Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Danda Chapagai"'
Autor:
Jessy Stafford, Danda Chapagai, George Merhej, Justin Pressley, Chintada Nageswara-Rao, Michael Wyatt, Campbell Mcinnes
Publikováno v:
Cancer Research. 83:4993-4993
Polo-like kinase 1 (PLK1) has a plethora of roles within the cell of which mitotic regulation is the best characterized. This kinase is overexpressed and upregulated in cancer cells, making it an attractive target for therapeutics. Drug discovery eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b08533fdee3d70a9fce734b51e332a
https://doi.org/10.1158/1538-7445.am2023-4993
https://doi.org/10.1158/1538-7445.am2023-4993
Autor:
Merissa Baxter, Elmar Nurmemmedov, Diego Altomare, Jessy M. Stafford, Danda Chapagai, Campbell McInnes, Sandra Craig, Michael D. Wyatt
Publikováno v:
Eur J Med Chem
Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase involved in cell cycle regulation and mitotic progression. Studies have shown that PLK1 is upregulated in many tumors and high levels are adversely related to a poor prognosis. Knocking d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969aa721b201d9bdb16662138b80e111
https://europepmc.org/articles/PMC9137042/
https://europepmc.org/articles/PMC9137042/
Autor:
Michael D. Wyatt, Gurusankar Ramamoorthy, Danda Chapagai, Campbell McInnes, Jessy Varghese, Elmar Nurmemmedov
Publikováno v:
Journal of medicinal chemistry. 64(14)
PLK1, polo-like kinase 1, is a central player regulating mitosis. Inhibition of the subcellular localization and kinase activity of PLK1 through the PBD, polo-box domain, is a viable alternative to ATP-competitive inhibitors, for which the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf4903942e8ae81e16004bde6c71393
https://pubmed.ncbi.nlm.nih.gov/34210138
https://pubmed.ncbi.nlm.nih.gov/34210138
Autor:
Danda Chapagai, Merissa Baxter, Sandra Craig, Guru Ramamoorthy, Jessy Stafford, Sikirzhytski Vitali, Elmar Nurmemmedov, Campbell McInnes, Michael D. Wyatt
Publikováno v:
Cancer Research. 82:2572-2572
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is overexpressed in many tumor types. PLK1 inhibition selectively kills cancer cells because they are dependent on the mitotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819a92c8aff3c9b63b0ee0197c56f064
https://doi.org/10.1158/1538-7445.am2022-2572
https://doi.org/10.1158/1538-7445.am2022-2572
Autor:
Michael D. Wyatt, Sandra Craig, Merissa Baxter, Jessy Varghese, Danda Chapagai, Campbell McInnes, Cecilia Hurtado, Elmar Nurmemmedov
Publikováno v:
ChemMedChem
The polo-box domain (PBD) of PLK1 determines mitotic substrate recognition and subcellular localization. Compounds that target PLK1 selectively are required due to the tumor-suppressor roles of PLK3. A structure-activity analysis of the PBD phosphope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645740c0fb010eb5bbde88b4927e93d9
https://europepmc.org/articles/PMC7703809/
https://europepmc.org/articles/PMC7703809/
Autor:
Michael D. Wyatt, Sandra Craig, Elmar Nurmemmedov, McInnes Campbell, Danda Chapagai, Merissa Baxter, Guru Ramamoorthy
Publikováno v:
Cancer Research. 81:1241-1241
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of various origins while its expression is largely absent in normal tissues. PLK1 inhibition sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e5be833e71e108181b7a18994d63b2
https://doi.org/10.1158/1538-7445.am2021-1241
https://doi.org/10.1158/1538-7445.am2021-1241
Publikováno v:
Cancer Research. 79:4712-4712
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of various origins while its expression is largely absent in normal tissues. PLK1 inhibition sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7022b6bf9699d91e9b408e8bf37701ad
https://doi.org/10.1158/1538-7445.am2019-4712
https://doi.org/10.1158/1538-7445.am2019-4712
Autor:
Jianning Wei, Vijaya Iragavarapu, John Mallow, Houjun Jia, Michael D. Perttunen, Michael L. Lu, Danda Chapagai
Publikováno v:
Cancer Research. 78:3453-3453
Centrosome abnormalities are linked to genomic instability and are considered one possible cause of cancer progression. In prostate and breast cancer, centrosome over-duplication is correlated with lymph node and distant metastasis. In prostate cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e07bfad2b474f2eeed27cffc9f5d6b2
https://doi.org/10.1158/1538-7445.am2018-3453
https://doi.org/10.1158/1538-7445.am2018-3453
Publikováno v:
Elucidation of Abiotic Stress Signaling in Plants ISBN: 9781493922109
Biotic and abiotic stresses are significant factors limiting the production of food and other supporting materials required to sustain increasing world population. Plant health is directly related to human health and is increasingly becoming signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eaa1b0de3825d5370993e4e905ce54f
https://doi.org/10.1007/978-1-4939-2211-6_12
https://doi.org/10.1007/978-1-4939-2211-6_12
Hormone Signaling: Current Perspectives on the Roles of Salicylic Acid and Its Derivatives in Plants
Autor:
Danda Chapagai, Mir A. Hossain, Imdadul Haq, Dhirendra Kumar, Diwaker Tripathi, David Donald, Shivakumar P. Devaiah
Publikováno v:
The Formation, Structure and Activity of Phytochemicals ISBN: 9783319203966
Salicylic acid (SA) is an important plant hormone with a wide range of effects on plant growth and metabolism. Plants lacking SA exhibit enhanced susceptibility to pathogens. SA plays important signaling roles in resistance against biotrophic and hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbfcbba0321533d9e8ae75f9740756e3
https://doi.org/10.1007/978-3-319-20397-3_5
https://doi.org/10.1007/978-3-319-20397-3_5