Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Danae Bowen"'
Autor:
Sunwoo Oh, Elodie Bournique, Danae Bowen, Pégah Jalili, Ambrocio Sanchez, Ian Ward, Alexandra Dananberg, Lavanya Manjunath, Genevieve P. Tran, Bert L. Semler, John Maciejowski, Marcus Seldin, Rémi Buisson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multi
Externí odkaz:
https://doaj.org/article/f03f488fd0c5499ab43ab73627e76395
Autor:
Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimal
Externí odkaz:
https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
Autor:
Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven
Externí odkaz:
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
Autor:
Michael S. Lawrence, Angela G. Fleischman, Kevin Aguirre, Shinho Park, Adam Langenbucher, Ryan B. Corcoran, Lee Zou, Danae Bowen, Pégah Jalili, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c3c4b8e16d7e2d814a9408e1b3c84e
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
Publikováno v:
Journal of Clinical Oncology. 40:2537-2537
2537 Background: In recent years, there has been promising progress in the use of immune checkpoint blockade (ICB) as a treatment for various cancer types such as lung, kidney, bladder, skin, colon, and breast cancer. In order for this modality to ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0689bbbb4f9864bb699a6d9ffbd72343
https://doi.org/10.1200/jco.2022.40.16_suppl.2537
https://doi.org/10.1200/jco.2022.40.16_suppl.2537
Autor:
Danae Bowen, Ashok S. Bhagwat, Ramin Sakhtemani, Michael S. Lawrence, Adam Langenbucher, Jillian F. Wise, Rémi Buisson, Elodie Bournique, Lee Zou
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2ad5be2d6de7df9ad5881d9103ccb0
https://escholarship.org/uc/item/6hf407s2
https://escholarship.org/uc/item/6hf407s2
Autor:
Danae Bowen, Adam Langenbucher, Rémi Buisson, Cyril H. Benes, Michael S. Lawrence, Eugene E. Kwan, Lee Zou
Publikováno v:
Science (New York, N.Y.), vol 364, iss 6447
INTRODUCTION: Extensive tumor sequencing efforts have transformed the way in which cancer driver genes are identified. Appropriate statistical modeling is crucial for distinguishing true drivers from passenger events that accumulate during tumorigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c6759b2a4f798a2df68d6c5820d8d5
https://doi.org/10.1126/science.aaw2872
https://doi.org/10.1126/science.aaw2872