A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation

Autor: Muntasir Kamal, Jessica Knox, Robert I. Horne, Om Shanker Tiwari, Andrew R. Burns, Duhyun Han, Davide Levy, Dana Laor Bar-Yosef, Ehud Gazit, Michele Vendruscolo, Peter J. Roy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Amyloids are associated with over 50 human diseases and have inspired significant effort to identify small molecule remedies. Here, we present an in vivo platform that efficiently yields small molecule inhibitors of amyloid formation. We pre

Externí odkaz: https://doaj.org/article/32f38f45c042472bbab5c90925875d7e

Erratum for Gupta et al., 'Cytokinin Inhibits Fungal Development and Virulence by Targeting the Cytoskeleton and Cellular Trafficking'

Autor: Rupali Gupta, Gautam Anand, Lorena Pizarro, Dana Laor Bar-Yosef, Neta Kovetz, Noa Sela, Tal Yehuda, Ehud Gazit, Maya Bar

Publikováno v: mBio, Vol 13, Iss 2 (2022)

Externí odkaz: https://doaj.org/article/1191b61537ba4c07b89ada5bc7ee647e

Chemical Chaperones Modulate the Formation of Metabolite Assemblies

Autor: Hanaa Adsi, Shon A. Levkovich, Elvira Haimov, Topaz Kreiser, Massimiliano Meli, Hamutal Engel, Luba Simhaev, Shai Karidi-Heller, Giorgio Colombo, Ehud Gazit, Dana Laor Bar-Yosef

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9172 (2021)

The formation of amyloid-like structures by metabolites is associated with several inborn errors of metabolism (IEMs). These structures display most of the biological, chemical and physical properties of protein amyloids. However, the molecular inter

Externí odkaz: https://doaj.org/article/c7edcc4ef0884e169a48beb1183d106c

Chemical Chaperones Modulate the Formation of Metabolite Assemblies

Autor: Topaz Kreiser, Hamutal Engel, Elvira Haimov, Massimiliano Meli, Shai Karidi-Heller, Giorgio Colombo, Ehud Gazit, Luba Simhaev, Shon A. Levkovich, Dana Laor Bar-Yosef, Hanaa Adsi

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences
22 (2021). doi:10.3390/ijms22179172
info:cnr-pdr/source/autori:Adsi H.; Levkovich S.A.; Haimov E.; Kreiser T.; Meli M.; Engel H.; Simhaev L.; Karidi-Heller S.; Colombo G.; Gazit E.; Bar-Yosef D.L./titolo:Chemical chaperones modulate the formation of metabolite assemblies/doi:10.3390%2Fijms22179172/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9172, p 9172 (2021)

The formation of amyloid-like structures by metabolites is associated with several inborn errors of metabolism (IEMs). These structures display most of the biological, chemical and physical properties of protein amyloids. However, the molecular inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c099576fc9270ee6f18be44d7e283b
http://europepmc.org/articles/PMC8431448

Homocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide

Autor: Thanh D. Do, Santu Bera, Myra Gartner, Topaz Kreiser, Davide Levy, Ehud Gazit, Shira Shaham-Niv, Dan Frenkel, Dor Zaguri, Damilola S. Oluwatoba, Dana Laor Bar-Yosef, Hanaa Adsi, Dorin Sade Yazdi, Shahaf Sigal

Publikováno v: Proc Natl Acad Sci U S A

High levels of homocysteine are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Yet, the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56259ce07e6a5861cfb764d3d2d7af8
https://doi.org/10.1073/pnas.2017575118