Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Dana M. R. Jenkins"'
Autor:
Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford, Jung-whan Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell ca
Externí odkaz:
https://doaj.org/article/978e7e9cf1334033ac7b7717d1595249
Autor:
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana M. R. Jenkins, Hyunsung Choi, Jung-whan Kim, Masataka Asagiri, Andrew S. Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S. Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while pr
Externí odkaz:
https://doaj.org/article/656cb902beff4390965095a7899b983e
Autor:
Hyunsung Choi, Joshua H. Choe, Masaki Wake, Hiroko Endo, Robin J. Ruthenborg, Min Chen, John D. Minna, Masahiro Inoue, Dana M. R. Jenkins, Jung Whan Kim, Ji Yun Jeong, Maddox W. Robinson, Norihiko Takeda, Pankaj K. Singh, David B. Shackelford, Hajime Abe, Hyuntae Yoo, Kristi L. Helke, Michael L. Neugent, Zhenyu Xuan, Jung-Mo Ahn, Justin Goodwin, Shin Yup Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77a6e6e0a45d4a454715ec7e73c0add
https://doi.org/10.1038/ncomms15503
https://doi.org/10.1038/ncomms15503
Autor:
Ichiro Manabe, Yuki Sugiura, Ryozo Nagai, Yoshifumi Yamaguchi, Takayuki Isagawa, Kurara Honda, Masaki Wake, Keimon Sayama, Katsura Soma, Randall S. Johnson, Hajime Abe, Hiroaki Semba, Norihiko Takeda, Manami Katoh, Katsuhiro Koyama, Andrew S. Cowburn, Dana M. R. Jenkins, Jung Whan Kim, Issei Komuro, Nobuhito Goda, Hyunsung Choi, Masayuki Miura, Masataka Asagiri, Hidenobu Miyazawa
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0784b57733fc30c52cee05356570b74
http://europepmc.org/articles/PMC4873978
http://europepmc.org/articles/PMC4873978