Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Danai S. Gkotsi"'
Autor:
Nikolina Piteša, Matea Kurtović, Nenad Bartoniček, Danai S. Gkotsi, Josipa Čonkaš, Tina Petrić, Vesna Musani, Petar Ozretić, Natalia A. Riobo-Del Galdo, Maja Sabol
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1353 (2023)
Background: Melanoma represents the deadliest skin cancer due to its cell plasticity which results in high metastatic potential and chemoresistance. Melanomas frequently develop resistance to targeted therapy; therefore, new combination therapy strat
Externí odkaz:
https://doaj.org/article/7811c878ae2d499a90e99e0c7299f803
Autor:
Katharine Davis, Danai S. Gkotsi, Duncan R. M. Smith, Rebecca J. M. Goss, Lorenzo Caputi, Sarah E. O’Connor
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Plant secondary metabolites have applications for the food, biofuel, and pharmaceutical industries. Recent advances in pathway elucidation and host expression systems now allow metabolic engineering of plant metabolic pathways to produce “new-to-na
Externí odkaz:
https://doaj.org/article/e329153a04ac41bab6b390ffbe57ce64
Autor:
Mimmu K. Hiltunen, Alex J. Timmis, Maren Thomsen, Danai S. Gkotsi, Hideo Iwaï, Orquidea M. Ribeiro, Adrian Goldman, Natalia A. Riobo-Del Galdo
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2682
Volume 24
Issue 3
Pages: 2682
Deleterious mutations in the X-linked Patched domain-containing 1 (PTCHD1) gene may account for up to 1% of autism cases. Despite this, the PTCHD1 protein remains poorly understood. Structural similarities to Patched family proteins point to a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe28975316e3bc1c9542e9040d20420
Autor:
Begoña Caballero-Ruiz, Danai S. Gkotsi, Hattie Ollerton, Cintli C. Morales-Alcala, Rosa Bordone, Georgia M. L. Jenkins, Laura Di Magno, Gianluca Canettieri, Natalia A. Riobo-Del Galdo
Publikováno v:
Cancers; Volume 15; Issue 2; Pages: 369
The Hedgehog receptor, Patched1 (PTCH1), is a well-known tumour suppressor. While the tumour suppressor’s activity is mostly ascribed to its function as a repressor of the canonical Smoothened/Gli pathway, its C-terminal domain (CTD) was reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdeff41a230a032f22348c048011327
Autor:
Rebecca J. M. Goss, Samuel Molyneux, Helen Connaris, Ying Zhang, Charlotte Crowe, Danai S. Gkotsi, Sunil V. Sharma
Publikováno v:
Chemical Society Reviews
The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of compounds, opening up the opportunity for selective C–H functionalisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7faf77d8994fbff639479937968612
http://europepmc.org/articles/PMC8407142
http://europepmc.org/articles/PMC8407142
Autor:
Sarah E. O'Connor, Katharine Davis, Duncan R. M. Smith, Lorenzo Caputi, Rebecca J. M. Goss, Danai S. Gkotsi
Publikováno v:
Frontiers in Plant Science
Frontiers in Plant Science, Vol 11 (2020)
Frontiers in Plant Science, Vol 11 (2020)
Authors gratefully acknowledge the Max Planck Society, ERA-IB project NBCPBH-EIB.13.008 (SO’C and RG) and ERC 788301 (SO’C). Plant secondary metabolites have applications for the food, biofuel, and pharmaceutical industries. Recent advances in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70e3614a4472f4d06e5a9342dca5f6a
https://hdl.handle.net/21.11116/0000-0007-A080-221.11116/0000-0007-A07D-821.11116/0000-0007-A07F-6
https://hdl.handle.net/21.11116/0000-0007-A080-221.11116/0000-0007-A07D-821.11116/0000-0007-A07F-6
Autor:
Yunpeng Wang, Stephen E. Shanahan, Richard J. K. Taylor, Rebecca J. M. Goss, Danai S. Gkotsi, Jack A. Connolly, Hannes Ludewig, Jagwinder Dhaliwal, Matthew M. W. McLachlan, William P. Unsworth, James H. Naismith, Sunil V. Sharma
We thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013/ERC grant agreement no. 614779 GenoChemetics to R.J.M.G.), Syngenta and Wellcome ISSF (grant no. 204821/Z/16/Z to D.S.G.) for generous fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f06dd85e509dccd214f98051dc7ff
https://eprints.whiterose.ac.uk/152554/1/Revised_VirX1_210619_1_WPU_edit_AAM.docx
https://eprints.whiterose.ac.uk/152554/1/Revised_VirX1_210619_1_WPU_edit_AAM.docx
Autor:
Danai S, Gkotsi, Hannes, Ludewig, Sunil V, Sharma, Jack A, Connolly, Jagwinder, Dhaliwal, Yunpeng, Wang, William P, Unsworth, Richard J K, Taylor, Matthew M W, McLachlan, Stephen, Shanahan, James H, Naismith, Rebecca J M, Goss
Publikováno v:
Nature chemistry. 11(12)
Oceanic cyanobacteria are the most abundant oxygen-generating phototrophs on our planet and are therefore important to life. These organisms are infected by viruses called cyanophages, which have recently shown to encode metabolic genes that modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b425222cedf460f772354259d2108588
https://pubmed.ncbi.nlm.nih.gov/31758155
https://pubmed.ncbi.nlm.nih.gov/31758155
Autor:
Danai S. Gkotsi, Rebecca J. M. Goss, Qin Zhu, Xinyu Liu, Kuljira Ittiamornkul, Matthew L. Hillwig, Duncan R. M. Smith, Nicole Nightingale
Publikováno v:
Chemical Science
Promiscuous cis-indolyl vinyl isonitrile biosynthetic pathway allowed the preparatively useful generation of nine halosubstituted antibiotic analogues with increased lipophilicity.
The hapalindole-type alkaloids naturally show striking late stag
The hapalindole-type alkaloids naturally show striking late stag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0db2f4f02720f3dfa07b90e0057bfed
https://doi.org/10.1039/c5sc02919h
https://doi.org/10.1039/c5sc02919h
Autor:
Rebecca J. M. Goss, Jag Dhaliwal, Matthew M. W. McLachlan, Keith R Mulholand, Danai S. Gkotsi
Publikováno v:
Current opinion in chemical biology. 43
The market sizes for halogenated compounds are huge; in contrast to synthetic chemical alternatives, halogenating enzymes afford the highly regiospecific incorporation of a halogen into an organic molecule, there is therefore great opportunity for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c6c231b49294ac082b47f4500b1e60
https://pubmed.ncbi.nlm.nih.gov/29414530
https://pubmed.ncbi.nlm.nih.gov/29414530