Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Autor: Moore C; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Blumhagen RZ; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Yang IV; 3 Department of Medicine, and., Walts A; 3 Department of Medicine, and., Powers J; 3 Department of Medicine, and., Walker T; 3 Department of Medicine, and., Bishop M; 3 Department of Medicine, and., Russell P; 1 National Jewish Health, Denver, Colorado., Vestal B; 1 National Jewish Health, Denver, Colorado., Cardwell J; 3 Department of Medicine, and., Markin CR; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Mathai SK; 3 Department of Medicine, and., Schwarz MI; 3 Department of Medicine, and., Steele MP; 3 Department of Medicine, and., Lee J; 3 Department of Medicine, and., Brown KK; 1 National Jewish Health, Denver, Colorado., Loyd JE; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Crapo JD; 1 National Jewish Health, Denver, Colorado.; 3 Department of Medicine, and., Silverman EK; 5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts., Cho MH; 5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts., James JA; 6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Guthridge JM; 6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Cogan JD; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Kropski JA; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Swigris JJ; 1 National Jewish Health, Denver, Colorado., Bair C; 1 National Jewish Health, Denver, Colorado., Kim DS; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Ji W; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Kim H; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Song JW; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Maier LA; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health.; 3 Department of Medicine, and., Pacheco KA; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Hirani N; 8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.; 9 Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Poon AS; 9 Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Li F; 8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Jenkins RG; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Braybrooke R; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Saini G; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Maher TM; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Molyneaux PL; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Saunders P; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Zhang Y; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Gibson KF; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Kass DJ; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Rojas M; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Sembrat J; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Wolters PJ; 13 Department of Medicine, University of California, San Francisco, San Francisco, California., Collard HR; 13 Department of Medicine, University of California, San Francisco, San Francisco, California., Sundy JS; 14 Gilead Sciences, Foster City, California., O'Riordan T; 14 Gilead Sciences, Foster City, California., Strek ME; 15 Department of Medicine, University of Chicago, Chicago, Illinois., Noth I; 16 Department of Medicine, University of Virginia, Charlottesville, Virginia., Ma SF; 16 Department of Medicine, University of Virginia, Charlottesville, Virginia., Porteous MK; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Kreider ME; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Patel NB; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Inoue Y; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Hirose M; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Arai T; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Akagawa S; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Eickelberg O; 3 Department of Medicine, and.; 20 Helmholtz Zentrum München, Neuherberg, Germany., Fernandez IE; 20 Helmholtz Zentrum München, Neuherberg, Germany., Behr J; 21 University Hospital Munich, Munich, Germany., Mogulkoc N; 22 Department of Pulmonology, Ege University Hospital, Bornova, Izmir, Turkey., Corte TJ; 23 Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia., Glaspole I; 24 Alfred Hospital and Monash University, Melbourne, Australia., Tomassetti S; 25 Pulmonary Medicine, GB Morgagni Hospital, Forlì, Italy., Ravaglia C; 26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy., Poletti V; 26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy., Crestani B; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Borie R; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Kannengiesser C; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Parfrey H; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Fiddler C; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Rassl D; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Molina-Molina M; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Machahua C; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Worboys AM; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Gudmundsson G; 30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland., Isaksson HJ; 30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland., Lederer DJ; 31 Department of Medicine, Columbia University Irving Medical Center, New York, New York., Podolanczuk AJ; 31 Department of Medicine, Columbia University Irving Medical Center, New York, New York., Montesi SB; 32 Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts., Bendstrup E; 33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark., Danchel V; 33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark., Selman M; 34 Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosio Villegas,' México City, México., Pardo A; 35 Universidad Nacional Autónoma de México, México City, México., Henry MT; 36 Cork University Hospital and University College Cork, Cork, Ireland., Keane MP; 37 St. Vincent's University Hospital, Dublin, Ireland.; 38 School of Medicine, University College Dublin, Dublin, Ireland., Doran P; 37 St. Vincent's University Hospital, Dublin, Ireland.; 38 School of Medicine, University College Dublin, Dublin, Ireland., Vašáková M; 39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic., Sterclova M; 39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic., Ryerson CJ; 40 University of British Columbia, Vancouver, Canada., Wilcox PG; 40 University of British Columbia, Vancouver, Canada., Okamoto T; 3 Department of Medicine, and.; 41 Tokyo Medical and Dental University, Tokyo, Japan., Furusawa H; 3 Department of Medicine, and.; 41 Tokyo Medical and Dental University, Tokyo, Japan., Miyazaki Y; 41 Tokyo Medical and Dental University, Tokyo, Japan., Laurent G; 42 Institute for Respiratory Health and.; 43 Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Perth, Australia., Baltic S; 42 Institute for Respiratory Health and., Prele C; 42 Institute for Respiratory Health and.; 43 Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Perth, Australia., Moodley Y; 42 Institute for Respiratory Health and., Shea BS; 44 Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island., Ohta K; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Suzukawa M; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Narumoto O; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Nathan SD; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Venuto DC; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Woldehanna ML; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Kokturk N; 46 Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey., de Andrade JA; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Luckhardt T; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Kulkarni T; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Bonella F; 48 Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Essen, Germany., Donnelly SC; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., McElroy A; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Armstong ME; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Aranda A; 50 CardioPulmonary Reserach Center, Alliance Pulmonary Group, Guaynabo, Puerto Rico., Carbone RG; 51 Department of Internal Medicine, University of Genoa, Genoa, Italy., Puppo F; 51 Department of Internal Medicine, University of Genoa, Genoa, Italy., Beckman KB; 52 Biomedical Genomics Center, University of Minnesota; Minneapolis, Minnesota; and., Nickerson DA; 53 Northwest Genomics Center, University of Washington, Seattle, Washington., Fingerlin TE; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health.; 3 Department of Medicine, and., Schwartz DA; 1 National Jewish Health, Denver, Colorado.; 3 Department of Medicine, and.; 54 Department of Immunology, University of Colorado Denver, Denver, Colorado.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Jul 15; Vol. 200 (2), pp. 199-208.