Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dana M. Klug"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/0f2b847142f74e518b6ce0db61ac7a90
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiag
Externí odkaz:
https://doaj.org/article/d32dd50bf4c74ebf995a90e8b2cf426f
Autor:
Dana M. Klug, Fahima I. M. Idiris, Mark A. T. Blaskovich, Frank von Delft, Christopher G. Dowson, Claas Kirchhelle, Adam P. Roberts, Andrew C. Singer, Matthew H. Todd
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
There is an increasingly urgent need for new antibiotics, yet there is a significant and persistent economic problem when it comes to developing such medicines. The problem stems from the perceived need for a “market” to drive commercial antibiot
Externí odkaz:
https://doaj.org/article/df05fc79dd3d41b8bdc6d7e16f2cc0f5
Publikováno v:
F1000Research, Vol 9 (2020)
In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around the world. The global impact of the disease has caused significant and repeated calls for quick action towards new medicines and vaccines. In response, researche
Externí odkaz:
https://doaj.org/article/24c0208fd98940b695ee4196a6f3e2a5
Autor:
Dana M. Klug, Nelly El-Sakkary, Cristina Bosch-Navarrete, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Guiomar Pérez-Moreno, Jeremiah D. Momper, Carlos Cordon-Obras, Francisco Gamarro, Dolores Gonzalez Pacanowska, Maria Santos Martinez-Martinez, Lori Ferrins, Conor R. Caffrey, Eftychia M. Mavrogiannaki, Katherine C. Forbes, Raquel García-Hernández, Claudia Gómez-Liñán, Miguel Navarro, Andreu Saura, Luis M. Ruiz-Pérez, Pilar Manzano, Ali Syed, Lisseth Silva, Michael P. Pollastri
Publikováno v:
J Med Chem
Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases ha
Autor:
Lori Ferrins, Erika Araujo, Matthew W. Boudreau, Melissa C. Grenier-Davies, Krupanandan Haranahalli, V. Blair Journigan, Dana M. Klug, Margaret E. Olson
Publikováno v:
Journal of medicinal chemistry. 65(9)
The Young Medicinal Chemists Committee (YMCC) is a part of the larger ACS Division of Medicinal Chemistry (MEDI) and was formed to ensure that MEDI meets the needs of
Autor:
Julia Medeiros Souza, Everton M Silva, Jessey Erath, Diane Thomas, James H. McKerrow, Lori Ferrins, Baljinder Singh, Erica Penn, Robert F. Campbell, Jair L. Siqueira-Neto, Ana Rodriguez, Jean A. Bernatchez, Susan E. Leed, Norma Roncal, Hitesh B. Jalani, Jasmin Ackermann, Michael P. Pollastri, Dana M. Klug, Laura-Isobel McCall, Kelly A. Bachovchin, Claudia M. Calvet, Richard J. Sciotti, Seema Bag, Melissa J. Buskes
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites includin
Autor:
Lori Ferrins, Melissa J. Buskes, Conor R. Caffrey, Hitesh B. Jalani, Dana M. Klug, Kelly A. Bachovchin, Nelly El-Sakkary, Allison Leonard, Baljinder Singh, Robert F. Campbell, Michael P. Pollastri, Richard J. Sciotti, Seema Bag, Monica Clements
Publikováno v:
ACS Medicinal Chemistry Letters
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity
Autor:
Adam P. Roberts, Andrew C. Singer, Christopher G. Dowson, Mark A. T. Blaskovich, Fahima I. M. Idiris, Claas Kirchhelle, Dana M. Klug, Frank von Delft, Matthew H. Todd
Publikováno v:
Wellcome Open Research
There is an increasingly urgent need for new antibiotics, yet there is a significant and persistent economic problem when it comes to developing such medicines. The problem stems from the perceived need for a “market” to drive commercial antibiot