Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dana Most"'
Publikováno v:
Monday, April 24.
Autor:
Dana Most, Yuri A. Blednov, R. Adron Harris, Nihal A. Salem, R. Dayne Mayfield, Gayatri R. Tiwari
Publikováno v:
Addict Biol
Chronic alcohol consumption alters the levels of microRNAs and mRNAs in the brain, but the specific microRNAs and processes that target mRNAs to affect cellular function and behavior are not known. We examined the in vivo manipulation of previously i
Publikováno v:
Neuropharmacology. 86:397-407
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics
Autor:
Abraham Zangen, Leor N. Katz, Yechiel Levkovitz, Eiran Vadim Harel, Aharon Sheer, Moshe Isserles, Dana Most
Publikováno v:
Brain Stimulation, Vol 4, Iss 4, Pp 266-274 (2011)
Background Apathy is one hallmark of major depression (MDD). It is distinguished by lack of emotion, whereas other aspects of depression involve considerable emotional distress. Investigating both apathy and depression may increase the degree of trea
Publikováno v:
Handbook of clinical neurology. 125
Acute alcohol intoxication causes cellular changes in the brain that last for hours, while chronic alcohol use induces widespread neuroadaptations in the nervous system that can last a lifetime. Chronic alcohol use and the progression into dependence
Autor:
Gizelle Robinson, Yuri A. Blednov, R. Adron Harris, Dana Most, Jody Mayfield, Laura B. Ferguson
Publikováno v:
International review of neurobiology. 118
Immune or brain proinflammatory signaling has been linked to some of the behavioral effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent models, and ethanol intake activates the immune system in multiple models.
Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(2)
Local translation of mRNAs in the synapse has a major role in synaptic structure and function. Chronic alcohol use causes persistent changes in synaptic mRNA expression, possibly mediated by microRNAs localized in the synapse. We profiled the transcr
Publikováno v:
The pharmacogenomics journal. 15(2)
Chronic alcohol consumption changes gene expression, likely causing persistent remodeling of synaptic structures via altered translation of mRNAs within synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes (SNs) and