Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dana de Gracia Hahn"'
Autor:
Harriet Hunter, Dana de Gracia Hahn, Amedine Duret, Yu Ri Im, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcan McKeown, Claudia-Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A Rowe, Jake P Mann
Publikováno v:
eLife, Vol 9 (2020)
The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however there is a low conversion rate from success in animals to humans. Non-alcoholic fatty liver disease (NAFLD)
Externí odkaz:
https://doaj.org/article/e3d2a6b4f51e4f3e833552afae4730a8
Autor:
Yu Ri Im, Hong Kai Lim, Qinrong Cheah, Harriet Hunter, Jiawen Dong, Mrudula Utukuri, Dana de Gracia Hahn, Jake P. Mann, Ian A. Rowe, Amedine Duret, Alice Li, Lorcan McKeown, Madison Fairey, Clarissa Hjalmarsson, Raunak Rao, Claudia Gabriela Mitrofan
Publikováno v:
Hepatology. 74:1884-1901
Background and aims Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD. Approach and results We generated a database of 3,920 rodent models of NAFLD.
Publikováno v:
American Journal of Gastroenterology. 114:556-559
Nonalcoholic fatty liver disease and hypertension are closely related but there has been little genetic evidence to link them. In this issue, Musso et al. provide evidence that a common variant in AGTR1 (A1166C) is associated with both incident hyper
Publikováno v:
Journal of Forensic and Legal Medicine. 88:102350
Deliberate airway obstruction is a well-recognised form of child abuse and one of the most common causes of death in cases of child homicide. Although classical signs such as petechial haemorrhages can be helpful in raising the suspicion of mechanica
Autor:
Qinrong Cheah, Lorcan McKeown, Harriet Hunter, Amedine Duret, Jiawen Dong, Alice Li, Yu Ri Im, Madison Fairey, Jake P. Mann, Claudia-Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Hong Kai Lim, Clarissa Hjalmarsson, Dana de Gracia Hahn, Ian A. Rowe
SummaryAnimal models of human disease are a key component of translational research and yet there is often no consensus on which model is optimal for a particular disease. Here, we generated a database of 3,920 rodent models of non-alcoholic fatty li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fc3297d03e1ac606d08f616624ce43
https://doi.org/10.1101/2020.12.15.422799
https://doi.org/10.1101/2020.12.15.422799
Autor:
Alice Li, Claudia-Gabriela Mitrofan, Amedine Duret, Qinrong Cheah, Harriet Hunter, Yu Ri Im, Madison Fairey, Lorcan McKeown, Ian A. Rowe, Raunak Rao, Mrudula Utukuri, Hong Kai Lim, Jiawen Dong, Dana de Gracia Hahn, Clarissa Hjalmarsson, Jake P. Mann
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however there is a low conversion rate from success in animals to humans. Non-alcoholic fatty liver disease (NAFLD)
Autor:
Hong Kai Lim, Yu Ri Im, Lorcan McKeown, Qinrong Cheah, Harriet Hunter, Ian A. Rowe, Madison Fairey, Jake P. Mann, Raunak Rao, Dana de Gracia Hahn, Amedine Duret, Clarissa Hjalmarsson, Alice Li, Claudia-Gabriela Mitrofan, Jiawen Dong, Mrudula Utukuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217d7e0454fae463b67cb6afd5788dad
https://doi.org/10.7554/elife.56573.sa2
https://doi.org/10.7554/elife.56573.sa2
Autor:
Jesus M. Banales, Jerome I. Rotter, Connor A. Emdin, Leon A. Adams, Sreekumar G. Pillai, Stephan Buch, Yu Ri Im, Thomas Berg, Claudia Langenberg, Kendra A. Young, Felix Stickel, Elizabeth K. Speliotes, Julia Kozlitina, Sonia Caprio, Madison Fairey, Kevin Teo, Hanieh Yaghootkar, Abhijit Chowdhury, Eu-Pnafld Investigators, Yii-Der Ida Chen, Harriet Hunter, Faiza Qayyum, Pavel Strnad, Matthias C. Reichert, Elmar Aigner, Marcin Krawczyk, Dana de Gracia Hahn, Lin Li, Matthew Hickman, Nicholette D. Palmer, Panu K. Luukkonen, Jiawen Dong, Christian Datz, Ali Canbay, Kent D. Taylor, Joel E. Lavine, Philip E. Melton, Nicola Santoro, Richard M. Watanabe, Xiuqing Guo, Giuseppina Rosaria Umano, Lynne E. Wagenknecht, Amedine Duret, Pallav Bhatnagar, Trevor A. Mori, Johanna K. DiStefano, Anne Tybjærg-Hansen, Stefano Romeo, Julia Wattacheril, Jake P. Mann, Luca Valenti, Ankita Chatterjee, Stefan Stender, Jochen Hampe, Rajarshi Banerjee, Glenn S. Gerhard, Frank Lammert, Rohit Loomba, Christian A. Hudert, Kushala W M Abeysekera, L Heintz, Constantinos A. Parisinos, Hong Kai Lim, Christopher D. Still, Matt Kelly, Mrudula Utukuri, Priyadarshi Basu, Nicholas J. Wareham, Hannele Yki-Järvinen, Clemens Schafmayer
Background & AimsA common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however, these findings have not been consistently replicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda14bc28df5a8b42ed9b0199a3750e4
https://doi.org/10.1101/19013623
https://doi.org/10.1101/19013623
Autor:
Duret A; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work., de Gracia Hahn D; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work., Hunter H; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work., Im YR; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work., Mann JP; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work.; School of Clinical Medicine, University of Cambridge, Cambridge, UK. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Paediatrics, University of Cambridge, Cambridge, UK. Amedine Duret, Dana de Gracia Hahn, Harriet Hunter and Yu Ri Im contributed equally to this work. Jake P. Mann supervised this work.
Publikováno v:
The American journal of gastroenterology [Am J Gastroenterol] 2018 May; Vol. 113 (5), pp. 775. Date of Electronic Publication: 2018 Feb 16.