Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dana Ungermannova"'
Autor:
Dana Ungermannova, Seth J Parker, Christopher G Nasveschuk, Wei Wang, Bettina Quade, Gan Zhang, Robert D Kuchta, Andrew J Phillips, Xuedong Liu
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29208 (2012)
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers. Consequently, developing inhibitors of the u
Externí odkaz:
https://doaj.org/article/2a8a5c698f3449d8a82141713b9f224b
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Supplementary Data from Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66cc0ba3e4bb3154d809f1ce9e18868
https://doi.org/10.1158/1535-7163.22522086
https://doi.org/10.1158/1535-7163.22522086
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. Although HDAC inhibitors are active in T-cell lymphomas, poor isoform selectivity, narrow therapeutic indices, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca10d3d7a768f89abeba39b0600ff66
https://doi.org/10.1158/1535-7163.c.6543273
https://doi.org/10.1158/1535-7163.c.6543273
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Supplementary Figure from Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21396584792a719c719476ad7fe8d703
https://doi.org/10.1158/1535-7163.22522083
https://doi.org/10.1158/1535-7163.22522083
Autor:
Jennifer R. Diamond, Todd M. Pitts, Dana Ungermannova, Christopher G. Nasveschuk, Gan Zhang, Andrew J. Phillips, Stacey M. Bagby, Jessica Pafford, Betelehem W. Yacob, Timothy P. Newton, John J. Tentler, Brian Gittleman, Sarah J. Hartman, John A. DeMattei, James D. Winkler, Michael K. Wendt, William P. Schiemann, S. Gail Eckhardt, Xuedong Liu, Anthony D. Piscopio
Publikováno v:
Mol Cancer Ther
Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. Although HDAC inhibitors are active in T-cell lymphomas, poor isoform selectivity, narrow therapeutic indices, a
Autor:
Junglim Lee, Charles S. McHenry, H. Garry Dallmann, Xuedong Liu, Dana Ungermannova, Gan Zhang
Publikováno v:
SLAS Discovery. 18:910-920
Decreased levels of cell cycle inhibitor p27(Kip1) due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27(Kip1) expression has been associated with a poor prognosis in many human cancers and resistance to certai
Publikováno v:
Journal of Biological Chemistry. 280:30301-30309
p27Kip1 is an essential cell cycle inhibitor of Cyclin-dependent kinases. Ubiquitin-mediated proteolysis of p27Kip1 is an important mechanism for activation of Cyclin E-Cdk2 and facilitates G1/S transition. Ubiquitination of p27 is primarily catalyze
Autor:
Dana Ungermannova, Xuedong Liu, Min Liang, Yao-Yun Liang, Xiao-Ping Wang, Xia Lin, F. Charles Brunicardi, Katharine H. Wrighton, Xin-Hua Feng
Publikováno v:
Molecular and Cellular Biology. 24:7524-7537
Smad4/DPC4, a common signal transducer in transforming growth factor beta (TGF-beta) signaling, is frequently inactivated in human cancer. Although the ubiquitin-proteasome pathway has been established as one mechanism of inactivating Smad4 in cancer
Publikováno v:
Oncogene. 23:1064-1075
TGF-beta is a multifunctional growth factor whose best-known function is to inhibit cell growth and suppress tumor formation. TGF-beta causes cells to accumulate in mid-to-late G1 phase by blocking the transition from G1 to S. It has been shown that
A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure−activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374f401dfd4b788ea3b65a59f3df876b
https://europepmc.org/articles/PMC2664405/
https://europepmc.org/articles/PMC2664405/