Výsledky vyhledávání - "Dana Plocova"

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

Autor: Milada Šírová, Tomas Mrkvan, Tomáš Etrych, Petr Chytil, Jiri Strohalm, Dana Plocova, Karel Ulbrich, Blanka Rihova

Publikováno v: Journal of Controlled Release. 110:119-129

A novel class of anti-cancer therapeutics - polymeric conjugates of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers and doxorubicin with pH-controlled release of the drug - is highly efficient in killing tumor cells in vitro and is potent in erad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67b6e89fcf9334da7db111e58634f1
https://doi.org/10.1016/j.jconrel.2005.09.028

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HPMA-hydrogels containing cytostatic drugs

Autor: Tomáš Etrych, Marek Kovář, Blanka Říhová, M. Št'astný, Dana Plocova, Karel Ulbrich

Publikováno v: Journal of Controlled Release. 81:101-111

This study proposes a strategy to generate new anticancer therapy using hydrogel-based drug delivery systems to improve drug bioavailability and increase the therapeutic efficacy. We have synthesized biodegradable hydrogels based on N -(2-hydroxyprop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad0b55d9faa1734457a250b60372306f
https://doi.org/10.1016/s0168-3659(02)00047-0

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Selectivity of Antibody-Targeted Anthracycline Antibiotics on T Lymphocytes

Autor: Karel Ulbrich, Dana Plocova, Jiri Strohalm, Blanka Rihova

Publikováno v: Journal of Bioactive and Compatible Polymers. 5:249-266

Targeted polymeric prodrugs based on N-(2-hydroxypropyl) methacrylamide were tested on human peripheral blood lymphocytes or mouse splenocytes triggered in vitro to proliferation by T cell specific (Con A) or B cell specific (S. aureus Cowan 1) mitog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c8db9fd635b08c13a956cdd28ce3bf5
https://doi.org/10.1177/088391159000500302

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Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers

Autor: Jindrˇich Kopecˇek, Hana Semora´dova´, Pavla Kopecˇkova´-Rejmanova´, Dana Plocova, Blanka Rˇi´hova´, Jirˇi´ Strohalm

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 376:221-233

Soluble synthetic copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) containing different oligopeptide side-sequences were tested as transport molecules for drugs and anti-Thy 1.2 antibodies in affinity therapy. As target cells, T lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2e236c781f56109108014229eb6407
https://doi.org/10.1016/s0378-4347(00)80839-7

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The Activity of Complement in the Presence of N-(2-hydroxypropyl)methacrylamide Copolymers

Autor: Jindřich Kopeček, Blanka Rihova, Dana Plocova, J. Šimečková

Publikováno v: Journal of Bioactive and Compatible Polymers. 1:20-31

This study indicates that N-(2-hydroxypropyl)methacrylamide homopolymers and copolymers containing oligopeptide sequences terminated in carboxylic acid groups, amine groups, aromatic units, or puromycin have no prominent effect on the porcine complem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13cb2aa2000ef17befb407147313bda4
https://doi.org/10.1177/088391158600100103

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Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model

Autor: Stanley B. Kaye, Gilmour J.Morrison, Jindrich Kopecek, Jim Cassidy, Dana Plocova, Ruth Duncan, Jiri Strohalm

Publikováno v: Biochemical pharmacology. 38(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335b85e781ee11975595b542722b8c1c
https://pubmed.ncbi.nlm.nih.gov/2930589

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