Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dana Prukova"'
Autor:
Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Filipp Savvulidi, Tomas Zikmund, Dana Prukova, Diana Tuskova, Magdalena Klanova, Petra Vockova, Lucie Lateckova, Ludek Sefc, Jan Zivny, Marek Trneny, Pavel Klener
Publikováno v:
Haematologica, Vol 102, Iss 4 (2017)
Externí odkaz:
https://doaj.org/article/4939dddb976741d782de82c5c6d12687
Autor:
Pavel Klener, Marek Trneny, Eva Fronkova, Adela Berkova, Petra Vockova, Mariana Pacheco-Blanco, Kristina Forsterova, Karel Helman, Eva Pokorna, Diana Tuskova, Zuzana Zemanova, Karla Svobodova, Jan Soukup, Ondrej Havranek, Magdalena Klanova, Michael Svaton, Jana Karolova, Zuzana Nahacka, Ladislav Andera, Dana Prukova
Purpose:Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f5c886ce44042199a0881ea8008748
https://doi.org/10.1158/1078-0432.c.6528017
https://doi.org/10.1158/1078-0432.c.6528017
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Western blot analysis showing protein expression profile of key regulators of apoptosis in 18 DLBCL cell lines (12 germinal center B-cell-like (GCB) and 6 activated B-cell-like (ABC) DLBCL cell lines). *UPF4D cell line (GCB origin) was derived in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173972cf2e268702b74b82a1e49d1e3
https://doi.org/10.1158/1078-0432.22457130
https://doi.org/10.1158/1078-0432.22457130
Autor:
Pavel Klener, Marek Trneny, Eva Fronkova, Adela Berkova, Petra Vockova, Mariana Pacheco-Blanco, Kristina Forsterova, Karel Helman, Eva Pokorna, Diana Tuskova, Zuzana Zemanova, Karla Svobodova, Jan Soukup, Ondrej Havranek, Magdalena Klanova, Michael Svaton, Jana Karolova, Zuzana Nahacka, Ladislav Andera, Dana Prukova
Supplemental Figure 1. Next-generation sequencing of PDXs and primary MCL cells Supplemental Figure 2. IHC analysis of primary MCL samples and murine xenografts Supplemental Figure 3. Array comparative genomic hybridization of 24 primary MCL samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9434da02e49e1026da548d1f72ae836
https://doi.org/10.1158/1078-0432.22471799
https://doi.org/10.1158/1078-0432.22471799
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Purpose: To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL).Experimental designs: Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f7657670078fc56e9d1f3aa2eb5276
https://doi.org/10.1158/1078-0432.c.6523509.v1
https://doi.org/10.1158/1078-0432.c.6523509.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Shown are examples of different levels of semi-quantitative protein expression (0-3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d072966c6995f80fa38e44a6170501a
https://doi.org/10.1158/1078-0432.22457133
https://doi.org/10.1158/1078-0432.22457133
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
To investigate whether the expression level of BCL2 proteins detected by western blot is comparable with the expression level assessed by IHC analysis, we analyzed protein expression (by IHC) of BCL2, MCL1 and BCL-XL from subcutaneous lymphoma xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63969706514c34ab22db984109d7a24f
https://doi.org/10.1158/1078-0432.22457115.v1
https://doi.org/10.1158/1078-0432.22457115.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
(A) Comparison of the extent of apopotosis induced by HHT (after 24hrs exposure) in HHT-resistant (HHT-R) clones compared to the original cell lines (CTRL). (B) Western blot analysis demonstrates upregulation of BCL-XL protein in HHT-R clones compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883706f3111a5507d671c92a8ec2bf45
https://doi.org/10.1158/1078-0432.22457118
https://doi.org/10.1158/1078-0432.22457118
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
The graphs show the extent of apoptosis of DLBCL cell lines induced by different concentrations of HHT, ABT-199 and ABT-737 after 24hrs exposure to particular agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e50a0a51e72b6007cddc684aa7ff2
https://doi.org/10.1158/1078-0432.22457124.v1
https://doi.org/10.1158/1078-0432.22457124.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Cell of origin (COO), BCL2 expression status and IC100 for ABT-199 (µM) and HHT (nM) are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397d4117a0aff828cfc6dc72b61ae48
https://doi.org/10.1158/1078-0432.22457112.v1
https://doi.org/10.1158/1078-0432.22457112.v1