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Autor:
Karl Dean, Apurva Chaudhary, Dana Wambser, Oljan Repic, Martin Mueller, Hui Liu, Joginder S. Bajwa, Helmut Boehnke, Kathryn Rene Bracken, Paul G. Lee, Thomas J. Blacklock, Vivelo James Anthony, Joseph Carosi, Kapa Prasad, Michael J. Girgis, Joel Slade, Guang-Pei Chen, David Thomas Parker
Publikováno v:
Organic Process Research & Development. 10:78-93
A practical synthesis of the peptide deformylase inhibitor LBM415, (2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[(formylhydroxyamino)methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide, magnesium salt 11, is described. The key chiral intermediate, (2S)-N