Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dana Pueschl"'
Autor:
Jennifer B. Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D’Andrea, Anna P. Hubert, Jake S. Shilan, Wenting Zhou, Adam A. Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J. Morin, Anupma Nayak, Kara N. Maxwell, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Carriers of pathogenic BRCA1/2 variants have a higher risk of breast and ovarian cancers, which recur frequently. Here, the authors sequence primary and recurrent tumours of BRCA1/2 mutation carriers, finding PARP1 amplifications, differential BRCA2
Externí odkaz:
https://doaj.org/article/86e2b8acb27543e9aad8ac4d1b5b8463
Autor:
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine R. Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Jonathan Belman, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflamm
Externí odkaz:
https://doaj.org/article/f380b6f884834140a346b9249d88cbb6
Autor:
Kate L. Loveland, Britta Klein, Dana Pueschl, Sivanjah Indumathy, Martin Bergmann, Bruce E. Loveland, Mark P. Hedger, Hans-Christian Schuppe
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline ce
Externí odkaz:
https://doaj.org/article/0334cca436b24472b7bc85492ca4e66b
Autor:
Carole Le Coz, Derek A. Oldridge, Ramin S. Herati, Nina De Luna, James Garifallou, Emylette Cruz Cabrera, Jonathan P. Belman, Dana Pueschl, Luisa V. Silva, Ainsley V. C. Knox, Whitney Reid, Samuel Yoon, Karen B. Zur, Steven D. Handler, Hakon Hakonarson, E. John Wherry, Michael Gonzalez, Neil Romberg
Publikováno v:
Science Immunology. 8
The mechanisms by which FOXP3 + T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe or vaccine recognition and away from self-reactivity remain incompletely understood. To explore underappreciated heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0472f75aac0a8266e4d78de04c9ff024
https://doi.org/10.1126/sciimmunol.ade8162
https://doi.org/10.1126/sciimmunol.ade8162
Autor:
Carole Le Coz, Derek A. Oldridge, Ramin S. Herati, Nina De Luna, James Garifallou, Emylette Cruz Cabrera, Jonathan P Belman, Dana Pueschl, Luisa V. Silva, Ainsley V. C. Knox, Samuel Yoon, Karen B. Zur, Steven D. Handler, Hakon Hakonarson, E. John Wherry, Michael Gonzalez, Neil Romberg
How FOXP3+T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe/vaccine recognition and away from self-reactivity remains unsettled. To explore human Tfr cell provenance, function and location heterogeneity, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f965abb7725532a9a36532a51272e8f
https://doi.org/10.1101/2022.10.26.513910
https://doi.org/10.1101/2022.10.26.513910
Autor:
Dana Pueschl, Derek A. Oldridge, Jonathan Belman, William Chandler, Anupma Nayak, Bradley Wubbenhorst, John Pluta, Michael Feldman, E. John Wherry, Heather Thorne, Georgia Chenevix-Trench, Kathleen Cuningham Foundation Consortium for Resea kConFab, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Cancer Research. 83:4648-4648
The tumor microenvironment (TME) plays important roles in tumor progression, therapy response and patient survival. In this comprehensive study, we performed a detailed multiomic single cell analysis of breast cancers with inherited mutations in diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3952b747ea84e639871ae90f0c8462
https://doi.org/10.1158/1538-7445.am2023-4648
https://doi.org/10.1158/1538-7445.am2023-4648
Autor:
Violeta Serra, Anna Hubert, Catherine Ruan, Judith Balmaña, Alba Llop-Guevara, Kara N. Maxwell, Susan M. Domchek, Anupma Nayak, Wenting Zhou, John Pluta, Dana Pueschl, Michael Feldman, Katherine L. Nathanson, Adam A. Kraya, Jennifer Shah, Bradley Wubbenhorst, Kurt D.Andrea, Jake S. Shilan
Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). We performed multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa9a298919895f5ce68568b13baf94a
https://doi.org/10.21203/rs.3.rs-745248/v1
https://doi.org/10.21203/rs.3.rs-745248/v1
Autor:
Jake S. Shilan, Kara N. Maxwell, Katherine L. Nathanson, Susan M. Domchek, Jonathan Belman, Michael Feldman, E. John Wherry, Anupma Nayak, John Pluta, Bradley Wubbenhorst, Derek A. Oldrige, Dana Pueschl, Robert H. Vonderheide
Publikováno v:
Cancer Research. 81:2723-2723
Breast cancer type 1 and 2 susceptibility proteins (BRCA1/BRCA2) are well known breast cancer genes, mutations in which lead to defective homologous recombination repair (HRR). HR-based DNA repair deficiency (HRD) scores can be used to indicate DNA d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26eec07c0a8b4cdb8ab81d0626cb7b6c
https://doi.org/10.1158/1538-7445.am2021-2723
https://doi.org/10.1158/1538-7445.am2021-2723
Autor:
DANA PUESCHL
Testicular germ cell tumours (TGCTs) are most frequently associated with immune cell infiltrations that include macrophages and DCs. Macrophages and DCs can be involved in tumour progression and tumour destruction. Thus, a characterisation of macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57586c26ee2b7894d3f94e3529dfea7e