Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dana Marcovici-Mizrahi"'
Autor:
Dana Marcovici-Mizrahi, Dennis Flint, Vernon A. Wittenbach, Ayelet Nudelman, Abraham Nudelman
Publikováno v:
Tetrahedron. 60:1731-1748
Isosteric derivatives and analogues of the 7-keto-8-aminopelargonic acid (KAPA), 7,8-diaminopelargonic acid (DAPA) and desthiobiotin (DTB) vitamer intermediates involved in the biosynthetic pathway of biotin were prepared and evaluated as potential h
Autor:
Joseph C. Calabrese, Ayelet Nudelman, Alan R. Rendina, Zdislaw Wawrzak, Dana Marcovici-Mizrahi, George H. Lorimer, Wendy Sue Taylor, Gunter Schneider, Abraham Nudelman, Bruce A. Lockett, W. Huang, Guang Yang, Kevin T. Kranis, Dennis R. Rayner, Barry Arthur Wexler, Ylva Lindqvist, Hongji Chi, Eileen Marsilii, Katharine J. Gibson, Jia Jia
Publikováno v:
Pesticide Science. 55:236-247
Dethiobiotin synthetase (DTBS; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in
Publikováno v:
Bioorganic Chemistry. 26:157-168
An efficient synthetic pathway for the preparation of the vitamers of biotin which provides easy access to optically pure KAPA as well as diastereomeric mixtures of DAPA, DTB, and analogs thereof has been developed.