Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dane Ford-Roshon"'
Autor:
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The RNF43 G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood. In this study, the authors show that RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibit
Externí odkaz:
https://doaj.org/article/f27b6baf1c414b9d98b4607879f425b8
Autor:
Marios Giannakis, Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O'Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng
Publikováno v:
Cancer Research. 82:PR009-PR009
Introduction: The RNF43 p.G659fs mutation occurs with a frequency of approximately 8% in colorectal cancer (CRC) and is enriched among microsatellite-instability high tumors. However, despite RNF43 being implicated as a Wnt-signaling tumor suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b333177eb37019ee67c52f6f01bcda
https://doi.org/10.1158/1538-7445.crc22-pr009
https://doi.org/10.1158/1538-7445.crc22-pr009
Autor:
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Publikováno v:
Nature communications. 13(1)
The RNF43_p.G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood and there are no specific therapies directed against this alteration. In this study, we find that RNF43_p.G659fs promotes cell growth indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c82884223074291f0cdf308b93b3bc
https://pubmed.ncbi.nlm.nih.gov/35676246
https://pubmed.ncbi.nlm.nih.gov/35676246
Autor:
Miju Kim, Seav Huong Ly, Yingtian Xie, Gina N. Duronio, Dane Ford-Roshon, Justin H. Hwang, Rita Sulahian, Jonathan P. Rennhack, Jonathan So, Ole Gjoerup, Jessica A. Talamas, Maximilien Grandclaudon, Henry W. Long, John G. Doench, Nilay S. Sethi, Marios Giannakis, William C. Hahn
Publikováno v:
Dev Cell
The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration, and tumorigenesis. Multiple cancers are dependent on sustained expression of YAP1 for cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a189b9cf303ee3c6b3a0012373f45f
https://doi.org/10.1016/j.devcel.2021.12.006
https://doi.org/10.1016/j.devcel.2021.12.006
Autor:
Max Russo, Namrata D. Udeshi, Kimmie Ng, Casey O’Brien, Marios Giannakis, Steven M. Corsello, Maximilien Grandclaudon, Carino Gurjao, Srivatsan Raghavan, Dane Ford-Roshon, Lishan Fang, Ewa Sicinska, James Berstler
Publikováno v:
Cancer Research. 81:960-960
Introduction: RNF43 is a transmembrane E3 ubiquitin ligase and WNT signaling suppressor that is commonly mutated in colorectal cancer (CRC). A C-terminal RNF43 hotspot mutation, RNF43_G659fs, occurs in approximately 36% (55/151) of microsatellite-ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7faf45d60bb4e919779ae5adc995c173
https://doi.org/10.1158/1538-7445.am2021-960
https://doi.org/10.1158/1538-7445.am2021-960