SURF2 is a MDM2 antagonist in triggering the nucleolar stress response

Autor: Sophie Tagnères, Paulo Espirito Santo, Julie Radermecker, Dana Rinaldi, Carine Froment, Quentin Provost, Manon Bongers, Solemne Capeille, Nick Watkins, Julien Marcoux, Pierre-Emmanuel Gleizes, Virginie Marcel, Célia Plisson-Chastang, Simon Lebaron

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as “nucleolar stress” (NS), triggering p53-dependent and independent pathways l

Externí odkaz: https://doaj.org/article/fd1b3098e42d421d8ee03f99b039a140

The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography

Autor: Franck Delavoie, Vanessa Soldan, Dana Rinaldi, Jean-Yves Dauxois, Pierre-Emmanuel Gleizes

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Large protein complexes and ribonucleoprotein particles (RNPs) such as pre-ribosomes are transported from the nucleus to the cytoplasm through the nuclear pore complex (NPC). Here the authors use ultrafast freezing and electron tomography to catch sn

Externí odkaz: https://doaj.org/article/2ac35b113c5741eebe5bb4209d6e5eea

Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy

Autor: Ramtin Shayan, Dana Rinaldi, Natacha Larburu, Laura Plassart, Stéphanie Balor, David Bouyssié, Simon Lebaron, Julien Marcoux, Pierre-Emmanuel Gleizes, Célia Plisson-Chastang

Publikováno v: Molecules, Vol 25, Iss 5, p 1125 (2020)

Assembly of eukaryotic ribosomal subunits is a very complex and sequential process that starts in the nucleolus and finishes in the cytoplasm with the formation of functional ribosomes. Over the past few years, characterization of the many molecular

Externí odkaz: https://doaj.org/article/c76148e046f248f78e743d2dd4fc06e8

The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

Autor: Christian Montellese, Ramtin Shayan, Pierre-Emmanuel Gleizes, Carine Froment, Julien Marcoux, Laura Plassart, Célia Plisson-Chastang, Simon Lebaron, Carole Pichereaux, Natacha Larburu, Marie-Françoise O'Donohue, Dana Rinaldi, Ulrike Kutay

Publikováno v: eLife, 10
eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.61254⟩
eLife, Vol 10 (2021)

Preventing premature interaction of pre-ribosomes with the translation apparatus is essential for translational accuracy. Hence, the final maturation step releasing functional 40S ribosomal subunits, namely processing of the 18S ribosomal RNA 3′ en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf0bfab01a1d15fd5d083e5985829f3
https://hdl.handle.net/20.500.11850/485505

Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

Autor: Pierre-Emmanuel Gleizes, Sarah Weigl, Valentin Mitterer, Hajrija Omanic, Guillaume Murat, Dana Rinaldi, Ramtin Shayan, Célia Plisson-Chastang, Dieter Kressler, Brigitte Pertschy, Sébastien Ferreira-Cerca, Tanja Enne

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-10678-z⟩
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
'Nature Communications ', vol: 10, pages: 2754-1-2754-15 (2019)

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre-ribosomes are coordinated is poorly understood. Using functional analyses and cryo-E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c5d5019ea7d310a89f287fffec1633
http://doc.rero.ch/record/326945/files/kre_cpd.pdf