Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dane E Karr"'
Autor:
Timothy D. Owens, Patrick F. Smith, Andrew Redfern, Yan Xing, Jin Shu, Dane E. Karr, Sonja Hartmann, Michelle R. Francesco, Claire L. Langrish, Philip A. Nunn, Steven G. Gourlay
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 442-450 (2022)
Abstract Bruton’s tyrosine kinase (BTK), expressed in B cells and cells of innate immunity, including microglia, is an essential signaling element downstream of the B‐cell receptor and Fc‐receptors. Tolebrutinib (PRN2246, SAR442168) is a potent
Externí odkaz:
https://doaj.org/article/738e75a6a2de41d5ad5259c40a952c3b
Autor:
J. Michael Bradshaw, Jens Oliver Funk, David M. Goldstein, Mary E. Gerritsen, Ronald J. Hill, Dane E. Karr, Kwan Leung, Jacob LaStant, Danny Tam, Yan Xing, Timothy D. Owens, Erik Verner, Vernon T. Phan, Ken A. Brameld, Eleni Venetsanakos
Supplementary Table S1. Percentage of enzyme activity following dialysis compared to a non-compound treated control; Supplementary Figure S1. PRN1371 inhibited SNU16 cell proliferation as assessed by BrdU incorporation; Supplementary Figure S2. PRN13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5e9e9ff8205d0aa30e44bc8c20f2ed
https://doi.org/10.1158/1535-7163.22503429.v1
https://doi.org/10.1158/1535-7163.22503429.v1
Autor:
Dane E. Karr, Michelle Francesco, Sonja Hartmann, Yan Xing, Steven G. Gourlay, Jin Shu, Claire L. Langrish, Philip A. Nunn, Timothy D. Owens, Patrick F. Smith, Andrew Redfern
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 442-450 (2022)
Bruton’s tyrosine kinase (BTK), expressed in B cells and cells of innate immunity, including microglia, is an essential signaling element downstream of the B‐cell receptor and Fc‐receptors. Tolebrutinib (PRN2246, SAR442168) is a potent BTK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dedda727997316de02c40b25d7c0e3b
https://doi.org/10.1111/cts.13162
https://doi.org/10.1111/cts.13162
Autor:
Daniel W. Robbins, Nivetha Brathaban, Dane E. Karr, Austin Tenn-McClellan, Arthur T. Sands, Jun Ma, May Tan, Gwenn M. Hansen, Timothy Ingallinera, Jenny McKinnell, Cristiana Guiducci, Ryan Rountree, Aileen Kelly, Zef Konst, Luz Perez, Mark Noviski
Publikováno v:
Blood. 138:2251-2251
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, and covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, have proven efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f9e8e6d28add21cfafc5080ef439b17
https://doi.org/10.1182/blood-2021-147473
https://doi.org/10.1182/blood-2021-147473
Autor:
Ryan Rountree, Dane E Karr, Luz Perez, Austin Tenn-McClellan, G. Hansen, Jenny McKinnell, Zef Konst, Mark Noviski, M. Tan, Aileen Kelly, Timothy Ingallinera, Daniel W. Robbins, Cristiana Guiducci
Publikováno v:
Annals of the Rheumatic Diseases. 80:204.1-205
Background:Aberrant activation of B cells and autoantibody mediated tissue damage are hallmarks of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Therefore, novel treatments that prevent autoantibody gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8105690a77d5a499911df154f261b6c2
https://doi.org/10.1136/annrheumdis-2021-eular.1675
https://doi.org/10.1136/annrheumdis-2021-eular.1675
Autor:
Jennifer Tung, Luz Perez, Timothy Ingallinera, Jordan Ye, Aileen Kelly, May Tan, Ge Peng, Sasha Borodovsky, Zef Konst, Austin Tenn-McClellan, Ryan Rountree, Steve Basham, Jeffrey H. Wu, Jenny McKinnell, Dahlia Weiss, Arthur T. Sands, Cristiana Guiducci, Mark Noviski, Mcintosh Joel, Dane E Karr, Janine Powers, Daniel W. Robbins, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic
Publikováno v:
Blood. 136:34-34
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, such as chronic lymphocytic leukemia (CLL). Covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, while effective, have been associated with the occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492f0dbdb2ad9ad3c62ea1d2da14dc82
https://doi.org/10.1182/blood-2020-141461
https://doi.org/10.1182/blood-2020-141461
Autor:
Li Tan, Hao Zhang, Darin Hildebrandt, Yushen Guo, Dane E. Karr, Donald E. Schmidt, Kenneth B. Wlasichuk
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 111:126-130
Amino carbamate adduct formation from the amino group of an aminoglycoside and carbon dioxide has been postulated as a mechanism for reducing nephrotoxicity in the aminoglycoside class compounds. In this study, sisomicin was used as a model compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e7647375ac01bf80b9fedc0c62306d
https://doi.org/10.1016/j.jpba.2015.03.033
https://doi.org/10.1016/j.jpba.2015.03.033
Autor:
Christoph W. Zapf, May Tan, Mario G. Cardozo, Ge Peng, Jennifer Tung, Mcintosh Joel, Arthur T. Sands, Ryan Rountree, Zef Konst, Jordan Ye, Aileen Kelly, Jeffrey H. Wu, Luz Perez, Neil Bence, Timothy Ingallinera, Dahlia Weiss, Mark Noviski, Steve Basham, Austin Tenn-McClellan, Jenny McKinnell, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic, Daniel W. Robbins, Dane E Karr
Publikováno v:
Blood. 134:3805-3805
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor signaling and is involved in B cell development and function. BTK plays a crucial role in cell survival in B cell malignancies such as Chronic Lymphocytic Leukemia (CLL), and covale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b95ae450ec2bc4afe8f06a32c74d624
https://doi.org/10.1182/blood-2019-129262
https://doi.org/10.1182/blood-2019-129262
Autor:
Kevin M. Krause, Bettina Bazzini, J. Kevin Judice, Burton G. Christensen, Michael R. Leadbetter, Dane E. Karr, Sean G. Trapp, Elizabeth Soriano, Jeng-Pyng Shaw, Paul R. Fatheree, Kelly L. Quast, Lam Bernice M T, Martin S. Linsell, Matthew B. Nodwell, Terry X. Wu, John L. Pace, Jenny D. Villena, Stacy M. Adams
Publikováno v:
The Journal of Antibiotics. 57:326-336
Novel derivatives of N-decylaminoethylvancomycin (2), containing appended hydrophilic groups were synthesized and their antibacterial activity and ADME properties were evaluated. The compounds were prepared by reacting amines with the C-terminus (C-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6222c56379e55f3952bdb5a808e761
https://doi.org/10.7164/antibiotics.57.326
https://doi.org/10.7164/antibiotics.57.326
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:406-412
A novel high-performance liquid chromatography tandem mass spectrometry (LC/MS/MS) method is described for the determination of vancomycin in serum and urine. After the addition of internal standard (teicoplanin), serum and urine samples were directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bfd9b240186551c827900b1ee1659b
https://doi.org/10.1002/rcm.246
https://doi.org/10.1002/rcm.246