Výsledky vyhledávání - "Dandepally Srinivasa Reddy"

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Autor: Heather B. Miller, Dandepally Srinivasa Reddy, Nagaswamy Kumaragurubaran, Gerald Koelsch, Xiao Ming Xu, Jordan Tang, Lin Hong, Arun K. Ghosh, Robert T. Turner, Sarang Kulkarni, Wanpin Chang, Vajira Weerasena

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:1031-1036

Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic beta-secretase inhibitors incorporating hydroxyethylamine isosteres are described. We have identified inhibitor 24 which has shown exceedingly potent activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef874ac124046e9e81fbdc7b40bdb747
https://doi.org/10.1016/j.bmcl.2007.12.028

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Diastereoselective Reformatsky reaction of methyl 4-bromocrotonate with 1,2:5,6-di-O-isopropylidene-α-d-ribo-hexofuranos-3-ulose: application to novel bicyclic nucleosides

Autor: Mohan M. Bhadbhade, Dandepally Srinivasa Reddy, Rajesh G. Gonnade, Mukund K. Gurjar

Publikováno v: Tetrahedron. 60:10269-10275

This paper describes an efficient synthetic route for novel bicyclic nucleosides. The stereochemistry of the targeted bicyclic nucleosides was successfully achieved by vinylogous Reformatsky reaction and ring closing metathesis reaction on a carbohyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d8b03332143f4099638f6375994093b
https://doi.org/10.1016/j.tet.2004.08.092

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A New Route to Prepare 6-Chloro-5-(2-chloroethyl)oxindole

Autor: Mukund K. Gurjar, A. M. S. Murugaiah, Dandepally Srinivasa Reddy, Mukund S. Chorghade

Publikováno v: Organic Process Research & Development. 7:309-312

6-Chloro-5-(2-chloroethyl)oxindole, a key intermediate in the manufacturing of the antipsychotic drug, ziprasidone, has been synthesized by a new route. The salient features of the synthesis are (1) bis-dialkylation of 2,4-difluoro-5-chloronitrobenze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57c1ff42703c810e71be5182fa9de14c
https://doi.org/10.1021/op020095k

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Carbohydrate based formal synthesis of stemoamide using ring-closing metathesis

Autor: Mukund K. Gurjar, Dandepally Srinivasa Reddy

Publikováno v: Tetrahedron Letters. 43:295-298

A synthesis of stemoamide has been achieved from D-glucose. The stereocontrolled allylation under Barbier reaction conditions led to the installation of the 2-pyrrolidinone ring at C-3 followed by a ring-closing metathesis approach to construct the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c741b538f333de26b55252079645d4b
https://doi.org/10.1016/s0040-4039(01)02052-4

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