Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Dana W. Aswad"'
Publikováno v:
Amino acids, vol 55, iss 4
Approximately 12% of histone H2B molecules in mammalian brain contain a modification wherein Asp25 is present as the d-enantiomer, and is mostly linked to Gly26 via the side-chain carboxyl. Here we (1) demonstrate the high specificity of a polyclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a3eacba193bb41d51a01d0310220e7
https://escholarship.org/uc/item/1051p2jt
https://escholarship.org/uc/item/1051p2jt
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198266 (2018)
Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an
Externí odkaz:
https://doaj.org/article/b23ade4a1bcd4298ab786242dd987e51
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100622 (2014)
Isoaspartate (isoAsp) formation is a common type of spontaneous protein damage that is normally kept in check by the repair enzyme protein-L-isoaspartyl methyltransferase (PIMT). PIMT-KO (knockout) mice exhibit a pronounced neuropathology highlighted
Externí odkaz:
https://doaj.org/article/bce3fdb4ae0f4c53bab1770727b18227
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80758 (2013)
Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT). Mice deficient in PIMT accumulate isoAsp-containing proteins, resulting in cognitive d
Externí odkaz:
https://doaj.org/article/d5d91b042e6942449a2095cdad9a6dfc
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43288 (2012)
Protein L-isoaspartyl methyltransferase (PIMT) repairs abnormal isoaspartyl peptide bonds in age-damaged proteins. It has been reported that synuclein, a protein implicated in neurodegenerative diseases, is a major target of PIMT in mouse brain. To e
Externí odkaz:
https://doaj.org/article/d4bb3c39781c485297ec1621fa247eae
Autor:
Jean-Louis Bru, Katherine Nguyen, Baihe Chen, Dana W. Aswad, Eric Huynh, Charity Juang, Mahsa Momen, Jeungjin Kim
Publikováno v:
Journal of Biological Chemistry. 292:3656-3665
Protein l-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the human pcmt1 gene, catalyzes repair of abnormal l-isoaspartyl linkages in age-damaged proteins. Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198266 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198266 (2018)
Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an
Autor:
Stephen V. Liu, Jan J.G.M. Verschuuren, Diane Kang, Meleeneh Kazarian DerHartunian, Eric M. Chung, Zhenxia Qin, Andrew W. Woodham, W. Martin Kast, Mario A. Pulido, Lina Wang, Jeffrey A. Tsou, Ite A. Laird-Offringa, Rinse Klooster, Dana W. Aswad, Omid Akbari
Publikováno v:
Journal of Neuroimmunology, 299, 70-78
Pulido, MA; DerHartunian, MK; Qin, Z; Chung, EM; Kang, DS; Woodham, AW; et al.(2016). Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. JOURNAL OF NEUROIMMUNOLOGY, 299, 70-78. doi: 10.1016/j.jneuroim.2016.09.002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/43v5k0mg
Pulido, MA; DerHartunian, MK; Qin, Z; Chung, EM; Kang, DS; Woodham, AW; et al.(2016). Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. JOURNAL OF NEUROIMMUNOLOGY, 299, 70-78. doi: 10.1016/j.jneuroim.2016.09.002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/43v5k0mg
Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f56f236743df0aa4a26e228289e8356
http://hdl.handle.net/1887/112622
http://hdl.handle.net/1887/112622
Publikováno v:
Amino acids, vol 48, iss 2
Approximately 12 % of histone H2B in mammalian brain contains an unusual D-aspartate residue in its N-terminal tail. Most of this D-aspartate is linked to the C-flanking glycine via an isopeptide bond. To explore the possible significance of these mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6386e33f66e922b18162567b5ad40bff
https://escholarship.org/uc/item/1rx3z9f0
https://escholarship.org/uc/item/1rx3z9f0
Autor:
Jeff X. Zhu, Dana W. Aswad
Publikováno v:
Analytical Biochemistry. 364:1-7
Formation of atypical isoaspartyl (isoAsp) sites in peptides and proteins via the deamidation-linked isomerization of asparaginyl-Xaa bonds or direct isomerization of aspartyl-Xaa bonds is a major contributor to spontaneous protein damage under mild