G. Richardson, Dane Van Domelen, Craig T. Wallington-Beddoe, Maryana Simonova, Philippe Moreau, Artur Jurczyszyn, Chris Venner, Atanas Radinoff, Sebastian Grosicki, Eirini Katodritou, Roman Hájek, Mercedes Gironella Mesa, Moran Mishal, Yi Chai, Halyna Pylypenko, Sosana Delimpasi, Anna Marina Liberati, Galina Salogub, Jelena Bila, Don A. Stevens, Moshe Yair Levy, Sharon Shacham, Iryna Kriachok, Andrew DeCastro, Mamta Garg, Ohad S. Bentur, Holger W. Auner, Michael Kauffman, Ganna Usenko, Ivan Spicka, Thierry Facon, Maria Gavriatopoulou, Vadim A Doronin
Publikováno v:
Blood. 138:3793-3793
Introduction: Treatment of multiple myeloma (MM) has greatly improved over the last two decades. However, most pts will relapse and develop refractory disease. Most anti-cancer regimens require dose modifications (interruption, reduction, or disconti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75f9f1457870e3b50da70f8952844936
https://doi.org/10.1182/blood-2021-146003
https://doi.org/10.1182/blood-2021-146003