Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dana Vardeman"'
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 16, Iss 1 (2013)
Purpose. The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48, a C20-propionate ester of camptothecin (CPT) in mice. Methods. In this study, the
Externí odkaz:
https://doaj.org/article/4d1c3546eca84bbf914a74ff0b9803ed
Autor:
Douglas R. Coil, John Mendoza, Dana Vardeman, Beppino C. Giovanella, Constantine S.A. Markides, Tony Kozielski, Linh H. Luong
Publikováno v:
Oncology Letters
Desmoplastic small round cell tumor (DSRCT) is an extremely rare and aggressive neoplasm, which mainly affects young males and generally presents as a widely disseminated tumor within the peritoneal cavity. Due to the rarity of the tumor, its younger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0cac116578d1c743d620a9cbc34bc4
http://europepmc.org/articles/PMC3678573
http://europepmc.org/articles/PMC3678573
Publikováno v:
Biomedical Reports. 1:202-206
Crystalline camptothecin-20-O-propionate hydrate (CZ48) is an esterification product from the reaction of natural camptothecin with propionic anhydride. CZ48 has been tested against 29 human tumor lines grown in nude mice as xenografts. Of the tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71fb92f7a8d42e6e5818989791d92d5
https://doi.org/10.3892/br.2013.55
https://doi.org/10.3892/br.2013.55
Autor:
Beppino C. Giovanella, Xing Liu, Dana Vardeman, A. J. Kozielski, Zhisong Cao, Yang Wang, Chang-Guo Zhan, Albert DeJesus, John Mendoza
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 12:818-828
All chemotherapeutic agents currently in use have a narrow window of therapeutic index of 1 to 1.2. Camptothecin ester compounds are reported to have a wider therapeutic index when being used to treat human xenografts in nude mice. As a continuous ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d394d5ac2ce7a076cda05f8405afe0c
https://doi.org/10.2174/187152012802650219
https://doi.org/10.2174/187152012802650219
Publikováno v:
Open Journal of Medicinal Chemistry. :10-14
Camptothecin-20-propinate (CZ48) and other camptothecin ester derivatives were prepared by the esterification reac-tions of camptothecin or 9-nitrocamptothecin with the corresponding acylating agents such as organic acid anhydride or chloride with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bc9dd0c81d9f550d3d61e07c51606c
https://doi.org/10.4236/ojmc.2012.21002
https://doi.org/10.4236/ojmc.2012.21002
Publikováno v:
Cancer Research. 69:4742-4749
To find a more effective and less toxic chemotherapeutic agent, we have successfully prepared crystalline camptothecin-20(S)-O-propionate hydrate (CZ48) by reacting camptothecin with propionic anhydride using concentrated sulfuric acid as catalyst. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc452f460143431da4a4e9eb399561a1
https://doi.org/10.1158/0008-5472.can-08-4452
https://doi.org/10.1158/0008-5472.can-08-4452
Publikováno v:
Journal of Chromatography B. 867:84-89
A simple and sensitive high-performance liquid chromatography (HPLC) assay for the analysis of CZ48, a potent anticancer candidate, and its active metabolite camptothecin (CPT) in mouse plasma was developed and validated. CZ44 was used as an internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d5bb4a7671811b72490a92242636b6
https://doi.org/10.1016/j.jchromb.2008.03.013
https://doi.org/10.1016/j.jchromb.2008.03.013
Autor:
John S. Stehlin, Nick Harris, Dana Vardeman, Beppino C. Giovanella, Zhisong Cao, Anthony J. Kozielski
Publikováno v:
Journal of Medicinal Chemistry. 41:31-37
Eleven camptothecin esters, 6a-e and 7a-f, were prepared by straightforward acylation of camptothecins with the corresponding acylating reagents such as organic anhydrides and carboxylic acid chlorides. The in vitro pharmacokinetic determination of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c9a42366e95350d30b1d89f015a244
https://doi.org/10.1021/jm9607562
https://doi.org/10.1021/jm9607562
Publikováno v:
Annals of the New York Academy of Sciences. 803:181-187
Thirty-five human tumors of various histological types xenografted at various sites into nude mice and rats have been used to assess the anticancer activity of camptothecin and derivatives administered by different routes (subcutaneous, intramuscular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48805bd819571b100b0dab5104a102e8
https://doi.org/10.1111/j.1749-6632.1996.tb26387.x
https://doi.org/10.1111/j.1749-6632.1996.tb26387.x
Autor:
Dana Vardeman, Albert DeJesus, Janet Early, John Mendoza, A. J. Kozielski, Panayotis Pantazis, Beppino C. Giovanella
Publikováno v:
Leukemia Research. 19:43-55
Human leukemia U-937 cell clones resistant to 9-nitrocamptothecin (9NC) appear after exposure to increase 9NC-concentrations. Drug resistance is irreversible, regardless of whether the 9NC-resistant (U-937/CR150) cells grow in media with or without 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb8d6c7b8964c055d023444ebaf1517
https://doi.org/10.1016/0145-2126(94)00060-n
https://doi.org/10.1016/0145-2126(94)00060-n