A divergent protein kinase A in the human pathogenLeishmaniais associated with cell cortex microtubules and controls cell shape

Autor: Michael Boshart, Almoznino M, Fischer Weinberger R, Dandugudumula R, Githure G, Polatoglou E, Dan Zilberstein, Polina Tsigankov, Peter J. Myler, Isabelle Q. Phan, Sabine Bachmaier, Nitzan Koren R

SummaryParasitic protozoa of the genusLeishmaniacycle between the phagolysosome of mammalian macrophages, where they reside as rounded intracellular amastigotes, and the midgut of female sand flies, which they colonize as elongated extracellular prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8dc12630f858fc2986aa6eebe449453
https://doi.org/10.1101/2021.04.24.440790

Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani

Autor: R. Ayana, Preeti Yadav, Rajesh Kumari, Dandugudumula Ramu, Swati Garg, Soumya Pati, Shailja Singh

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Palmitoylation has been recently identified as an important post-translational rheostat for controlling protein function in eukaryotes. However, the molecular machinery underlying palmitoylation remains unclear in the neglected tropical parasite, Lei

Externí odkaz: https://doaj.org/article/b34f160e0760488eaa08f1a3891f68ea

A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania.

Autor: Fischer Weinberger R; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel., Bachmaier S; Faculty of Biology, Genetics, Ludwig-Maximilians Universität München, Martinsried, Germany., Ober V; Faculty of Biology, Genetics, Ludwig-Maximilians Universität München, Martinsried, Germany., Githure GB; Faculty of Biology, Genetics, Ludwig-Maximilians Universität München, Martinsried, Germany., Dandugudumula R; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel., Phan IQ; Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington, United States of America.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America., Almoznino M; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel., Polatoglou E; Faculty of Biology, Genetics, Ludwig-Maximilians Universität München, Martinsried, Germany., Tsigankov P; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel., Nitzan Koren R; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel., Myler PJ; Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington, United States of America.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.; Department of Pediatrics, Department of Biomedical Informatics & Medical Education, and Department of Global Health, University of Washington, Seattle, Washington, United States of America., Boshart M; Faculty of Biology, Genetics, Ludwig-Maximilians Universität München, Martinsried, Germany., Zilberstein D; Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 Mar 29; Vol. 20 (3), pp. e1012073. Date of Electronic Publication: 2024 Mar 29 (Print Publication: 2024).