Výsledky vyhledávání - "Dana M Brantley-Sieders"

Akademický článek

Determination of the CD148-Interacting Region in Thrombospondin-1.

Autor: Keiko Takahashi, Katherine Sumarriva, Rachel Kim, Rosie Jiang, Dana M Brantley-Sieders, Jin Chen, Raymond L Mernaugh, Takamune Takahashi

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154916 (2016)

CD148 is a transmembrane protein tyrosine phosphatase that is expressed in multiple cell types, including vascular endothelial cells and duct epithelial cells. Previous studies have shown a prominent role of CD148 to reduce growth factor signals and

Externí odkaz: https://doaj.org/article/4c3d21522e9648468c2f1f37a5d9df9e

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Akademický článek

LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer).

Autor: Elizabeth A Simonik, Ying Cai, Katherine N Kimmelshue, Dana M Brantley-Sieders, Holli A Loomans, Claudia D Andl, Grant M Westlake, Victoria M Youngblood, Jin Chen, Wendell G Yarbrough, Brandee T Brown, Lalitha Nagarajan, Stephen J Brandt

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164804 (2016)

Squamous cell carcinoma of the head and neck (HNSCC) accounts for more than 300,000 deaths worldwide per year as a consequence of tumor cell invasion of adjacent structures or metastasis. LIM-only protein 4 (LMO4) and LIM-domain binding protein 1 (LD

Externí odkaz: https://doaj.org/article/b6463e4047624f47887afba64313601f

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Akademický článek

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.

Autor: Meghan M Morrison, Christian D Young, Shan Wang, Tammy Sobolik, Violeta M Sanchez, Donna J Hicks, Rebecca S Cook, Dana M Brantley-Sieders

Publikováno v: PLoS Genetics, Vol 11, Iss 7, p e1005291 (2015)

Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTOR

Externí odkaz: https://doaj.org/article/5f213725e78f4caa83a26de4ea6cc6bf

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Akademický článek

Local breast cancer spatial patterning: a tool for community health resource allocation to address local disparities in breast cancer mortality.

Autor: Dana M Brantley-Sieders, Kang-Hsien Fan, Sandra L Deming-Halverson, Yu Shyr, Rebecca S Cook

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45238 (2012)

Despite available demographic data on the factors that contribute to breast cancer mortality in large population datasets, local patterns are often overlooked. Such local information could provide a valuable metric by which regional community health

Externí odkaz: https://doaj.org/article/320476dd987f43d48bfd55e7fb256cf5

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Akademický článek

Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

Autor: Dana M Brantley-Sieders, Aixiang Jiang, Krishna Sarma, Akosua Badu-Nkansah, Debra L Walter, Yu Shyr, Jin Chen

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24426 (2011)

Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, howe

Externí odkaz: https://doaj.org/article/3741f61fe62647749f16ab646d3b52ca

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Akademický článek

Host deficiency in ephrin-A1 inhibits breast cancer metastasis [version 1; peer review: 2 approved]

Autor: Eileen Shiuan, Ashwin Inala, Shan Wang, Wenqiang Song, Victoria Youngblood, Jin Chen, Dana M. Brantley-Sieders

Publikováno v: F1000Research, Vol 9 (2020)

Background: The conventional dogma of treating cancer by focusing on the elimination of tumor cells has been recently refined to include consideration of the tumor microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein

Externí odkaz: https://doaj.org/article/d77f234c236642d4b20c33c4c9dc8270

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