Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dana M Valerio"'
Autor:
Sharon M. Rymut, Deborah A. Corey, Dana M. Valerio, Bernadette O. Erokwu, Chris A. Flask, Thomas J. Kelley, Craig A. Hodges
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Growth failure in cystic fibrosis (CF) patients has been well-documented and shown to correlate with poorer disease outcomes. This observation is also true in CF animal models, including mouse, pig, rat, and ferret. The etiology underlying g
Externí odkaz:
https://doaj.org/article/fe1f349f88014e678cceaef9c8ae403c
Autor:
Daniel R McHugh, Miarasa S Steele, Dana M Valerio, Alexander Miron, Rachel J Mann, David F LePage, Ronald A Conlon, Calvin U Cotton, Mitchell L Drumm, Craig A Hodges
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199573 (2018)
Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function. There are no currently available animal models which contain a
Externí odkaz:
https://doaj.org/article/77a623ef44c64c4d93965503e6c82613
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175467 (2017)
Growth deficits are common in cystic fibrosis (CF), but their cause is complex, with contributions from exocrine pancreatic insufficiency, pulmonary complications, gastrointestinal obstructions, and endocrine abnormalities. The CF mouse model display
Externí odkaz:
https://doaj.org/article/0b8d49213deb4992a257ad80fb5110c0
Autor:
Nancy M. Walker, Daniel R. McHugh, Austin E. Gillen, George Kotzamanis, Craig A. Hodges, Michael J. Mutolo, Lane L. Clarke, Alexander Miron, Jinghua Liu, Lara R. Gawenis, Calvin U. Cotton, Jürgen Bosch, Ashlee M. Strubberg, Dana M. Valerio, Mitchell L. Drumm, Ann Harris
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would advance in vivo testing of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074bb98cd20b788ff6ceb44903db6adc
http://link.springer.com/article/10.1038/s41598-019-48105-4
http://link.springer.com/article/10.1038/s41598-019-48105-4
Autor:
Thomas J. Kelley, Craig A. Hodges, D. LePage, Mitchell L. Drumm, W. Jiang, R. Mann, Z. Traylor, Dana M. Valerio, R. Conlon
Publikováno v:
Journal of Cystic Fibrosis. 20:S314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711dd53095f022d909340076dee908f8
https://doi.org/10.1016/s1569-1993(21)02085-3
https://doi.org/10.1016/s1569-1993(21)02085-3
Autor:
Edvar Onsoyen, A.H. Myrset, Philip D. Rye, Mitchell L. Drumm, Craig A. Hodges, Megan Vitko, Arne Dessen, Dana M. Valerio
Publikováno v:
Journal of Cystic Fibrosis. 15:745-751
Background Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4b4e8e2619f28b3ca8557aa3017c7d
https://doi.org/10.1016/j.jcf.2016.06.005
https://doi.org/10.1016/j.jcf.2016.06.005
Autor:
Dana M. Valerio, Walter F. Boron, Thomas J. Kelley, Craig A. Hodges, Daniel R. McHugh, Mitchell L. Drumm, Shuyu Hao, Robert C. Stern, Anjum Jafri, Kimberly McBennett, Calvin U. Cotton, Megan Vitko, Fraser J. Moss
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Gastrointestinal dysfunction in cystic fibrosis (CF) is a prominent source of pain among patients with CF. Linaclotide, a guanylate cyclase C (GCC) receptor agonist, is a US Food and Drug Administration-approved drug prescribed for chronic constipati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f71843c8953bd8fd39821669488c23
https://pubmed.ncbi.nlm.nih.gov/30118317
https://pubmed.ncbi.nlm.nih.gov/30118317
Autor:
Ronald A. Conlon, Calvin U. Cotton, Rachel J. Mann, Mitchell L. Drumm, David F. LePage, Dana M. Valerio, Alexander Miron, M. Steele, Craig A. Hodges, Daniel R. McHugh
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199573 (2018)
PLoS ONE
PLoS ONE
Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function. There are no currently available animal models which contain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162fac59d5ca749f213ef1f7aae3df95
http://europepmc.org/articles/PMC6010256?pdf=render
http://europepmc.org/articles/PMC6010256?pdf=render
Autor:
Christine Breindel, Dana M. Valerio, Craig A. Hodges, Lauren Wichman, Saigopal Somasundaram, Ahmad M. Khalil, John R. McCarrey
Publikováno v:
Biology of reproduction. 97(2)
Mammalian reproduction requires that males and females produce functional haploid germ cells through complex cellular differentiation processes known as spermatogenesis and oogenesis, respectively. While numerous studies have functionally characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd21e341639d30f8636ed9ab270d3b1
https://pubmed.ncbi.nlm.nih.gov/29044429
https://pubmed.ncbi.nlm.nih.gov/29044429
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e363dce4a52ca63c347110440915ec37
https://doi.org/10.1096/fasebj.29.1_supplement.861.10
https://doi.org/10.1096/fasebj.29.1_supplement.861.10